Details

IRB Study Number 25-509

Status Recruiting

Locations Cleveland Clinic Weston Hospital , Cleveland Clinic Main Campus

Institute Digestive Disease & Surgery Institute

Description

Description

This study is for adults who take a GLP-1 or GIP agonist (medication for diabetes or weight loss) and are scheduled for an outpatient colonoscopy.

The goal is to find out whether holding one dose of the medication before colonoscopy actually improves bowel preparation, or if it is just as safe and effective to continue the medication as usual. The study will also look at colonoscopy quality (how clean the bowel is, how many polyps are found, how long the procedure takes) and any breathing problems after the procedure, such as pneumonia or aspiration.

If you join, you will be randomly assigned (like a coin flip) to one of two groups:

  • Continue group: keep taking your GLP-1 / GIP medicine as prescribed,

  • Hold group: skip one dose before the colonoscopy (the dose right before the procedure).

Everyone in the study:

  • Gets the same standard bowel prep and diet instructions,

  • Has a routine colonoscopy with the usual team,

  • Has their bowel prep scored using standard scales, and

  • Gets a follow-up phone call 2–4 days after the procedure to check for any problems.

No extra scopes, blood tests, or clinic visits are done just for the study.

Inclusion Criteria

Inclusion Criteria

  • Age 18 years or older

  • Scheduled for an outpatient colonoscopy (screening, surveillance, or diagnostic)

  • Currently using a GLP-1 or GIP agonist (for diabetes or weight loss) at a stable dose for at least 1 month

Exclusion Criteria

Exclusion Criteria

  • Unable to provide informed consent (for example, moderate or severe dementia)

  • Do not agree to follow the recommended bowel prep and diet for this study

  • split-dose 4L polyethylene glycol (PEG) + 15 mg bisacodyl

  • low-residue diet for 3 days before colonoscopy

  • clear-liquid diet the day before colonoscopy FileDownload (50)

  • Have other strong risk factors for poor bowel prep besides diabetes or obesity, such as:

  • Cirrhosis

  • Parkinson’s disease

  • Dementia

  • Regular use of tricyclic antidepressants

  • Regular opioid use

  • Gastroparesis or suspected gastric outlet obstruction

    • proven by a gastric emptying study, imaging, or prior retained contents during endoscopy

  • Previous colorectal surgery

  • Prior history of inadequate bowel preparation for colonoscopy