IRB Study Number 16-1460
Status Recruiting
Location Cleveland Clinic Main Campus
Institute Digestive Disease & Surgery Institute
Description
The overarching goal of this study is to optimize bariatric surgery weight loss outcomes through identification of key mechanisms that can be targeted for education and intervention.
Inclusion Criteria
- Male or Female between the ages of 18-65 years, inclusive
- In evaluation for RYGB or SG as primary procedure
- Planning to be available for two years of follow-up after surgery
Exclusion Criteria
- Alcohol or substance use disorder in the past year
- Severe psychiatric disorder that may affect the ability of the participant’s ability to comply with the protocol
- Tobacco use in the prior year
- Current medication known to significantly influence gastrointestinal transit time (e.g., opioids, anticholinergics, metoclopramide)
- Use of any oral or injectable antibiotic in the past month
- Use of prebiotic or probiotic in the past month
- History of significant intestinal disease or disorder that would influence the microbiome (e.g., Crohn’s Disease, etc.)
- History of significant gastrointestinal surgery that would influence the microbiome, not including cholecystectomy or appendectomy
- Inability to engage in physical activity or dietary monitoring
