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Lactulose Solution (Constipation)

Lactulose is a laxative made from lactose. It treats chronic constipation. It also treats or prevents hepatic encephalopathy or coma, which are conditions that could result from liver disease.

What is this medication?

LACTULOSE (LAK tyoo lose) treats constipation. It works by increasing the amount of water your intestine absorbs. This softens the stool, making it easier to have a bowel movement. It also increases pressure, which prompts the muscles in your intestines to move stool. It belongs to a group of medications called laxatives.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Acilac, Cephulac, Cholac, Chronulac, Constilac, Constulose, Enulose, Generlac

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What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Need a galactose-free diet
  • Scheduled for surgery
  • An unusual or allergic reaction to lactulose, other sugars, medications, foods, dyes or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

Take this medication mouth. Follow the directions on the prescription label. Shake well before using. Use a specially marked spoon or container to measure your medication. Ask your pharmacist if you do not have one. Household spoons are not accurate. Take your doses at regular intervals. Do not take your medication more often than directed.

You may be directed to take this medication rectally. If so, you must follow specific directions from your care team. Please contact them.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

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What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

  • Antacids
  • Neomycin
  • Other laxatives

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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What should I watch for while using this medication?

This medication may not produce any result for 24 to 48 hours. Do not take this medication for longer than directed by your care team.

Drink plenty of water with each dose of this medication.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Diarrhea
  • Gas
  • Nausea
  • Stomach cramping
  • Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

This medication may darken in color under normal storage conditions. This is because of the sugar solution and does not affect the way the medication works. If the solution becomes extremely dark in color, contact your care team before use.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Do not freeze. Keep container tightly closed. Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Copyright ©2024 Elsevier Inc. All Rights Reserved.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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