Fluorouracil, 5FU; Diclofenac topical cream

What is this medication?

FLUOROURACIL; DICLOFENAC (flure oh YOOR a sil; dye KLOE fen ak) is a combination of a topical chemotherapy agent and non-steroidal anti-inflammatory drug (NSAID). It is used on the skin to treat skin cancer and skin conditions that could become cancer.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): FLUORAC

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• bleeding problems
• cigarette smoker
• DPD enzyme deficiency
• heart disease
• high blood pressure
• if you frequently drink alcohol containing drinks
• kidney disease
• liver disease
• open or infected skin
• stomach problems
• swelling or open sores at the treatment site
• recent or planned coronary artery bypass graft (CABG) surgery
• an unusual or allergic reaction to fluorouracil, diclofenac, aspirin, other NSAIDs, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medication?

This medicine is only for use on the skin. Follow the directions on the prescription label. Wash hands before and after use. Wash affected area and gently pat dry. To apply this medicine use a cotton-tipped applicator, or use gloves if applying with fingertips. If applied with unprotected fingertips, it is very important to wash your hands well after you apply this medicine. Avoid applying to the eyes, nose, or mouth. Apply enough medicine to cover the affected area. You can cover the area with a light gauze dressing, but do not use tight or air-tight dressings. Finish the full course prescribed by your doctor or health care professional, even if you think your condition is better. Do not stop taking except on the advice of your doctor or health care professional.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, apply it as soon as you can. If it is almost time for your next dose, only use that dose. Do not apply extra doses. Contact your doctor or health care professional if you miss more than one dose.

What may interact with this medication?

Interactions are not expected. Do not use any other skin products without telling your doctor or health care professional.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your doctor or healthcare provider for checks on your progress. You will need to use this medicine for 2 to 6 weeks. This may be longer depending on the condition being treated. You may not see full healing for another 1 to 2 months after you stop using the medicine.

This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine. Contact your healthcare provider right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.

Treated areas of skin can look unsightly during and for several weeks after treatment with this medicine.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Serious side effects or death can occur if a pet comes into contact with this drug. Contact a vet right away if a pet touches or licks the drug on your skin or comes into contact with the container. Throw away or wash any items used to apply this drug. Wash your hands after applying the drug. Make sure the drug does not get on clothing, carpet, or furniture. If you cannot avoid skin to skin contact with your pet, ask your health care provider if you can cover the area(s) where you apply this drug.

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your healthcare provider or pharmacist for more information.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• black or bloody stools, blood in the urine or vomit
• blurred vision
• chest pain
• difficulty breathing or wheezing
• rash, fever, and swollen lymph nodes
• redness, blistering, peeling or loosening of the skin, including inside the mouth
• severe redness and swelling of normal skin
• slurred speech or weakness on one side of the body
• trouble passing urine or change in the amount of urine
• unexplained weight gain or swelling
• unusually weak or tired
• yellowing of eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• increased sensitivity of the skin to sun and ultraviolet light
• pain and burning of the affected area
• scaling or swelling of the affected area
• skin rash, itching of the affected area
• tenderness

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.