Advance Healthcare Innovation with Cleveland Clinic
Cleveland Clinic Innovations transforms breakthrough healthcare technologies from our caregivers into patient impact through commercialization, licensing, startup creation and strategic industry partnerships.
Since 2000, we’ve delivered:
- 2800+ patents issued
- 950+ licenses executed
- 109 startups launched
- 29 company exits
Every medical innovation starts with a problem facing patients, caregivers, or healthcare systems. Cleveland Clinic Innovations transforms insights into technologies that improve lives around the world. Our portfolio spans medical devices, diagnostics, therapeutics, digital health and AI-driven solutions. Across our Cleveland Clinic ecosystem, we are moving healthcare breakthroughs from discovery to patient care with our current pipeline of technologies featuring innovations at the cutting edge of endo-robotics, CAR T therapy, neurosurgery and more.
What We Do
Cleveland Clinic Innovations helps companies and entrepreneurs identify, develop, and commercialize breakthrough healthcare technologies that improve patient outcomes and safety, expand access to care and reduce the cost of healthcare.
Working alongside world-renowned clinicians, researchers, philanthropists and industry leaders, we are transforming promising ideas into solutions that address the most pressing healthcare challenges. We bring innovations to market through:
- Medical technology licensing across medical devices, diagnostics, therapeutics, digital health and technologies powered by artificial intelligence
- Healthcare startup creation, venture development and investing
- Strategic co-development partnerships that accelerate delivery and adoption
- Industry partnerships to solve unmet clinical needs
- Intellectual property and commercialization expertise
- Investment opportunities evaluated and advanced within a leading global healthcare system
- Philanthropic partnerships that advance promising technologies for rare and complex diseases
Why Partners Choose Us
Cleveland Clinic Innovations is more than a tech transfer office. We operate within Cleveland Clinic’s globally integrated health system, where industry partners, entrepreneurs and investors can work alongside clinicians and researchers to solve healthcare’s greatest unmet needs. Our work is rigorously evaluated and shaped by some of the most complex cases in medicine across the world.
From discovery to commercialization, innovations benefit from real-world clinical insight, scientific rigor, and access to diverse patient populations across our global ecosystem.
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Global Healthcare Innovation Ecosystem
At Cleveland Clinic, discovery happens across specialties and across our global locations, including Ohio, Florida, Nevada, Toronto, London and Abu Dhabi. As one of the world’s leading research hospitals, our clinical expertise, robust research resources and diverse patient populations and data, accelerate innovations from bench to bedside, with real-world validation to accelerate solutions from concept to execution.
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Innovation Driven by Caregivers
The best innovations begin at the frontline. Every day, physicians, nurses, scientists, engineers and caregivers across Cleveland Clinic identify opportunities to improve healthcare delivery. We help transform those insights into new technologies, companies, and solutions by connecting innovators with the expertise, resources, and strategic support needed to reach patients worldwide.
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Integrated Commercialization Expertise
From idea to market, we help innovations navigate every stage of commercialization. Our multidisciplinary team brings expertise in product development, licensing, intellectual property, regulatory strategy and company formation. With tailored commercialization pathways, we’re reducing risk, accelerating development timelines and positioning innovations for long-term success, at scale.
Our Story
For more than 100 years, Cleveland Clinic physicians and researchers have advanced medical discoveries that have improved patient care around the world. In 2000, Cleveland Clinic Innovations was formed as Cleveland Clinic’s commercialization arm. We connect discoveries that solve healthcare’s greatest unmet needs with business opportunities to bring them to market. For decades, innovations that started here have changed medicine:
- 1948: Discovery of serotonin, a neurotransmitter that affects body and mood
- 1958: Development of coronary angiography to reveal artery blockages
- 1980: Discovery of a brain-mapping technique to pinpoint epileptic seizures
- 2008: First U.S. near-total face transplant performed
- 2017: First deep brain stimulation for stroke recovery performed
- 2021: Development of a vaccine to prevent deadly triple-negative breast cancer
- 2025: Development of an automated cardiac MRI that enables free-breathing imaging
