What is this medicine?

FLUCONAZOLE (floo KON na zole) is an antifungal medicine. It is used to treat certain kinds of fungal or yeast infections.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Diflucan

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • history of irregular heart beat
  • kidney disease
  • an unusual or allergic reaction to fluconazole, other azole antifungals, medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth. Follow the directions on the prescription label. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. This medicine has been used in children as young as 6 months of age.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • astemizole
  • certain medicines for irregular heart beat like dronedarone, quinidine
  • cisapride
  • erythromycin
  • lomitapide
  • other medicines that prolong the QT interval (cause an abnormal heart rhythm)
  • pimozide
  • terfenadine
  • thioridazine
  • tolvaptan

This medicine may also interact with the following medications:

  • antiviral medicines for HIV or AIDS
  • birth control pills
  • certain antibiotics like rifabutin, rifampin
  • certain medicines for blood pressure like amlodipine, isradipine, felodipine, hydrochlorothiazide, losartan, nifedipine
  • certain medicines for cancer like cyclophosphamide, vinblastine, vincristine
  • certain medicines for cholesterol like atorvastatin, lovastatin, fluvastatin, simvastatin
  • certain medicines for depression, anxiety, or psychotic disturbances like amitriptyline, midazolam, nortriptyline, triazolam
  • certain medicines for diabetes like glipizide, glyburide, tolbutamide
  • certain medicines for pain like alfentanil, fentanyl, methadone
  • certain medicines for seizures like carbamazepine, phenytoin
  • certain medicines that treat or prevent blood clots like warfarin
  • dofetilide
  • halofantrine
  • medicines that lower your chance of fighting infection like cyclosporine, prednisone, tacrolimus
  • NSAIDS, medicines for pain and inflammation, like celecoxib, diclofenac, flurbiprofen, ibuprofen, meloxicam, naproxen
  • other medicines for fungal infections
  • sirolimus
  • theophylline
  • tofacitinib
  • ziprasidone

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checkups. If you are taking this medicine for a long time you may need blood work. Tell your doctor if your symptoms do not improve. Some fungal infections need many weeks or months of treatment to cure.

Alcohol can increase possible damage to your liver. Avoid alcoholic drinks.

If you have a vaginal infection, do not have sex until you have finished your treatment. You can wear a sanitary napkin. Do not use tampons. Wear freshly washed cotton, not synthetic, panties.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash or itching, hives, swelling of the lips, mouth, tongue, or throat
  • dark urine
  • feeling dizzy or faint
  • irregular heartbeat or chest pain
  • redness, blistering, peeling or loosening of the skin, including inside the mouth
  • trouble breathing
  • unusual bruising or bleeding
  • vomiting
  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • changes in how food tastes
  • diarrhea
  • headache
  • stomach upset or nausea

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature below 30 degrees C (86 degrees F). Throw away any medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Copyright ©2020 Elsevier Inc. All Rights Reserved. Terms of Use.

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy