Skeeter syndrome is large, itchy, swollen welts you get after a mosquito bite. It’s more than just a small bump. It’s caused by an inflammatory reaction to proteins in mosquito saliva. Treatments include anti-itch creams, antihistamines and, sometimes, oral corticosteroids or a steroid shot.
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Skeeter syndrome is a large, local inflammatory reaction to mosquito bites. It causes redness, warmth, swelling and/or itching where a mosquito bit you. The area is sometimes hard and painful.
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Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy
Skeeter syndrome is more than just the small, annoying bumps many people get from mosquito bites. It can sometimes make you wonder if you have a skin infection. It’s most common in young kids.
Rarely, it can cause fever, hives in many areas of your body or swollen lymph nodes.
The main symptom of skeeter syndrome is large areas of swelling where a mosquito bit you. You might notice:
Rarely, you might get a fever, hives in many areas of your body or swollen lymph nodes. Anaphylaxis, a type of severe allergic reaction that can affect your whole body, has been reported very rarely. Call 911 (or your local emergency services number) or go to the emergency room immediately if you experience weakness, dizziness or difficulty breathing.
Skeeter syndrome happens when your body overreacts to proteins in mosquito saliva (spit). When a mosquito bites you, it injects you with its saliva. If your immune system reacts to proteins in the saliva, you can get large areas of swelling and itching. Symptoms usually start eight to 10 hours after the bite and get better within three to 10 days.
Different types of mosquitoes have different proteins in their saliva. You may react to some types of mosquitoes and not others.
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Large, swollen areas can sometimes break the skin and become ulcers — especially if you scratch at them. They can become infected with bacteria or leave a scar.
A healthcare provider can diagnose skeeter syndrome by looking at the reaction. They’ll ask you about when you were bitten and when the reaction started. They might also ask whether you’ve traveled recently (other regions may have different mosquitoes or biting insects). Be sure to let them know if you’ve had other symptoms, like a fever or difficulty breathing.
There’s no specific type of test (like an allergy test) to diagnose skeeter syndrome.
A provider might recommend these treatments:
If you have severe symptoms, you may need oral corticosteroids or a shot of corticosteroids.
See a healthcare provider if you have large areas of swelling after a mosquito bite. Call 911 (or your local emergency services number) or go to the emergency room if you experience:
Symptoms of skeeter syndrome can last three to 10 days. Many people can manage at home with over-the-counter treatments. Contact a healthcare provider if symptoms are bothersome or keep you from your daily activities.
Kids are more likely to have large reactions to mosquito bites. This is because their immune systems haven’t yet been desensitized to proteins in mosquito saliva. Sometimes, the reaction can become less severe over time. But adults can also have skeeter syndrome.
The best way to prevent skeeter syndrome is to avoid mosquito bites. Here are some tips:
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Mosquito bites are annoying for most people. But for some, they can cause large, painful skin reactions. If skeeter syndrome is disrupting your life, talk to a healthcare provider. They can give you suggestions to find relief. Get help right away if you’re having severe symptoms.
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Cleveland Clinic’s health articles are based on evidence-backed information and review by medical professionals to ensure accuracy, reliability and up-to-date clinical standards.
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