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Umesh N. Khot, MD


Umesh N. Khot, MD
Department: Cardiovascular Medicine
Location: Cleveland Clinic Main Campus
Mail Code J2-4
9500 Euclid Avenue
Cleveland, OH 44195
Umesh N. Khot, MD
Department: Heart and Vascular Institute
Vice Chair
Location: Cleveland Clinic Main Campus
Mail Code J2-4
9500 Euclid Avenue
Cleveland, OH 44195
Type of Doctor:
Adults Only

Biographical Sketch

Umesh N. Khot, MD, is a Vice Chairman of the Robert and Suzanne Tomsich Department of Cardiovascular Medicine and a staff cardiologist in the Section of Clinical Cardiology in the Sydell and Arnold Miller Family Heart & Vascular Institute, . His clinical specialties include coronary artery disease, heart attack care, heart valve disease and heart failure. He is board-certified in cardiovascular medicine, echocardiography and nuclear cardiology.

A graduate of The Ohio State University College of Medicine, Dr. Khot completed a residency in internal medicine at Stanford University Medical Center followed by a fellowship in cardiovascular medicine at Cleveland Clinic. He was appointed to the medical staff in 2011.

Prior to his appointment to the Cleveland Clinic staff, Dr. Khot was director of the Noninvasive Vascular Laboratory with Indiana Heart Physicians and director of the EHART® STEMI Program at St. Francis Heart Center in Indianapolis. He also was a member of the Practice Executive Committee and a member of the St. Francis Heart Center Cardiac Operations Group.

EHART® is a specialized triage and treatment protocol developed by Dr. Khot to reduce the time-to-treatment for heart attack patients who come to the emergency room. This protocol has led not only to improved time-to-treatment but also to an increased rate of survival after the heart attack. The American Heart Association and the American College of Cardiology have recognized this protocol as a major advance in heart attack care.

Dr. Khot is the author of a number of research articles in leading medical journals, including The New England Journal of Medicine, Journal of the American Medical Association (JAMA), Journal of the American College of Cardiology and Circulation. He has contributed to novel understanding of the role of vasodilator therapy in severe aortic stenosis, the association between risk factors and heart disease, and insights into outcomes in patients with heart failure and heart surgery.  His research has been cited within the practice guidelines of the American College of Cardiology, American Heart Association, and European Society of Cardiology. 

Dr. Khot has been a reviewer for JAMA, Circulation, American Heart Journal, Nature Practice Cardiovascular Medicine and American Journal of Cardiology.   He is a Fellow of the American College of Cardiology. 

 Dr. Khot enjoys spending time with his three children, traveling, and exploring the outdoors

Education & Fellowships

Fellowship - Cleveland Clinic
Cardiovascular Medicine
Cleveland, OH USA
Residency - Stanford University
Internal Medicine
Stanford, CA USA
Medical School - The Ohio State University College of Medicine and Public Health
Columbus, OH USA
Undergraduate - Northwestern University
Evanston, IL USA


  • Internal Medicine- Cardiovascular Disease
  • Certification Board of Nuclear Cardiology- Adult Comprehensive Echocardiography
  • Certification Board of Nuclear Cardiology- Nuclear Cardiology

Specialty Interests

General cardiology, heart disease, nuclear imaging - heart, clinical cardiology, heart attack, heart valve disease, echocardiogram, cardiac catheterization

Awards & Honors

  • Patient Safety Hero Award, Indianapolis Coalition for Patient Safety (2007)
  • Tony and Mary Hulman Health Achievement Award, Indiana Public Health Foundation (2007)
  • Cleveland Clinic Tarazi Award for Cardiovascular Research (2002)


  • American College of Cardiology

Treatment & Services

  • Abnormal Stress Test
  • Adult General Clinical Cardiology
  • Cardiovascular Medicine Department
  • Clinical Cardiology Section
  • Diagnostic Clinical Cardiology
  • General Cardiology

Specialty in Diseases and Conditions

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 5/6/2016, Dr. Khot has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Royalty Payments. Dr. Khot receives or has the right to receive royalty payments for inventions or discoveries commercialized through the companies shown below:

  • Cardiac Protection Solutions, LLC
  • St. Francis Hospital and Health Centers

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers’ discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Languages Spoken

  • English

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