Cefazolin Injection

What is this medication?

CEFAZOLIN (sef A zoe lin) is a cephalosporin antibiotic. It treats some infections caused by bacteria. It will not work for colds, the flu, or other viruses.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Ancef, Kefzol

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What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

•bleeding problems

•diarrhea

•kidney disease

•liver disease

•stomach or intestine problems (especially colitis)

•an unusual or allergic reaction to cefazolin, other cephalosporin antibiotics, penicillin, penicillamine, other foods, dyes or preservatives

•pregnant or trying to get pregnant

•breast-feeding

How should I use this medication?

This drug is injected into a muscle or a vein. It is usually given by a health care provider in a hospital or clinic setting.

If you get this drug at home, you will be taught how to prepare and give it. Use exactly as directed. Take it as directed on the prescription label at the same time every day. Keep taking it unless your health care provider tells you to stop.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or health care provider to get one.

Talk to your health care provider about the use of this drug in children. While it may be prescribed for children as young as 1 month for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

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What if I miss a dose?

It is important not to miss your dose. Call your health care provider if you are unable to keep an appointment. If you give yourself this drug at home and you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

•birth control pills

•blood thinners

•other antibiotics

•probenecid

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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What should I watch for while using this medication?

Tell your doctor or health care provider if your symptoms do not get better in a few days.

This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine. Contact your health care provider right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.

If you have diabetes you might get a false-positive result for sugar in your urine. Check with your doctor or health care provider before you change your diet or the dose of your diabetes medicine.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • fever or chills
  • redness, blistering, peeling or loosening of the skin, including inside the mouth
  • seizures
  • severe or watery diarrhea
  • sore throat
  • stomach pain or cramps
  • trouble passing urine or change in the amount of urine
  • unusual bleeding or bruising

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea
  • genital or anal irritation
  • loss of appetite
  • nausea, vomiting
  • pain or redness where injected

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

You will be instructed on how to store this drug. Protect from light. Throw away any unused drug after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Copyright ©2024 Elsevier Inc. All Rights Reserved.

Terms of use.

Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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