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Gemfibrozil Tablets

What is this medication?

GEMFIBROZIL (jem FI broe zil) treats high cholesterol and triglyceride levels in your blood. It works by decreasing bad cholesterol and fats (such as LDL, triglycerides) and increasing good cholesterol (HDL) in your blood. It belongs to a group of medications called fibrates. Changes to diet and exercise are often combined with this medication.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Lopid

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Cataracts
  • Gallbladder disease
  • Heart disease
  • History of pancreatitis
  • Kidney disease
  • Liver disease
  • An unusual or allergic reaction to gemfibrozil, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

Take this medication by mouth. Take it as directed on the prescription label at the same time every day. Take it on an empty stomach, at least 30 minutes before food. Keep taking it unless your care team tells you to stop.

Take this medication at least 2 hours BEFORE or at least 4 hours AFTER administration of a bile acid sequestrant.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

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What may interact with this medication?

Do not take this medication with any of the following:

  • Dasabuvir
  • Elagolix
  • Elbasvir; grazoprevir
  • Repaglinide
  • Selexipag
  • Simvastatin

This medication may also interact with the following:

  • Bosentan
  • Certain medications that treat or prevent blood clots, such as warfarin
  • Certain medications for cholesterol, such as atorvastatin, colestipol, ezetimibe, fluvastatin, pitavastatin, pravastatin
  • Colchicine
  • Dabrafenib
  • Enzalutamide
  • Glyburide
  • Loperamide
  • Montelukast
  • Olmesartan
  • Paclitaxel
  • Pioglitazone
  • Red Yeast Rice
  • Rifampin
  • Rosiglitazone
  • Valsartan

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.

This medication can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and sunscreen. Do not use sun lamps or tanning beds/booths.

This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.

Taking this medication is only part of a total heart healthy program. Ask your care team if there are other changes you can make to improve your overall health.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Gallbladder problems—severe stomach pain, nausea, vomiting, fever
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing
  • Muscle injury—unusual weakness or fatigue, muscle pain, dark yellow or brown urine, decrease in amount of urine
  • Pancreatitis—severe stomach pain that spreads to your back or gets worse after eating or when touched, fever, nausea, vomiting
  • Unusual bruising or bleeding

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Blurry vision
  • Change in sex drive or performance
  • Headache
  • Stomach pain
  • Upset stomach

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from light and moisture. Keep the container tightly closed. Get rid of any unused medication after the expiration date.

To get rid of medication that is no longer needed or has expired:

  • Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
  • If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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