Potassium Phosphate; Sodium Phosphate Tablets

What is this medication?

POTASSIUM PHOSPHATE; SODIUM PHOSPHATE (poe TASS ee um FOS fate; SOE dee um FOS fate) prevents kidney stones caused by too much calcium in the body. It works by making your urine more acidic, which prevents the build up of calcium. It may also be used to prevent and treat low phosphorus levels in your body. Phosphorus is a mineral that plays an important role in maintaining the health of your bones, muscles, digestive tract, and nervous system. This medication can also help antibiotics for UTIs work better.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Av-Phos, K-Phos M.F., K-Phos Neutral, K-Phos No 2, Phospha 250 Neutral, Phospho-Trin, Uro-Kp-Neutral, Virt-Phos 250 Neutral


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What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Addison's disease
  • Dehydration
  • Heart disease
  • High levels of phosphate, potassium, or sodium in the blood
  • Kidney disease
  • Kidney stones
  • Low sodium diet
  • An unusual or allergic reaction to phosphorus, potassium, sodium, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

Take this medication by mouth with a full glass of water. Take it as directed on the label at the same time every day. Keep taking it unless your care team tells you to stop.

Talk to your care team about the use of this medication in children. While this medication may be prescribed for children as young as 4 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.


What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

Do not take this medication with any of the following:

  • Burosumab
  • Eplerenone
  • Sevelamer

This medication may also interact with the following:

  • Antacids or other products that contain aluminum, magnesium, or calcium
  • Certain medications for blood pressure or heart disease like lisinopril, losartan, quinapril, valsartan
  • Diuretics such as spironolactone, triamterene
  • Iron supplements
  • Magnesium supplements
  • Medications that lower your chance of fighting infection such as cyclosporine, tacrolimus
  • Other products that contain potassium or phosphorus
  • Salt substitutes
  • Vitamin D supplements

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.


What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Your care team may order blood work while you are taking this medication.

You may pass a kidney stone after starting this medication. Contact your care team if you have new or unusual symptoms.

Follow a healthy diet. Taking this medication does not replace the need for a balanced diet.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • High phosphorus level—muscle pain or cramps, bone or joint pain, numbness and tingling around the mouth
  • High potassium level—muscle weakness, fast or irregular heartbeat
  • High sodium level—confusion, increased thirst, muscle weakness, unusual weakness or fatigue, twitching muscles

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Bone or joint pain
  • Diarrhea
  • Dizziness
  • Fatigue
  • Headache
  • Nausea
  • Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from light. Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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