Trolamine Salicylate Cream

Trolamine salicylate is a pain reliever that treats muscle and joint pain. This medication comes as a skin cream. You can apply this cream to your affected skin as directed at regular intervals to relieve your symptoms. Common brand names include Aspercreme® and Blue-Emu® among others.

What is this medication?

TROLAMINE SALICYLATE (TROLE a meen; sa LIS i late) relieves minor pain in your muscles and joints. It works by decreasing inflammation. It belongs to a group of medications called salicylates.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Analgesic Creme Rub with Aloe, Arthritis Pain Med, Asper-Flex, Aspercreme, Blue-Emu, Mobisyl, Myoflex, Sportscreme


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What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Broken, irritated skin
  • Large areas of burned or damaged skin
  • Skin conditions or sensitivity
  • An unusual or allergic reaction to trolamine salicylate, other salicylates (including aspirin), other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

This medication is for external use only. Use your medication at regular intervals. Do not use it more often than directed.

Talk to your care team about the use of this medication in children. While this medication may be used for children as young as 12 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.


What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medication?

Interactions are not expected. Do not use any other skin products on the same area of skin without asking your care team.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.


What should I watch for while using this medication?

Tell your care team if your symptoms do not start to get better or get worse.

Do not get this medication in your eyes. If you do, rinse out with plenty of cool tap water.

This medication may make certain skin conditions worse. Only use it for conditions for which your care team has prescribed.

Do not bandage the area of treated skin tightly or use with a heating pad.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Mild skin irritation, redness, or dryness

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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