Invest in Transformative Ideas

Centerline’s Intra-Operative Positioning System (IOPS) is a platform technology that enhances visualization and navigation across a range of endovascular procedures, while reducing exposure to harmful radiation for patients and physicians.

Enspire DBS Therapy aims to revitalize stroke recovery using deep brain stimulation alongside physical rehabilitation to restore motor function for stroke survivors living with disability.

Infuseon Therapeutics, founded in 2012, enables reliable delivery of therapeutics to the brain via a proprietary multiport convection-enhanced delivery catheter, designed by a Cleveland Clinic neurosurgeon to more effectively deliver life-saving drugs to patients at the site of disease.

MediView is empowering clinicians with “X-Ray Vision” digitally assisted surgery powered by augmented reality, telepresence, and data-driven insights. By simplifying procedures with this “X-Ray Vision”, healthcare delivery can be simplified, democratized, and informed.

Method AI is developing a surgical navigation platform to drive improved patient outcomes for robotic oncology procedures. The company’s product will leverage deep tissue imaging and machine learning algorithms to provide physicians with real-time guidance against an AI-generated surgical plan.

Mitria Medical is developing a minimally invasive transcatheter mitral valve repair implant.

XII Medical is developing a minimally-invasive outpatient technology for the treatment of obstructive sleep apnea (OSA).

Abcon Therapeutics is developing an antibody-drug conjugate (ADC) that targets the CD6 cell surface protein on T-cells. In pathogenic conditions, such as T-cell lymphoma and inflammatory conditions, the ADC binds to all T-cells, but the drug (toxin) only affects activated dividing T-cells (i.e. the cancerous ones in T-Cell Lymphoma) so these are killed, and normal inactive T-cells are spared. CD6 is found exclusively on T-cells; thus, the ADC specificity is very good. The Company plans to develop a pipeline of ADCs targeting different types of cancer.

This first of its kind PSMA-targeted peptidomimetic for diagnostic imaging and radionuclide treatment of prostate cancer with a novel linker region that reduces accumulation in salivary gland tissue mitigating dose-limiting severe dry mouth side effects.

AxoNeural focuses on improving the treatment of neurodegenerative injuries and diseases, as a result of traumatic spinal cord injuries, using nanoparticle delivered therapeutics. These nanoparticles reduce inflammation, protect nerve fibers, and promote tissue healing, potentially improving motor and sensory functions.

Cell X Technologies provides novel tools and approaches to select and maintain cell populations for gene and cell therapies and tissue engineered products, accelerating product understanding, reducing the risk of product approval failure and speeding the path to clinical impact for cell therapies by combining robotics, imaging, and artificial intelligence.

Cleveland Diagnostics is a biotechnology company with proprietary first-in-class technology and reagents to enable development of high efficacy and affordable tests, focused on early detection and diagnostics of cancer and neurodegenerative diseases.

Mobius is personalizing Inflammatory Bowel Disease (IBD) therapeutic and diagnostic care, through its proprietary AI tool, applied to targeting host and microbiome pathways that infect gastrointestinal (GI) tract wounds. The Company’s technology can also identify subsets of patients who are likely to respond favorably to an existing arsenal of well-characterized drug candidates. Additionally, Mobius is developing therapeutics to treat the dysfunctional wound healing and dysfunctional microbiome associated with IBD.

NeuroTherapia is a clinical stage biotechnology company developing novel therapies that decrease the neuroinflammation associated with diseases such as neuropathic pain and Alzheimer’s disease.

Steelhead Therapeutics is a preclinical-stage biotechnology company developing engineered nanobody‑based complement inhibitors for the treatment of complement‑mediated diseases. Its novel platform enables precise upstream modulation of the complement cascade to enable improved safety and therapeutic profiles. The company is advancing lead program, STL-001, as a potential best-in-class functional inhibitor of C2 for the treatment of the classical and lectin pathways. Funding will support the progression of its lead candidate through Phase Ia and Ib clinical studies.

Zehna Therapeutics is an early-stage biotech company focused on developing novel, non-bacteriocidal inhibitors of selected gut microbial pathways clinically and mechanistically linked with chronic metabolic diseases such as Chronic Kidney Disease and cardiovascular disease. The Company’s lead compounds inhibit the gut microbial enzyme CutC, preventing the conversion of dietary choline to trimethylamine (TMA) and subsequently to trimethylamine N-oxide (TMAO). Increased levels of TMAO, metabolized and secreted by gut bacteria, in the host results in a dose-dependent increase in poor outcomes in clinical studies and animal models.

1m is a data and analytics technology company serving large healthcare organizations through a B2B SaaS model. The company is setting the standard for risk management in healthcare, with an end-to-end risk management and data monitoring platform designed for Enterprise Risk, Internal Audit, Compliance, and Finance teams.

Ayble Health is a virtual care platform empowering patient with chronic gastrointestinal (GI) conditions to improve their symptoms and live fuller lives. Ayble’s platform includes unlimited access to a GI-specialized multidisciplinary care team, a suite of AI-powered nutrition and psychology programs, and curated wellness tools to drive sustainable symptom improvement for patients across the entire spectrum of acuity.

Bayesian Health provides an artificial intelligence/machine learning platform for hospitals to predict declining patient trajectories, such as sepsis detection. The research-backed platform delivers accurate, actionable clinical signals within the electronic medical record and existing workflows, enabling care teams to identify risk and detect life-threatening complications earlier, thereby improving patient outcomes.

Ceraxis Health has developed a platform for longitudinal tracking of symptoms and management to address patient functional health, quality of life outcomes and treatment planning and monitoring through real-time, data-driven care management for neurological conditions such as Parkinson’s Disease.

Dyania Health is an AI-driven healthcare data company that unlocks valuable insights from unstructured clinical data. Through its Synapsis AI platform, Dyania Health automates the reading, understanding, and analysis of complex medical data, enabling more efficient and optimal clinical research, reporting, and quality within healthcare institutions.

Floreo is a virtual reality therapy modality to enable immersive/experiential learning to accommodate and support individuals with a variety of different neurological profiles. The learner follows clinician-designed lessons and guidance to build social, communication, behavioral, emotional regulation, safety and adaptative life skills. Digital delivery and personalized interventions supplement the in-clinic standard of care , increasing accessibility and flexibility for learners. In 2024, Floreo acquired Autism Eyes, a Cleveland Clinic portfolio company, to enhance the portfolio by incorporating proprietary diagnostics and patient monitoring technology. As part of the transaction, Cleveland Clinic also made a strategic investment in Floreo.

Sports Data Labs (SDL) is a leader in AI-based collection, analysis and distribution of real-time human data from on-body sensors and sensing systems, as well as other data sources. SDL provides patented and other proprietary technologies that empower individuals to collect, control, and distribute their personal data, while using AI to transform collected data into metrics, insights and predictions for various real-time and on-demand use cases.

Xealth is a digital health prescribing platform that enables clinicians to easily integrate, prescribe, and monitor digital health tools for patients from their EHR workflows.