Sirolimus is a medication that decreases your immune system’s response to a transplanted organ to prevent rejection. It can also treat lymphangioleiomyomatosis. This condition causes damage to your lung tissue that results in an inability of fully oxygenate blood, fluid in your lungs or a collapsed lung.
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SIROLIMUS (sir OH li mus) prevents the body from rejecting an organ transplant. It works by lowering the body's immune system response. This helps the body accept the donor organ. It is also used to treat lymphangioleiomyomatosis (LAM), a condition that affects the lungs, kidneys, and lymph nodes. It belongs to a group of medications called immunosuppressants.
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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
COMMON BRAND NAME(S): Rapamune
They need to know if you have any of these conditions:
Take this medication by mouth with water. Take it as directed on the prescription label at the same time every day. Do not cut, crush, or chew this medication. Swallow the tablets whole. You can take it with or without food. You should always take it the same way. Keep taking it unless your care team tells you to stop.
Do not take this medication with grapefruit juice.
If you are also taking cyclosporine, take this medication at least 4 hours after taking your cyclosporine dose.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as 13 years for selected conditions, precautions do apply.
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Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
If you miss a dose, take it as soon as you can, and call your care team. Call your care team if you vomit after a dose.
Do not take this medication with any of the following:
This medication may also interact with the following:
Other medications may affect the way this medication works. Talk with your care team about all of the medications you take. They may suggest changes to your treatment plan to lower the risk of side effects and to make sure your medications work as intended.
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
Visit your care team for regular checks on your progress. You may need blood work while you are taking this medication.
This medication can increase bad cholesterol and fats (such as LDL, triglycerides) and decrease good cholesterol (HDL) in your blood. You may need blood tests to check your cholesterol. Ask your care team what you can do to lower your risk of high cholesterol while taking this medication.
This medication may increase your risk of getting an infection. Call your care team for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick.
This medication may increase blood sugar. The risk may be higher in patients who already have diabetes. Ask your care team what you can do to lower your risk of diabetes while taking this medication.
Talk to your care team about your risk of cancer. You may be more at risk for certain types of cancer if you take this medication.
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Talk to your care team if you wish to become pregnant or think you might be pregnant. This medication can cause serious birth defects if taken during pregnancy and for 12 weeks after the last dose. A reliable form of contraception is recommended while taking this medication and for 12 weeks after the last dose. Talk to your care team about reliable forms of contraception.
Talk to your care team before breastfeeding. Changes to your treatment plan may be needed.
This medication may cause infertility. Talk to your care team if you are concerned about your fertility.
Side effects that you should report to your care team as soon as possible:
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Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.