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Methyldopa Tablets

Methyldopa is a medication that treats high blood pressure. Blood pressure is the measurement of the force of blood pushing against blood vessel walls. High blood pressure can put you at risk for stroke, heart failure, kidney failure and other medical problems.

What is this medication?

METHYLDOPA (meth ill DOE pa) treats high blood pressure. It works by relaxing blood vessels, which decreases the amount of work the heart has to do.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Aldomet

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Anemia
  • Kidney or liver disease
  • An unusual or allergic reaction to methyldopa, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

Take this medication by mouth. Take it as directed on the prescription label at the same time every day. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

Do not take this medication with any of the following:

  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate

This medication also may interact with the following:

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  • Iron salts
  • Lithium
  • Medications for high blood pressure

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Check your heart rate and blood pressure regularly. Ask your care team what your heart rate should be and when you should contact them. If you get a fever, especially in the first few months, call your care team. Do not treat yourself.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. To avoid dizzy or fainting spells, do not stand or sit up quickly, especially if you are an older person. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your care team if the problem does not go away or is severe.

Iron can stop the absorption of this medication. Do not take this medication with iron preparations or multiple vitamins containing iron. If you have to take iron, make sure that there are at least 2 hours between iron and methyldopa doses.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Heart failure—shortness of breath, swelling of the ankles, feet, or hands, sudden weight gain, unusual weakness or fatigue
  • Hemolytic anemia—unusual weakness or fatigue, dizziness, headache, trouble breathing, dark urine, yellowing skin or eyes
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Unusual bruising or bleeding

Side effects that usually do not require medical attention report to your care team if they continue or are bothersome:

  • Diarrhea
  • Drowsiness
  • Dry mouth
  • Headache

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from light. Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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