Pediatric Infectious Diseases

Antimicrobial Stewardship

2023

Guideline-Consistent Antibiotic Selection by Diagnosis

2019-2023

The Centers for Disease Control and Prevention (CDC) estimates that out of nearly 154 million outpatient antibiotic prescriptions issued each year, approximately 30% are unnecessary. To that end, the Cleveland Clinic Antimicrobial Stewardship committee, in collaboration with the Office Clinical Compliance, has begun tracking the appropriateness of prescriptions for 5 common diagnoses: otitis media, pharyngitis, sinusitis, urinary tract infection and upper respiratory tract infections. The committee evaluates whether diagnostic codes and prescriptions were consistent with clinical practice guidelines, and whether prescriptions were consistent with patient allergy to penicillin, if applicable. The committee does not consider micro-biologic data, additional antibiotic allergies, previous treatment failures, or other patient-specific factors.

Otitis MediaPharyngitisSinusitisUrinary Tract Infection (UTI)Upper Respiratory Tract Infection (URTI)
2019 Cleveland Clinic Children's

85%

(6491/7640)

83%

(2509/3014)

87%

(2119/2424)

84%

(173/206)

90%

(13987/15521)

2020 Cleveland Clinic Children's

86%

(2397/2789)

86%

(1123/1313)

89%

(748/840)

54%

(85/155)

92%

(6995/7575)

2021 Cleveland Clinic Children's

89%

(3149/3527)

84%

(366/435)

90%

(2413/2692)

68%

(118/174)

94%

(15520/16894)

2022 Cleveland Clinic Children's

87%

(6856/7893)

81%

(1173/1452)

90%

(2413/2692)

72%

(142/196)

92%

(15520/16894)

2023 Cleveland Clinic Children's

89%

(7710/8672)

85%

(4891/5754)

90%

(2746/3060)

73%

(166/227)

93%

(17069/18447)

National Estimate¹67%60%50%N/AN/A

¹Hersh AL, Fleming-Dutra KE, Shapiro DJ, Hyun DY, Hicks LA; for the Outpatient Antibiotic Use Target-Setting Workgroup. Frequency of first-line antibiotic selection among US ambulatory care visits for otitis media, sinusitis, and pharyngitis. _JAMA Intern Med. _2016;176(12):1870–1872

ᵃNo national estimate available.

ᵇDefinition change eliminated 3rd generation cephalosporin as guideline concordant (88% old-definition)