Medroxyprogesterone injection [Malignancy]

What is this medication?

MEDROXYPROGESTERONE (me DROX ee proe JES te rone) is a man-made hormone. It is used to treat the symptoms of endometrial and renal cancer.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Depo-Provera

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

•blood vessel disease

•breast cancer

•history of a blood clot in the lungs or legs

•liver disease

•mental depression

•migraine

•seizures

•stroke

•vaginal bleeding

•an unusual or allergic reaction to medroxyprogesterone, other hormones, medicines, foods, dyes, or preservatives

•pregnant or trying to get pregnant

•breast-feeding

How should I use this medication?

This medicine is for injection into a muscle. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.

What may interact with this medication?

Do not take this medicine with any of the following medications:

•bosentan

This medicine may also interact with the following medications:

•aminoglutethimide

•antibiotics or medicines for infections, especially rifampin, rifabutin, rifapentine, and griseofulvin

•aprepitant

•barbiturate medicines such as phenobarbital or primidone

•bexarotene

•carbamazepine

•medicines for seizures like ethotoin, felbamate, oxcarbazepine, phenytoin, topiramate

•modafinil

•St. John's wort

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medicine.

Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

•allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

•breast tenderness or discharge

•breathing problems

•changes in vision

•depression

•feeling faint or lightheaded, falls

•fever

•pain in the abdomen, chest, groin, or leg

•problems with balance, talking, walking

•unusually weak or tired

•yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

•fluid retention, swelling

•headache

•irregular periods, spotting, or absent periods

•irritation at site where injected

•nausea

•trouble sleeping

•weight gain or loss

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This drug is given in a hospital or clinic and will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.