What is this medicine?

GOSERELIN (GOE se rel in) is similar to a hormone found in the body. It lowers the amount of sex hormones that the body makes. Men will have lower testosterone levels and women will have lower estrogen levels while taking this medicine. In men, this medicine is used to treat prostate cancer; the injection is either given once per month or once every 12 weeks. A once per month injection (only) is used to treat women with endometriosis, dysfunctional uterine bleeding, or advanced breast cancer.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Zoladex

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • bone problems
  • diabetes
  • heart disease
  • history of irregular heartbeat
  • an unusual or allergic reaction to goserelin, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for injection under the skin. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • cisapride
  • dronedarone
  • pimozide
  • thioridazine

This medicine may also interact with the following medications:

  • other medicines that prolong the QT interval (an abnormal heart rhythm)

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care provider for regular checks on your progress. Your symptoms may appear to get worse during the first weeks of this therapy. Tell your doctor or healthcare provider if your symptoms do not start to get better or if they get worse after this time.

Your bones may get weaker if you take this medicine for a long time. If you smoke or frequently drink alcohol you may increase your risk of bone loss. A family history of osteoporosis, chronic use of drugs for seizures (convulsions), or corticosteroids can also increase your risk of bone loss. Talk to your doctor about how to keep your bones strong.

This medicine should stop regular monthly menstruation in women. Tell your doctor if you continue to menstruate.

Women should not become pregnant while taking this medicine or for 12 weeks after stopping this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

Men should inform their doctors if they wish to father a child. This medicine may lower sperm counts. Talk to your health care professional or pharmacist for more information.

This medicine may increase blood sugar. Ask your healthcare provider if changes in diet or medicines are needed if you have diabetes.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • bone pain
  • breathing problems
  • changes in vision
  • chest pain
  • feeling faint or lightheaded, falls
  • fever, chills
  • pain, swelling, warmth in the leg
  • pain, tingling, numbness in the hands or feet
  • signs and symptoms of high blood sugar such as being more thirsty or hungry or having to urinate more than normal. You may also feel very tired or have blurry vision
  • signs and symptoms of low blood pressure like dizziness; feeling faint or lightheaded, falls; unusually weak or tired
  • stomach pain
  • swelling of the ankles, feet, hands
  • trouble passing urine or change in the amount of urine
  • unusually high or low blood pressure
  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • change in sex drive or performance
  • changes in breast size in both males and females
  • changes in emotions or moods
  • headache
  • hot flashes
  • irritation at site where injected
  • loss of appetite
  • skin problems like acne, dry skin
  • vaginal dryness

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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