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Lomitapide Capsules

Lomitapide lowers your blood cholesterol level caused by certain genetic conditions. Cholesterol is a waxy substance that your body needs to function. This medication comes in a capsule form that you can take with water as directed. Take it on an empty stomach and don’t take it with grapefruit juice.

What is this medication?

LOMITAPIDE (loe MI ta pide) treats high cholesterol. It works by reducing the amount of cholesterol made by your body. Changes to diet and exercise are often combined with this medication.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Juxtapid

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Frequently drink alcohol
  • Intestine problems
  • Kidney disease
  • Liver disease
  • Pancreatic disease
  • An unusual or allergic reaction to lomitapide, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

Take this medication by mouth with water. Take it as directed on the prescription label at the same time every day. Do not cut, crush, or chew this medication. Swallow the capsules whole. Take it on an empty stomach, at least 2 hours after food. Keep taking it unless your care team tells you to stop.

Take this medication at least 4 hours before or at least 4 hours after administration of a bile acid sequestrant.

Do not take this medication with grapefruit juice.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

It is important not to miss any doses. Talk to your care team about what to do if you miss a dose.

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What may interact with this medication?

Do not take this medication with any of the following:

  • Adagrasib
  • Aprepitant, fosaprepitant
  • Berotralstat
  • Boceprevir
  • Calcium channel blockers, such as diltiazem or verapamil
  • Certain antibiotics, such as ciprofloxacin, clarithromycin, erythromycin, telithromycin
  • Certain antiviral medications for HIV or AIDS
  • Certain medications for fungal infections, such as fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole
  • Conivaptan
  • Crizotinib
  • Grapefruit juice
  • Imatinib
  • Nefazodone

This medication may also interact with the following:

  • Acetaminophen
  • Ambrisentan
  • Bicalutamide
  • Certain medications for blood pressure, heart disease, irregular heartbeat
  • Certain medications for cholesterol, such as atorvastatin, lovastatin, simvastatin, cholestyramine, colestipol
  • Certain medications for depression, anxiety, or mental health conditions
  • Certain medications for diabetes, such as saxagliptin or sitagliptin
  • Certain medications for stomach problems, such as cimetidine or ranitidine
  • Certain medications that treat or prevent blood clots, such as warfarin, dabigatran, ticagrelor
  • Cilostazol
  • Colchicine
  • Cyclosporine
  • Estrogen and progestin hormones
  • Everolimus
  • Fexofenadine
  • Isoniazid
  • Isotretinoin
  • Lapatinib
  • Methotrexate
  • Nilotinib
  • Pazopanib
  • Sirolimus
  • Supplements, such as ginkgo biloba and goldenseal
  • Tamoxifen
  • Tetracycline
  • Topotecan
  • Zileuton

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.

Drinking alcohol with this medication can increase the risk of side effects.

Talk to your care team if you wish to become pregnant or think you might be pregnant. This medication can cause serious birth defects if taken during pregnancy. Estrogen and/or progestin hormones may not work as well while you are taking this medication. A barrier contraceptive, such as a condom or diaphragm, is recommended. Talk to your care team about other forms of contraception.

Talk to your care team before breastfeeding. Changes to your treatment plan may be needed.

Taking this medication is only part of a total heart healthy program. Ask your care team if there are other changes you can make to improve your overall health.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

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  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Constipation
  • Diarrhea
  • Gas
  • Nausea
  • Stomach pain
  • Upset stomach
  • Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store between 15 and 30 degrees C (59 and 86 degrees F). Protect from moisture. Keep the container tightly closed. Get rid of any unused medication after the expiration date.

To get rid of medication that is no longer needed or has expired:

  • Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
  • If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

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NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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