Locations:

Trandolapril Tablets

What is this medication?

TRANDOLAPRIL (tran DOLE a pril) treats high blood pressure and heart failure. It may also be used to prevent further damage after a heart attack. It works by relaxing blood vessels, which decreases the amount of work the heart has to do. It belongs to a group of medications called ACE inhibitors.

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Mavik

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Autoimmune conditions, such as lupus
  • Diet low in salt
  • Heart or blood vessel conditions
  • Kidney disease
  • Liver disease
  • Low blood pressure
  • Previous swelling of the tongue, face, or lips with trouble breathing, trouble swallowing, hoarseness, or tightening of the throat
  • An unusual or allergic reaction to trandolapril, other ACE inhibitors, insect venom, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breastfeeding

How should I use this medication?

Take this medication by mouth. Take it as directed on the prescription label at the same time every day. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Advertisement

What may interact with this medication?

Do not take this medication with any of the following:

  • Sacubitril; valsartan

This medication may also interact with the following:

  • Diuretics
  • Lithium
  • NSAIDs, medications for pain and inflammation, such as ibuprofen or naproxen
  • Other medications for high blood pressure
  • Potassium salts or supplements

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Check your blood pressure as directed. Know what your blood pressure should be and when to contact your care team.

Taking this medication is only part of a total heart healthy program. Ask your care team if there are other changes you can make to improve your overall health.

Check with your care team if you have severe diarrhea, nausea, and vomiting, or if you sweat a lot. The loss of too much body fluid may make it dangerous for you to take this medication.

This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.

Avoid salt substitutes unless you are told otherwise by your care team.

Do not treat yourself for coughs, colds, or pain while you are using this medication without asking your care team for advice. Some medications may increase your blood pressure.

Discuss this medication with your care team if you may be pregnant. Serious birth defects can occur if you take this medication during the second and third trimesters. Discuss other treatment options with your care team. There are benefits and risks to taking medications during pregnancy. Your care team can help you find the option that works for you.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions or angioedema—skin rash, itching or hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
  • High potassium level—muscle weakness, fast or irregular heartbeat
  • Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision

Advertisement

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Cough
  • Dizziness
  • Fatigue
  • Headache

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Advertisement

Copyright ©2025 Elsevier Inc. All Rights Reserved.

Terms of use.

Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

Ad