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Nafarelin Nasal Spray

Nafarelin is a synthetic hormone that works to lower the amount of testosterone or estrogen in your body. It treats endometriosis and precocious puberty. This medication comes as a nasal spray. Follow the instructions on the label to use this medication in your nose.

What is this medication?

NAFARELIN (naf A re lin) treats the symptoms of endometriosis. It works by decreasing the amount of estrogen your body makes, which reduces heavy bleeding and pain. It may also be used to treat a condition that causes early puberty. It works by decreasing levels of the hormones estrogen and testosterone in the body. This slows or stops signs of puberty while you are taking this medication.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Synarel

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Depression
  • Mental health conditions
  • Osteoporosis, weak bones
  • Polycystic ovary syndrome
  • Seizures
  • Unusual vaginal bleeding
  • An unusual or allergic reaction to nafarelin, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

This medication is for use in the nose. Use it as directed on the prescription label at the same time every day. Do not use it more often than directed. Make sure that you are using your nasal spray correctly. Ask your care team if you have any questions.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

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What may interact with this medication?

Do not take this medication with any of the following:

  • Supplements, such as chasteberry

This medication may also interact with the following:

  • Other nasal sprays

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Your symptoms may get worse for a short time after starting this medication. Talk to your care team if your symptoms do not get better.

Using this medication for a long time may weaken your bones. The risk of bone fractures may be increased. Talk to your care team about your bone health.

If you use a decongestant nose spray, wait for 2 hours after using this medication to use the decongestant spray.

Use a non-hormonal method of contraception while taking this medication. If you think you might be pregnant, call your care team.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Increased pressure around the brain—severe headache, blurry vision, change in vision, nausea, vomiting
  • Seizures
  • Vaginal discharge
  • Worsening mood, feelings of depression

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Acne
  • Body odor
  • Change in sex drive or performance
  • Hot flashes
  • Irregular menstrual cycles or spotting
  • Mood swings, irritability, hostility
  • Runny or stuffy nose
  • Unexpected breast tissue growth

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Store bottle right side up. Protect from light. Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer wanted or have expired:

  • Take the medication to a medication take-back program. Ask your pharmacy or law enforcement to find a location.
  • If you cannot return the medication, ask your pharmacist or care team how to get rid of the medication safely.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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