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We welcome potential partners to learn more about our new companies featuring next-generation medical products.

Our Companies

Our diverse portfolio of more than 40 spinoff companies showcases our mission to make the latest scientific discoveries and inventions available to patients around the world. A dedicated team of business experts supports our ventures throughout their life cycle, from formation, management and governance to funding and potential acquisition. Startup companies can access our state-of-the-art technology Incubator, as well as the Cleveland Clinic and Lerner Research Institute’s vast resources for research and testing.

Featured Companies

Our portfolio includes a wide range of venture technology companies, including medical devices, pharmaceuticals, diagnostics and digital health at a range of development stages.

Cleveland Diagnostics

Cleveland Diagnostics, Inc is a commercial stage company developing next generation diagnostic tests for the early detection of cancer using its proprietary technology The Company’s Solvent Interaction Analysis™ (technology investigates blood based protein biomarkers at the structural level (vs only biomarker concentration), providing additional insights regarding the protein origin on the cellular level, thus improving test specificity. Its IsoPSA® test provides differentiated, actionable information to identify the likelihood of high grade prostate cancer and utility of performing a biopsy following a positive screening.

Centerline Biomedical®

FDA-cleared endovascular navigation technology makes procedures safer, faster and more precise. A GPS-like tracking system for medical procedures reduces radiation exposure, allows intraoperative 3D visualization and provides real-time guidance of catheters and guidewires.

Avaneer Health®

A secure and trusted network for providers and payers to enable data interoperability through a decentralized platform infrastructure. The technology transformation was led by top healthcare institutions to automate and simplify partner workflows to improve health experience, efficiency and transparency for data-sharing. Founding members including CVS Health, Elevance, HCSC, Sentara, PNC and Cleveland Clinic cover over 80 million lives in the network.

Learn More About Our Companies

Contact us to learn more about investing with Cleveland Clinic Innovations.

Medical Device Companies

Medical Device Companies

Cardionomic Logo


Cardionomic is developing a neuromodulation device for the management of acute decompensated heart failure (ADHF) by improving cardiac output via improved contractility. The inpatient cost of ADHF care is extremely high – accounting for 60% of total heart failure expenditures.

Centerline Biomedical logo

Centerline Biomedical

Centerline’s Intra-Operative Positioning System (IOPS) is a platform technology that enhances visualization and navigation across a range of endovascular procedures, while reducing exposure to harmful radiation for patients and physicians.

Enspire DBS Therapy logo

Enspire DBS Therapy

Enspire DBS Therapy aims to revitalize stroke recovery using deep brain stimulation alongside physical rehabilitation to restore motor function for stroke survivors living with disability.

Infuseon Therapeutics logo

Infuseon Therapeutics, Inc.

Infuseon Therapeutics, founded in 2012, enables reliable delivery of therapeutics to the brain via a proprietary multiport convection-enhanced delivery catheter, designed by a Cleveland Clinic neurosurgeon to more effectively deliver life-saving drugs to patients at the site of disease.

MediView XR, Inc.

MediView XR, Inc.

MediView is empowering clinicians with “X-Ray Vision” digitally assisted surgery powered by augmented reality, telepresence, and data-driven insights. By simplifying procedures with this “X-Ray Vision”, healthcare delivery can be simplified, democratized, and informed.

Method AI logo

Method AI

Method AI is developing a surgical navigation platform to drive improved patient outcomes for robotic oncology procedures. The company’s product will leverage deep tissue imaging and machine learning algorithms to provide physicians with real-time guidance against an AI-generated surgical plan.

Mitria Medical logo

Mitria Medical

Mitria Medical is developing a minimally invasive transcatheter mitral valve repair implant.

NaviGate Cardiac Structures logo

NaviGate Cardiac Structures

NaviGate Cardiac Structures Inc. (NCSI) is developing transcatheter tricuspid valve replacement solution for the treatment of tricuspid regurgitation. Exited to a strategic in March 2024.

Perfusion Solutions

Perfusion Solutions

Perfusion Solutions is developing a minimally-invasive implantable ultra-small heart pump technology for acute and chronic heart failure.

XII Medical logo

XII Medical

XII Medical is developing a minimally-invasive outpatient technology for the treatment of obstructive sleep apnea (OSA).

Therapeutics & Diagnostics Companies

Therapeutics & Diagnostics Companies

Abcon Therapeutics logo

Abcon Therapeutics

Abcon Therapeutics is developing an antibody-drug conjugate (ADC) that targets the CD6 cell surface protein on T-cells. In pathogenic conditions, such as T-cell lymphoma and inflammatory conditions, the ADC binds to all T-cells, but the drug (toxin) only affects activated dividing T-cells (i.e. the cancerous ones in T-Cell Lymphoma) so these are killed, and normal inactive T-cells are spared. CD6 is found exclusively on T-cells; thus, the ADC specificity is very good. The Company plans to develop a pipeline of ADCs targeting different types of cancer.

Cleveland Diagnostics logo

Cleveland Diagnostics

Cleveland Diagnostics is a biotechnology company with proprietary first-in-class technology and reagents to enable development of high efficacy and affordable tests, focused on early detection and diagnostics of cancer and neurodegenerative diseases.

Mobius Care logo

Mobius Care, Inc.

Mobius is personalizing Inflammatory Bowel Disease (IBD) therapeutic and diagnostic care, through its proprietary AI tool, applied to targeting host and microbiome pathways that infect gastrointestinal (GI) tract wounds. The Company’s technology can also identify subsets of patients who are likely to respond favorably to an existing arsenal of well-characterized drug candidates. Additionally, Mobius is developing therapeutics to treat the dysfunctional wound healing and dysfunctional microbiome associated with IBD.

NeuroTherapia logo


NeuroTherapia is a clinical stage biotechnology company developing novel therapies that decrease the neuroinflammation associated with diseases such as neuropathic pain and Alzheimer’s disease.

Zenha Therapeutics logo

Zehna Therapeutics

Zehna Therapeutics is an early-stage biotech company focused on developing novel, non-bacteriocidal inhibitors of selected gut microbial pathways clinically and mechanistically linked with chronic metabolic diseases such as Chronic Kidney Disease and cardiovascular disease. The Company’s lead compounds inhibit the gut microbial enzyme CutC, preventing the conversion of dietary choline to trimethylamine (TMA) and subsequently to trimethylamine N-oxide (TMAO). Increased levels of TMAO, metabolized and secreted by gut bacteria, in the host results in a dose-dependent increase in poor outcomes in clinical studies and animal models.

Digital Health Companies

Digital Health Companies

Autism Eyes logo

Autism Eyes

The Autism Eyes™ platform accelerates the time to diagnosis for children with autism, and drives clinical workflow efficiency, by providing a rapid, objective assessment of autism risk. Current diagnostic processes are subjective and lengthy, resulting in patient backlogs of up to twelve months. Well-established research indicates that earlier ASD diagnosis leads to improved outcomes. Autism Eyes addresses a clear unmet need by streamlining clinical workflow to enable earlier diagnosis, earlier treatment access, and in turn, improved outcomes. Acquired by Floreo in March 2024.

Avaneer Health logo

Avaneer Health

Avaneer Health was founded by leaders with the vision to transform how healthcare shares information via a unique, interoperable network designed by and for healthcare. Avaneer streamlines healthcare administration where health information can be shared in real-time, with permission, and in control of the owner or steward of the data, leveraging collaboration services for identity, workflow, zero trust security, and solution marketplace.

Bering Health Logo

Bering Health, Inc.

Bering Health is a digital health start-up that will provide virtual care for low-acuity and low-complexity medical conditions. Individuals will be able to utilize the Company’s digital platform in a convenient setting, such as at home, yet it will still be integrated with an individual’s local provider, thereby maintaining continuous care and up-to-date medical records.

Ceraxis logo

Ceraxis Health, Inc.

Ceraxis Health has developed a platform for longitudinal tracking of symptoms and management to address patient functional health, quality of life outcomes and treatment planning and monitoring through real-time, data-driven care management for neurological conditions such as Parkinson’s Disease.

Qr8 Health logo

Qr8 Health

Qr8 Health is a digital health company providing standardized, validated, patient-self-administered assessments for the measurement of neurological and motor function along with patient-reported outcomes administered on a mobile tablet device and easily integrated into electronic health records. Founded in 2016, the company has developed applications enabling transformational improvement in patient care by providing medical solutions for collecting highly standardized clinical data and patient-reported outcomes, in any medical or home setting.

Xealth logo


Xealth is a digital health prescribing platform that enables clinicians to easily integrate, prescribe, and monitor digital health tools for patients from their EHR workflows.

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