IRB Study Number 22-1208
Status Recruiting
Institute Taussig Cancer Institute
Description
Primary Objective
To describe the pattern of electrical activity (neuronal hyperexcitability) in brain surrounding the enhancing tumor during open surgery in patients with high grade gliomas and its correlation with progression
Exploratory Objective
To determine the effect of electrical activity (neuronal hyperexcitability) in brain surrounding the enhancing tumor on the peritumoral immune microenvironment
Inclusion Criteria
Patients who have the appearance of high-grade glioma (HGG, WHO Grade 3 and 4, including GBM) on MR imaging are allowed to consent and will undergo the procedure if the frozen is consistent with HGG OR
Patients with a history of histologically-confirmed diagnosis of high grade glioma that are undergoing resection of a recurrent/progressive tumor that is likely recurrent/progressive high grade glioma as identified on preoperative MR imaging
Age ≥ 18 years old
Volumetric MRI within 1 month prior to surgery
Karnofsky performance status of 60 or higher
The participant (or legally acceptable representative if applicable) provides written informed consent for the trial.
Patients must be considered appropriate neurosurgical candidates with the following screening/baseline laboratory values within 1 month prior to surgery: (See protocol)
Exclusion Criteria
Severe co-morbidity that would confer excess risk of surgery as determined by the treating physician.
Any other major medical illnesses or psychiatric impairments that in the investigator's opinion will prevent administration or completion of protocol therapy.
Is pregnant
Coagulopathy or platelet dysfunction that increases the risk of intra and postoperative hemorrhage
Tumor location requiring DE placement/biopsy in eloquent or critical region of the brain (e.g. primary motor and sensory cortices, speech and vision centers, thalamus, basal ganglia, cerebellum, brain stem) as deemed by the neurosurgeon designing the surgical plan
