Letermovir injection

What is this medication?

Letermovir (let er' moe vir) is an antiviral medicine. It is used to prevent infections caused by certain kinds of viruses.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Prevymis

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• kidney disease
• liver disease
• an unusual or allergic reaction to letermovir other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medication?

This medicine is for infusion into a vein. It is usually given by a health care professional in a hospital or clinic setting. If you get this medicine at home, you will be taught how to prepare and give this medicine. Use exactly as directed. Take your medicine at regular intervals. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

Do not take this medicine with any of the following medications:

• bosentan
• certain medicines for HIV or AIDS like efavirenz, etravirine, nevirapine
• certain medicines for infection like nafcillin, rifabutin, rifampin
• certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
• ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
• modafinil
• pimozide
• St. John's Wort
• thioridazine

This medicine may also interact with the following medications:

• alfentanil
• amiodarone
• certain medicines for cholesterol like atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin
• certain medicines for diabetes, like glyburide, repaglinide, rosiglitazone
• certain medicines for stomach problems like omeprazole, pantoprazole
• certain medicines that treat or prevent blood clots like warfarin
• cyclosporine
• fentanyl
• midazolam
• quinidine
• sirolimus
• tacrolimus
• voriconazole

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

You may need blood work done while you are taking this medicine.

Your condition will be monitored carefully while you are receiving this medicine.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue)

Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):

• cough
• diarrhea
• headache
• nausea, vomiting
• stomach pain
• swelling of the ankles, feet, hands
• tiredness

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children.

This drug is usually given in a hospital or clinic and will not be stored at home.

In rare cases, this medicine may be given at home. If you are using this medicine at home, you will be instructed on how to store this medicine. Throw away any unused medicine after the expiration date on the label.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.