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Capsaicin Cream, Lotion, or Solution

Capsaicin is a medicated pain reliever cream, lotion or solution. It treats muscle and joint pain. You can apply this cream as directed on your skin near your muscle or joint that causes you pain.

What is this medication?

CAPSAICIN (cap SAY sin) relieves minor pain in your muscles and joints. It works by making your skin feel warm or cool, which blocks pain signals going to the brain.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Arthricare for Women, Arthritis Pain Relieving, Capzasin-HP, Capzasin-P, Castiva Warming, Circatrix, DermacinRx, DermacinRx Circata, DermacinRx Penetral, DiabetAid, Zostrix, Zostrix HP, Zostrix Neuropathy

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Large areas of burned or damaged skin
  • Skin conditions or disease
  • An unusual or allergic reaction to capsaicin, hot peppers, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

This medication is for external use only. Do not take by mouth. Wash your hands before and after use. If you are treating your hands, only wash your hands before use. Do not get it in your eyes. If you do, rinse your eyes with plenty of cool tap water. Use it as directed on the label at the same time every day. Do not use it more than directed.

Apply a thin film of the medication to the affected area. Do not apply to burned or damaged skin. Do not cover the area with a bandage.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

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NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you take this medication on a regular basis, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

Interactions are not expected. Do not use any other skin products on the affected area without talking to your care team.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.

This product is sensitive to body heat changes. If your skin gets too hot, more medication may go into the skin. Do not take hot baths. Do not sunbathe. Do not use hot tubs, saunas, hairdryers, heating pads, electric blankets, heated waterbeds, or tanning lamps. Do not do exercise that increases your body temperature.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Mild skin irritation, redness, or dryness

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature, between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any unused medication after the expiration date.

Some products are flammable. Avoid exposure to heat, fire, flame, and smoking.

To get rid of medications that are no longer needed or have expired:

  • Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
  • If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

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NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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