Lidocaine; Hydrocortisone Skin Cream or Lotion

Lidocaine hydrocortisone is a cream you put on your skin to reduce swelling, itching and pain from skin irritations like minor scrapes and burns and hemorrhoids. It’s available through prescription only.

What is this medication?

LIDOCAINE; HYDROCORTISONE (LYE doe kane; hye droe KOR ti sone) is an anesthetic pain reliever combined with a corticosteroid. It is used to decrease swelling, itching, and pain that is caused by minor skin irritations or hemorrhoids.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Ana-Lex HC, AnaMantle HC, AnaMantle-HC Forte, DermacinRx Radiaura, LidaMantle HC, LidaZone HC, LidoCort, Lidosol-HC, Peranex HC, Senatec HC

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What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • large areas of burned or damaged skin
  • liver disease
  • skin infection (especially a virus infection such as chickenpox, cold sores, or herpes
  • skin wasting or thinning
  • tuberculosis
  • an unusual or allergic reaction to lidocaine, hydrocortisone, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medication?

This medicine is for external use only. Do not take by mouth. Follow the directions on the prescription label. Wash your hands before and after use. Do not cover with a bandage or dressing unless your doctor or health care professional tells you yo. Use your medicine at regular intervals. Do not use it more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

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What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medication?

  • certain medicines for irregular heart beat

Do not use any other skin products on the same area of skin without asking your doctor or health care professional.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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What should I watch for while using this medication?

Tell your doctor or health care professional if your symptoms do not start to get better or if they get worse.

Do not get this medicine in your eyes. If you do, rinse out with plenty of cool tap water.

This medicine can make certain skin conditions worse. Only use it for conditions for which your doctor or health care professional has prescribed.

Be careful to avoid injury to the treated skin while the area is numb and you are not aware of pain.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • burning feeling on the skin
  • confusion
  • dizziness
  • infection
  • lack of healing of skin conditions
  • painful, red, pus-filled blisters in hair follicles
  • palpitations
  • thinning of the skin
  • tremor

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • dry skin, irritation
  • unusual increased growth of hair on the face or body

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Copyright ©2024 Elsevier Inc. All Rights Reserved.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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