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Cancer Clinical Trials

The cure rate for childhood cancer has improved greatly in the last two decades largely because of treatment in national clinical trials.

Clinical trials are designed to test new and potentially better treatments against those treatments considered standard in the hope of finding better treatments for childhood cancer and related disorders. Clinical trials are ongoing in most parts of the country for most types of childhood cancer. The good news is that Children's Oncology Group clinical trials are closely overseen by a data monitoring committee. As soon as one treatment is found to work more effectively than another, the treating physicians are notified immediately, and your child's treatment changed immediately, if necessary.

The following is a list of open clinical trials available at Children's Department of Pediatric Hematology/Oncology as of April 2015. This list is constantly changing, so please contact Principal Investigator Dr. Megan Burke at 216.444.5517 to discuss your child's needs with us.

Pediatric Hematology Oncology Clinical Trials

Bone Marrow Transplant
  • FHCRC 2064 Pediatric Nonmyeloablative Hematopoietic Cell Transplantation for Patients with Fanconi Anemia Using Alternative Marrow Donors: A Phase I/II Dose-Finding Study
  • FHCRC 2007 Pediatric Hematopoietic cell transplantation for treatment of patients with primary immunodeficiencies and other nonmalignant inherited disorders using low-dose TBI and fludarabine with or without Campath
Brain Tumor Trials

  • ACNS02B3 A Children's Oncology Group Protocol for Collecting and Banking Pediatric Brain Tumor Research Specimens
  • ACNS0332 Efficacy of Carboplatin Administered Concomitantly with Radiation and Iso tretinion as a Pro-Apoptotic Agent in Other Than Average Risk Medulloblastoma
  • ACNS0822 A Randomized Phase II/III Study of Vorinostat (IND# 71976) and Local Irradiation OR Temozolomide and Local Irradiation OR Bevacizumab (IND# 7921) and Local Irradiation Followed by Maintenance Bevacizumab and Temozolomide in Children with Newly Diagnosed High-Grade Gliomas: A Groupwide Phase II/III Study (NCI)
  • Temozolomide with Irinotecan versus Temozolomide, Irinotecan plus Bevacizumab (NSC#704865, IND#7921) for Recurrent/Refractory Medulloblastoma/CNS PNET of Childhood, A COG Randomized Phase II Screening Trial
  • ACNS0831 Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymom ages 1-21 Years
  • IRB 5181 Central Nervous System Atypical Teratoid/Rhabdoid Tumor Registry
  • ACNS1123, Phase 2 Trial of Response-Based Radiation Therapy for Patients with Localized Central Nervous System Germ Cell Tumors
Hepatoblastoma Trials
  • AHEP0731 Treatment of Children with All Stages of Hepatoblastoma: A Groupwide Phase III Study
Hodgkin Disease Trials
  • AHOD04B1 Hodgkin Disease Banking Study
  • AHOD1331, A Randomized Phase III Study of Brentuximab Vedotin (SGN-35, IND #117117) for Newly Diagnosed High-Risk Classical Hodgkin Lymphoma (cHL) in Children and Adolescents
Leukemia, Acute Lymphoblastic Leukemia Trials
  • AALL0631 A Phase III Study of Risk Directed Therapy for Infants with Acute Lymphoblastic Leukemia (ALL): Randomization of Highest Risk Infants to Intensive Chemotherapy +/- FLT3 Inhibition (CEP-702, Lestaurtinib; IND #76431, NSC #617807)
  • AALL05B1 A Children's Oncology Group Protocol for Collecting and Banking Relapsed Acute Lymphoblastic Leukemia Research Specimens
  • AALL1131 A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Testing Clofarabine (IND #73789, NSC# 606869) in the Very High Risk Stratum
  • AALL08B1 Classification of Newly Diagnosed Acute Lymphoblastic Leukemia
  • AALL0932 Treatment of Patients with Newly Diagnosed Standard Risk B-precursor Acute Lymphoblastic Leukemia
  • ACCL0934 A Randomized Trial of Levofloxacin to Prevent Bacteremia in Children Being Treated for Acute Leukemia (AL) or Undergoing Hematopoietic Stem Cell Transplantation (HSCT)
Leukemia, Acute Myelogenic Leukemia Trials
  • AAML0531 A Phase III Randomized Trial of Gemtuzumab Ozogamicin (Mylotarg®) Combined with Conventional Chemotherapy for De Novo Acute Myeloid Leukemia (AML) in Children, Adolescents, and Young Adults
  • AAML08B1 Biology STudy of Transient Myeloproliferative Disorder (TMD) in Children with Down Syndrome (DS)
  • ACCL0931 A Randomized Open-Label Trial of Caspofungin versus Fluconazole to Prevent Invasive Fungal Infections in Children Undergoing Chemotherapy for Acute Myeloid Leukemia (AML): A Groupwide Phase III Study"
  • AAML1031 A Phase III Randomized Trial for Patients with de novo AML using Bortezomib and Sorafenib (IND#114480; NSC# 681239, NSC# 724772) for Patients with High Allelic Ratio FLT3/ITD Lymphoma
Lymphoma Trials
  • ANHL0131 A Phase III Trial of Treatment of Advanced State Anaplastic Large Cell Lymphoma with Standard APO (Doxorubicin, Prednisone, Vincristine) versus Consolidation with a Regimen Including Vinblastine
  • ANHL04B1 Rare and Cutaneous Non-Hodgkin's Lymphoma Registry
  • ANHL1131 Intergroup Trial for Children or Adolescents with B-cell Non-Hodgkin Lymphoma NHL or Mature B-cell Leukemia B- AL: Evaluation of Rituximab (IND #10385) Efficacy and Safety in High Risk Patients
Neuroblastoma Trials
  • ANBL00B1 Neuroblastoma Biology Studies
  • ANBL0032 Phase III Randomized Study of Chimeric Anti-GD2 in High-Risk Neuroblastoma Following Myeloablative Therapy and Autologous Stem Cell Rescue
  • ANBL12P1 Pilot Study Using Myeloablative Busulfan/Melphalan (BuMel) Consolidation Following Induction Chemotherapy for Patients with Newly Diagnosed High-Risk Neuroblastoma
Non-Hodgkins Trials
  • ANHL1131, Intergroup Trial for Children or Adolescents with B-cell Non-Hodgkin Lymphoma NHL or Mature B-cell Leukemia B- AL: Evaluation of Rituximab (IND #10385) Efficacy and Safety in High Risk Patients
Pediatric Solid Tumor Trials
  • ADVL0524 A Phase II Study of Ixabepilone (BMS-247550), an Epothilone B Analog, in Children and Young Adults with Refractory Solid Tumors
  • AEWS02B1 A Groupwide Biology and Banking Study for Ewing Sarcoma
  • AEWS02P1 A Pilot Study of Low-Dose Antiangiogenic Chemotherapy in Combination with Standard Multiagent Chemotherapy for Patients with Newly Diagnosed Metastatic Ewing Sarcoma Family of Tumors
  • AEWS0331 European Ewing Tumor Working Initiative of National Groups Ewing Tumour Studies 1999 (EURO-E.W.I.N.G.99)
  • AEWS0621A Phase II Trial Modulating EWS/FLI with Cytarabine for Children and Young Adults with Relapsed Ewing Sarcoma
  • AGCT0132 A Phase III Study of Reduced Therapy in the Treatment of Children with Low and Intermediate Risk Extracranial Germ Cell Tumors
  • AREN03B2 Renal Tumors Classification, Biology, and Banking Study
  • ARET0332  A Study of Unilateral Retinoblastoma With and Without Histopathologic High-Risk Features and the Role of Adjuvant Chemotherapy
  • ARST0321 A Phase II Study of Sulindac and Tamoxifen in Patients with Desmoid Tumors That Are Recurrent or Not Amenable to Standard Therapy
  • ARST0531 Randomized Study of Vincristine, Dactinomycin and Cyclophosphamide (VAC) versus VAC Alternating with Vincristine and Irinotecan (VI) for Patients with Intermediate-Risk Rhabdomyosarcoma (RMS)
  • ABTR01B1 A Children's Oncology Group Protocol for Collecting and Banking Pediatric Research Specimens Including Rare Pediatric Tumors
  • CCG-0923 A Trial of Carboxypeptidase-G2 (CPDG2) for the Management of Patients with Intrathecal Methotrexate Overdose
  • D9902 A COG Soft Tissue Sarcoma Biology and Banking Protocol
Rhabdomyosarcoma Trials
  • ARST1321 Pazopanib Neoadjuvant Trial In Non-Rhabdomyosarcoma Soft Tissue Sarcomas (PAZNTIS): A Phase II/III Randomized Trial of Preoperative Chemoradiation or Preoperative Radiation Plus or Minus Pazopanib (NSC# 737754, IND# 118613)
Wilms Tumor Trials
  • CCG-4941L National Wilms Tumor Late Effects Study
  • AREN03B2 Renal Tumors Classification, Biology, and Banking Study
  • ARET0332 A Study of Unilateral Retinoblastoma With and Without Histopathologic High-Risk Features and the Role of Adjuvant Chemotherapy
  • AEWS07B1 A Children’s Oncology Group Protocol for Collecting and Banking Ewing Sarcoma Specimens
  • ABTR01B1 A Children's Oncology Group Protocol for Collecting and Banking Pediatric Research Specimens Including Rare Pediatric Tumors
  • D9902 A COG Soft Tissue Sarcoma Biology and Banking Protocol
Other Trials
  • GNTM 1Z12 Defibrotide for patients with hepatic veno-occlusive disease (VOD): A treatment IND study (Under CFR 312.34)
  • IRB 5507 Severe Chronic Neutropenia International Registry
  • ASCT0521 Soluble Tumor Necrosis Factor Receptor: Enbrel (Etanercept) for the Treatment of Acute Non-Infectious Pulmonary Dysfunction (Idiopathic Pneumonia Syndrome) Following Allogeneic Stem Cell Transplantation
  • IRB 07-086 Use of Erwinia Asparaginase for Pediatric Patients
  • ALTE07C1 Neuropsychological, Social, Emotional and Behavior Outcomes in Children with Cancer
  • ACCL1131 A Phase III Open-Label Trial of Caspofungin vs. Azole Prophylaxis for Patients at High-Risk for Invasive Fungal Infections (IFI) Following Allogeneic Hematopoietic Cell Transplantation (HCT)
  • ACCRN07 Protocol for the enrollment Official COG Registry, The Childhood Cancer Research Network (CCRN)