What is this medication?
LUBIPROSTONE (loo bi PROS tone) treats irritable bowel syndrome (IBS) with constipation. It may also treat chronic constipation. It works by softening the stool, making it easier to have a bowel movement.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
COMMON BRAND NAME(S): Amitiza
What should I tell my care team before I take this medication?
They need to know if you have any of these conditions:
- History of blockage in your bowels
- History of stool (fecal) impaction
- Liver disease
- Stomach cancer
- An unusual or allergic reaction to lubiprostone, other medications, foods, dyes, or preservatives
- Pregnant or trying to get pregnant
How should I use this medication?
Take this medication by mouth with water. Take it as directed on the prescription label at the same time every day. Do not cut, crush or chew this medication. Swallow the capsules whole. Take it with food. Keep taking it unless your care team tells you to stop.
Talk to your care team about the use of this medication in children. It is not approved for use in children.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
What may interact with this medication?
- Medications that treat diarrhea
- Other medications for constipation
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medication?
Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.
What side effects may I notice from receiving this medication?
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Bowel blockage—stomach cramping, unable to have a bowel movement or pass gas, loss of appetite, vomiting
- Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision
- Shortness of breath or trouble breathing
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
- Stomach pain
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medication?
Keep out of the reach of children and pets.
Store at 25 degrees C (77 degrees F). Protect from light. Avoid exposure to extreme heat/cold. Throw away any unused medication after the expiration date.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy