Cleveland Clinic logo
Search

Crotalidae Immune Fab Injection

What is this medication?

CROTALIDAE IMMUNE FAB (kroe TAL i dee i MUNE fab) treats the symptoms of snakebites from pit vipers (crotalid) including rattlesnakes, copperheads, and cottonmouths (water moccasins). It works by binding to the snake’s venom in your body. This stops tissue injury and prevents worsening symptoms. It does not reverse effects that have already occurred.

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): CroFab

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Bleeding disorder or blood disease
  • An unusual or allergic reaction to crotalidae polyvalent immune fab, papaya, papain, latex, dust mites, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breastfeeding

How should I use this medication?

This medication is injected into a vein. It is given by your care team in a hospital or clinic setting.

Talk to your care team about the use of this medication in children. While it may be given to children for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply. This medication is not for regular use.

What may interact with this medication?

Interactions are not expected.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

Advertisement

What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medication.

This medication may increase your risk to bruise or bleed. Call your care team if you notice any unusual bleeding.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Unusual bruising or bleeding

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Fever, rash, itching, joint pain
  • Nausea

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This medication is given in a hospital or clinic. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Advertisement

Copyright ©2026 Elsevier Inc. All Rights Reserved.

Terms of use.

Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

Ad