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Staphylococcal Scalded Skin Syndrome

Medically Reviewed.Last updated on 01/12/2026.

Scalded skin syndrome happens when bacterial toxins attack your skin. The damaged skin layer separates and sheds away, exposing raw, reddened skin beneath. It’s a severe condition that needs immediate care. It’s more common in children, and their outlook is usually excellent. While rare in adults, it’s also usually more dangerous for them.

What Is Scalded Skin Syndrome?

Scalded skin syndrome is a skin disease that happens when bacteria damage areas of your child’s skin. Skin from those areas sheds and falls off, leaving shiny areas that look like burns. It’s most common in children, especially those under 6 years old.

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The full name of the condition is staphylococcal scalded skin syndrome, or just staph scalded skin syndrome. That’s because Staphylococcus-type bacteria cause it. In children, it’s also known as Ritter disease, and sometimes SSSS for short.

IMPORTANT: Scalded skin syndrome can lead to dangerous or even life-threatening complications without treatment. And it has similar symptoms to several dangerous conditions. Having the skin symptoms means you need to go to a hospital or emergency room right away.

Symptoms and Causes

Symptoms of scalded skin syndrome

Scalded skin syndrome can cause several skin symptoms. But before the skin symptoms start, most people develop vague symptoms. Those often look like an upper respiratory infection and can include:

  • Fatigue
  • Fever
  • Inflammation in your nose (rhinitis), ears (otitis media) and eyes (conjunctivitis)
  • Irritability
  • Malaise (a general unwell feeling)
  • Muscle and joint aches
  • Sore throat
  • Vomiting

About 24 hours after those early symptoms, the skin symptoms start. They include:

  • A rash that’s large, painful and spread out across your child’s body
  • Blistering (these are flaccid, meaning they look deflated and hang downward)
  • Peeling or flaky areas where the skin will shed if pressed lightly
  • Raw, moist patches of skin left behind when upper layers of skin come off

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The skin symptoms can affect the whole body in newborns. In infants and preschool- or school-age children, the symptoms usually only affect their upper bodies.

The most common places for the rash to show are your child’s:

  • Face
  • Neck
  • Armpits
  • Shoulders
  • Groin

It doesn’t affect the palms of your hands, soles of your feet, or mucous membranes like those inside your mouth or nose.

Scalded skin syndrome causes

Scalded skin syndrome happens because of Staphylococcus bacteria like Staphylococcus aureus. This can happen in two ways:

  • Infection: When bacteria enter your body through a wound
  • Colonization: From bacteria that ordinarily live on or in your body without making you sick

But staph bacteria don’t cause it directly. Instead, it’s from toxins the bacteria make. The toxins are harmful substances that can cause these skin changes.

About 1 in 20 of the known S. aureus strains make toxins called exfoliatins. These toxins get into your bloodstream and spread throughout your body. Once exfoliatins get to your skin, they attack proteins that help skin cells stick together. Without those proteins, your epidermis (the outermost layer) and dermis (the layer right beneath) pull apart. That’s why the epidermis can shed or peel off.

Risk factors

There are a few main risk factors that contribute to having scalded skin syndrome. They include:

  • Being under 6 years old: This is the main risk factor and why most cases of scalded skin syndrome happen in very young children.
  • A compromised immune system: Having a weakened immune system can keep your body from fighting off bacteria that cause scalded skin syndrome.
  • Weakened or damaged kidneys: Your kidneys can filter out the toxins that cause scalded skin syndrome. But weakened or damaged kidneys might not be able to filter toxins out fast enough.

Experts suspect that children under 6 have a higher risk because of the other two factors. Young children don’t have strong immune systems. And their kidneys might not be mature enough to filter toxins effectively.

Other risk factors include having:

  • Sepsis
  • Diabetes
  • Alcohol use disorder or substance use disorder
  • Cancer
How to lower your risk

Handwashing may lower the odds of scalded skin syndrome in some cases.

Other things that may lower your risk include:

  • Avoiding physical contact with someone who has the infection
  • Cleaning and sanitizing frequently touched surfaces and objects, like toys
  • Avoiding sharing personal products like towels with others if you or they have an infection

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Complications of scalded skin syndrome

Scalded skin syndrome has a few major complications. They include:

  • Dehydration and electrolyte imbalances (especially when you lose more skin)
  • Difficulty regulating body temperature (especially when you lose more skin)
  • Secondary infections
  • Sepsis

Diagnosis and Tests

How doctors diagnose scalded skin syndrome

Healthcare providers can diagnose scalded skin syndrome using a combination of tools. They include:

  • Blood tests (either for signs of the bacteria or toxins)
  • Swab (culture) tests on your child’s skin or mucus in their nose or throat
  • Urinalysis to check electrolyte levels
  • Skin biopsy (usually a sample of shedding skin taken without causing pain)

Management and Treatment

Scalded skin syndrome prevention in children revolves around stopping germs from spreading and preventing infections
Preventing scalded skin syndrome in children under 6 can involve many methods, including distancing, cleaning and handwashing.

How is scalding skin syndrome treated?

Antibiotics are the main treatment for scalded skin syndrome. These mainly come through an intravenous (IV) line, usually in your child’s hand or arm.

The other treatments for scalded skin syndrome are mostly supportive. That means they help with other symptoms or effects of this condition. They include:

  • IV fluids (to prevent dehydration)
  • Oral or IV medicines like acetaminophen for pain and fever
  • Pressure-relieving mattresses (to ease pain and reduce skin loss)
  • Topical treatments like petroleum jelly (they ease symptoms and may prevent secondary infections)
  • Other types of wound care, like bandages or dressings
  • Plasma exchange, which helps remove toxins from circulation (not common)

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It’s common for children with scalded skin syndrome not to want to be touched or held. That’s because of discomfort or pain from the condition. And that’s why many treatments focus on minimizing and managing skin effects or symptoms.

Recovery time

Scalded skin syndrome heals quickly, especially in children. It usually heals within five to seven days, but can take up to three weeks.

Outlook / Prognosis

What can I expect if I have this condition?

Scalded skin syndrome in children often looks severe. And while it can be dangerous and needs immediate care, the overall outlook (prognosis) is good. Most children will make a full recovery without any scarring.

The outlook for scalded skin syndrome in adults isn’t as favorable. That’s usually because of the risk factors and underlying conditions that can contribute when adults have it.

Additional Common Questions

What is the survival rate of staphylococcal scalded skin syndrome?

The survival rate for scalded skin syndrome in children is very high. Even in very severe cases, the survival rate is between 89% and 96%.

In adults, scalded skin syndrome has a survival rate of about 2 out of 5. Typically, it only happens in adults with underlying conditions that make it more severe.

A note from Cleveland Clinic

It started as a fever and what looked like a cold, or something similar. Now, your child has a rash and doesn’t want to be touched or held. Scalded skin syndrome can be a scary-looking condition, and it does need immediate medical care. Fortunately, the outlook for this condition is excellent when children get that care quickly. Most children fully recover and won’t even have a scar left behind.

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If you have questions about whether your child might be showing symptoms, talk to their pediatrician. They can advise you on how to proceed. And when in doubt, you know your child best. There’s nothing wrong with acting out of caution to make sure they’re OK.

Experts You Can Trust

Medically Reviewed.Last updated on 01/12/2026.

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References

Cleveland Clinic's health articles are based on evidence-backed information and review by medical professionals to ensure accuracy, reliability, and up-to-date clinical standards.

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