Spironolactone; Hydrochlorothiazide Tablets

Spironolactone hydrochlorothiazide is a medication that treats high blood pressure and fluid retention. It works by causing your kidneys to get rid of excess water and salt. You take it in a pill that you swallow with water.

What is this medication?

SPIRONOLACTONE; HYDROCHLOROTHIAZIDE (speer on oh LAK tone; hye droe klor oh THYE a zide) treats high blood pressure. It may also be used to reduce swelling related to heart, kidney, or liver disease. It helps your kidneys remove more fluid and salt from your blood through the urine. It is a combination of two diuretics.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Aldactazide

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What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Diabetes
  • Immune system problems, like lupus
  • Kidney disease
  • Liver disease
  • An unusual reaction to spironolactone, hydrochlorothiazide, sulfa medications, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

Take this medication by mouth. Take it as directed on the prescription label at the same time every day. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

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What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

Do not take this medication with any of the following:

  • Cidofovir
  • Eplerenone
  • Tranylcypromine

This medication may also interact with the following:

  • Aspirin
  • Certain medications for blood pressure, heart disease like benazepril, lisinopril, losartan, valsartan
  • Certain medications that treat or prevent blood clots like heparin and enoxaparin
  • Cholestyramine
  • Cyclosporine
  • Digoxin
  • Lithium
  • Medications that relax muscles for surgery
  • NSAIDs, medications for pain and inflammation, like ibuprofen or naproxen
  • Other diuretics
  • Potassium supplements
  • Steroid medications like prednisone or cortisone
  • Trimethoprim

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Check your blood pressure as directed. Ask your care team what your blood pressure should be, and when you should contact them.

This medication may increase blood sugar. Ask your care team if changes in diet or medications are needed if you have diabetes.

You must not get dehydrated. Ask your care team how much fluid you need to drink a day. Check with them if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take this medication.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medication. Avoid alcoholic drinks.

Talk to your care team about your risk of skin cancer. You may be more at risk for skin cancer if you take this medication.

This medication can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Dehydration—increased thirst, dry mouth, feeling faint or lightheaded, headache, dark yellow or brown urine
  • Gout—severe pain, redness, warmth, or swelling in joints, such as the big toe
  • High potassium level—muscle weakness, fast or irregular heartbeat
  • Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
  • Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision
  • Low potassium level—muscle pain or cramps, unusual weakness or fatigue, fast or irregular heartbeat, constipation
  • Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Breast pain or tenderness
  • Change in sex drive or performance
  • Drowsiness
  • Headache
  • Irregular menstrual cycles or spotting
  • Unexpected breast tissue growth
  • Upset stomach

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Copyright ©2024 Elsevier Inc. All Rights Reserved.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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