IRB Study Number 24-514
Status Recruiting
Institute Taussig Cancer Institute
Description
Primary Objectives
1) demonstrate clinical feasibility of combining MRF with state-of-the-art parallel imaging techniques to achieve high-resolution quantitative imaging within a reasonable scan time of 5 min for whole brain coverage.
2) apply the developed quantitative approach in combination with IVIM MRI for differentiation of tumor recurrence and radiation necrosis.
Inclusion Criteria
4.1.1. Healthy subjects must meet all the following inclusion criteria to be eligible for enrollment:
Ages 21 - 60
No history of cerebrovascular disease
No cognitive impairments
Able to provide informed consent
4.1.2. Subjects with brain tumors must meet all the following inclusion criteria to be eligible for enrollment:
- Biopsy proven cases of developed recurrent tumor or radiation necrosis OR
a. PET identified with developed recurrent tumor or radiation necrosis OR
b. Highly suspicious case with developed recurrent tumor or radiation necrosis confirmed by tumor board, attending physician or surgeon
Age: 21 years and over
ECOG performance status 0-2
Life expectancy > 6 months.
Patient with other sites of extracranial metastatic disease or any prior or current systemic therapies will be considered and evaluated by the investigators of the study on a subject basis.
Exclusion Criteria
Pregnant women OR lactating women
Patients with ferromagnetic or otherwise non-MRI compatible aneurysm clips.
Patients who cannot go into the MRI scanner due to metal implants or other medical conditions.
The presence of an implanted medical device that is not MRI-compatible, including, but not limited to: pacemaker, defibrillator
Patients with contraindications for MRI due to embedded foreign metallic objects such as bullets, shrapnel, metalwork fragments, or other metallic material.
Known history of severe claustrophobia.
Patients under the age of 21
Patients unable to lay still in the scanner for 30 minutes at a time.
