Sarcoma Program

Overview

Cleveland Clinic’s Sarcoma Program is a national and international resource for the diagnosis and treatment of adults and children with benign and malignant tumors of the bone and soft tissue.

The multidisciplinary sarcoma clinic is designed to provide you with the medical opinions of sarcoma specialists from different disciplines in a single location.  Sarcoma surgeons, medical oncologists, radiation oncologists, radiologists and pathologists come together to review patients with malignant and benign bone and soft tissue tumors. These sarcoma specialists are experienced in the care of complex, challenging tumors. Together, they will come up with the treatment plan most likely to result in the best possible outcome and quality of life.  Our team of pediatric solid tumor specialists also work together to treat children, adolescents, and young adults with rare and common varieties of cancer that occur in young people.

People who develop cancer of the bone or surrounding soft tissue can take comfort in Cleveland Clinic's expertise with musculoskeletal cancers. Although bone tumors are relatively rare, our specialists treat hundreds of people with benign and malignant tumors each year in one of the largest programs in the United States.

In the past, bone cancer often led to amputation. Today, our bone cancer specialists have reversed that trend with limb-sparing surgery at Cleveland Clinic. More than 90 percent of our patients with bone cancer can avoid amputation with only a small chance of recurrence.

Cleveland Clinic is recognized in the U.S. and throughout the world for its expertise and care.

What We Treat

Malignant Tumors

• Angiosarcoma.
• Chondrosarcoma.
• Chordoma.
• Clear Cell Sarcoma.
• Desmoplastic Small Round Cell Tumor.
• Epithelioid sarcoma.
• Ewing's Sarcoma.
• Fibrosarcoma.
• Gastrointestinal Stromal Sarcoma (GIST).
• Giant Cell Tumors.
• Hemangioendothelioma.
• Leiomyosarcoma.
• Liposarcoma.
• Malignant Bone.
• Malignant Soft Tissue Tumors.
• Malignant peripheral nerve sheath tumors.
• Metastatic Bone Tumors.
• Osteosarcoma.
• Rhabdomyosarcoma.
• Soft tissue sarcoma (adult).
• Soft tissue sarcoma (childhood).
• Solitary Fibrous Tumor.
• Synovial Sarcoma.
• Undifferentiated Pleomorphic Sarcoma (previously called malignant fibrous histiocytoma).

Benign Bone Tumors

• Benign Bone Tumors.
• Blood Cell Tumors.
  • Osteosclerotic Myeloma.
  • Solitary Bone Plasmacytoma.
• Cartilage Tumors.
  • Chondroblastoma.
  • Chondromyxoid Fibroma.
  • Multiple Enchondromatosis (Ollier's Disease, Maffucci's Syndrome).
  • Multiple Hereditary Exostosis.
  • Periosteal Chondroma.
  • Solitary Enchondroma.
  • Solitary Osteochondroma.
• Conditions Which Can Be Mistaken For Tumors.
• Fibrogenic & Histiocytic Tumors.
  • Desmoplastic Fibroma.
  • Histiocytoma/Benign Fibrous Histiocytoma.
  • Multiple non-ossifying fibromas (Jaffe-Campanacci Syndrome, Familial Multifocal NOF).
  • Solitary non-ossifying fibroma.
• Giant Cell Tumor (also known as Osteoclastoma).
• Osseous Tumors.
  • Osteoblastoma.
  • Osteoid Osteoma.
• Reactive Lesions.
  • Aneurysmal Bone Cyst.
  • Unicameral Bone Cyst.
• Tumor-like Lesions.
  • Bone Infarct.
  • Bone Island (also known as Enostosis).
  • Brown Tumor of Hyperparathyroidism.
  • Eosinophilic Granuloma.
  • Fibrodysplasia Ossificans Progressiva (Munchmeyer's Disease).
  • Fibrous Dysplasia (McCune Albright Syndrome, Mazabraud Syndrome, Osteofibrous Dysplasia).
  • Focal Fibrocartilaginous Dysplasia.
  • Heterotopic Ossification.
  • Myositis Ossificans.
  • Melorheostosis.
  • Osteofibrous Dysplasia (also known as Ossifying Fibroma, Campanacci Lesion).
  • Paget's Disease.
  • Synovial Osteochondromatosis.
  • Tumoral Calcinosis.
• Vascular Tumors.
  • Hemangioma of Bone.

Benign Soft Tissue Tumors

• Benign Soft Tissue Tumors.
• Fatty Tumors.
  • Angiolipoma.
  • Hibernoma.
  • Intramuscular Lipoma.
  • Pleomorphic Lipoma.
  • Spindle Cell Lipoma.
• Fibrogenic Tumors.
  • Calcifying Aponeurotic Fibroma.
  • Extra-abdominal Desmoid Tumor (Familial Adenomatous Polyposis, Gardner Syndrome).
  • Nodular Fasciitis.
  • Plantar Fibromatosis (Ledderhose Disease).
• Muscular Tumors.
  • Intramuscular Myxoma (Mazabraud's Syndrome).
• Peripheral Nerve Tumors.
  • Neurilemmoma (also known as Schwannoma).
  • Neurofibromatosis.
  • Neuroma (including Morton's Neuroma).
  • Sporadic Neurofibromas.
• Synovial Tumors.
  • Giant Cell Tumor of Tendon Sheath.
  • Pigmented Villonodular Synovitis.
  • Synovial Chondromatosis.
• Vascular Tumors.
  • Glomus Tumor (also known as Paraganglioma).
  • Intramuscular Hemangioma.

Treatment Options

• Chemotherapy.
• Limb salvage.
• Radiation therapy.
• Tumor surgery.

For Additional Information

• Access our free sarcoma treatment guide.
• Visit Health Essentials.
• Search a database of all cancer education topics.

Our Doctors

Medical Oncology

• G. Thomas Budd, MD
• Dale Shepard, MD, PhD
• Joseph Wooley, MD
• Chebli Mrad, MD
• Timmy Nguyen, MD
• Candice Schwartz, MD
• Gary Schwartz, MD

Orthopaedic Oncology

• Nathan Mesko, MD
• Lukas Nystrom, MD
• Timothy Marks, MD
• Jorge Manrique-Succar, MD
• Zachary D. Burke, MD
• Kristi Mareth, PA-C
• Casandra McFrederick, PA-C
• Jason Weisstein, MD

Pediatric Hematology Oncology

• Peter Anderson, MD
• Stefanie Thomas, MD
• Matteo Trucco, MD
• Stacey Zahler, DO

Pathology

• Steven Billings, MD
• Josephine Dermawan, MD, PhD
• Karen Fritchie, MD
• John Goldblum, MD
• Scott Kilpatrick, MD
• John Reith, MD
• Brian Rubin, MD

Psychology & Social Work

• Taylor Buss, LISW
• Julie Dimitrov, LISW
• Nancy Tamburro, LISW
• Melissa Walt, PsyD

Radiation Oncology

• Shauna Campbell, DO
• Erin Murphy, MD
• Jacob Scott, MD, Dphil
• Chirag Shah, MD
• Christopher Fleming, MD
• John Greskovich, Jr, MD
• Mihir Naik, DO
• Jean-Pierre Obeid, MD
• Eva Suarez, MD

Radiology

• Michael Forney, MD
• Amer Hanano, MD
• Hakan Ilaslan, MD, MBA
• Claus Simpfendorfer, MD
• Carl Winalski, MD
• Fangbai Wu, MD

General Surgery

• Daniel Joyce, MBBCh
• Samer Naffouje, MD
• Robert Simon, MD
• Anthony Visioni, MD
• Matthew Walsh, MD

Pediatric General Surgery

• David Magnuson, MD

Thoracic Surgery

• Sudish Murthy, MD, PhD
• Daniel Raymond, MD

Spine Surgery

• Ajit Krishnaney, MD

Ear, Nose & Throat Surgery

• Jamie Ku, MD
• Eric Lamare, MD
• Brandon Prendes, MD

Plastic Surgery

• Graham Schwarz, MD
• Eliana Ferreira Ribeiro Duraes, MD
• Andres Mascaro Pankova, MD
• Martin Newman, MD
• Arvind Padubidri, MD

Intercranial Neurosurgery

• Varun Kshettry, MD
• Pablo Recinos, MD

Urology

• Venkatesh Krishnamurthi, MD

Gynecologic Oncology

• Mariam Alhilli, MD
• Lindsey Beffa, MD
• Robert DeBernardo, MD
• Michelle Kuznicki, MD
• Chad Michener, MD
• Lisa Rauh-Benoit, MD
• Anthony Rizzo, MD
• Peter Rose, MD
• Roberto Vargas, MD
• Steven Waggoner, MD

Support & Services

Patient Services

In addition to offering state of the art diagnostic techniques and sarcoma treatment methods, our sarcoma specialists offer an array of resources that can help patients cope with the demands of cancer. Patients are encouraged to take advantage of these resources to ease the burden of managing cancer.

• View more Patient Education and Support resources

Additional Patient Resources

• National Comprehensive Cancer Network (NCCN) Soft Tissue Sarcoma Patient Guidelines
• National Comprehensive Cancer Network (NCCN) Bone Sarcomas Patient Guidelines

The Race to Cure Sarcoma helps raise both awareness and resources for sarcoma research nationally through the Sarcoma Foundation of America and locally through Cleveland Clinic. To learn more, watch this video and visit this web site for more information on this year's race.

Patient Testimonials

• Young Girl is Cancer Free After Year-Long Battle with Ewing's Sarcoma
• Second Opinion Keeps Cancer Fighter Enjoying The Outdoors
• Survivor Connects With Others Through Humor and Positivity
• Husband Fighting Rare Cancer After Wife Persisted He Seek Second Opinion

Related Content

• View articles written by our Sarcoma Program team

Clinical Trials & Research

Cleveland Clinic Cancer Center clinical trials offer patients important sarcoma treatment options and access to the latest treatments and procedures resulting from cancer research.

• Learn more about our Research & Innovations

Clinical Trials

Clinical trials (or research studies) help us create the medicine of tomorrow. They provide hope through offering testing of new drugs, new surgical techniques or other treatments before they are widely available.

We can help you access hundreds of clinical trials across all specialty areas. Our new searchable online trials tool makes identifying treatment opportunities easier than ever.

Medical Professionals

Cleveland Clinic Cancer Center is committed to working with you to provide the best care for your patients. Our team is also dedicated to the training and education of medical professionals to advance cancer care and research.

• View our For Medical Professionals resources.

Pathology Second Opinion

Cleveland Clinic Laboratories offers second opinion pathology consultations for surgical pathology, cytology, and hematopathology cases.

• Request a consultation.

Referrals

Make An Online Referral to Cleveland Clinic Cancer Center

To make a direct online referral to Cleveland Clinic Cancer Center, complete our Online Cancer Patient Referral Form or visit clevelandclinic.org/cancerpatientreferrals.

You will receive confirmation once the appointment is scheduled.

Surgical Referrals

To refer a surgical patient, please contact our Referring Physician Hotline, available every day from 7 a.m. to 7 p.m. EST, for all your needs, by calling 855.REFER.123 (855.733.3712).

National Ewing Sarcoma Tumor Board

Cleveland Clinic and Cleveland Clinic Children’s are hosting an educational National Ewing Sarcoma Tumor Board in collaboration with sarcoma experts across the nation.

Our mission is to provide expertise and education in the treatment and management of challenging or complex Ewing Sarcoma Family Tumors. Experts share their knowledge and discuss clinical trials and innovative treatments to help enhance the quality of life for the Ewing Sarcoma patients.

Virtual meetings take place the second Monday of each month at 5 p.m. (EST).

Physicians are invited to participate and submit de-identified cases. Patients and families are not permitted to attend.

Physicians can request an invite to participate by contacting our tumor board coordinator at keaneyh@ccf.org

Physicians can submit cases at clevelandclinic.org/NEWSBoard.

Disclaimer: The National Ewing Sarcoma Tumor Board and its discussions are for educational purposes only. The discussions during the sessions do not represent a second opinion or a formal pathologic, radiographic, surgical or medical review. Each physician presenting on behalf of their patient is solely responsible for their patient’s plan of care.

To request an official pathology second opinion consultation from Cleveland Clinic, please contact your health care provider or visit our web site.

In collaboration with the Carson Sarcoma Foundation, Chemo Warrior Foundation and Allen B. Slifka Foundation.

Cancer Advances Podcast

A Cleveland Clinic podcast for medical professionals exploring the latest innovative research and clinical advances in the field of oncology. Listen to Cancer Advances. 

Featured Sarcoma Episodes:

• Surgical Insight: Limb Sparing Techniques for Pediatric Sarcoma Patients.
• Challenges and Opportunities in Pediatric Sarcoma Care.
• Managing Sarcoma.

Consult QD | Cancer

Our cancer care blog for physicians and healthcare professionals. Discover emerging advances, innovations, and research insights from Cleveland Clinic Cancer Care specialists. Explore Consult QD.

Appointments & Locations

Call the Cancer Answer Line in Ohio at 866.223.8100 for:

• Answers to your questions about cancer.
• Personalized assistance in making appointments and accessing patient services.

The Cancer Answer Line is available Monday through Friday from 8 a.m. – 4:30 p.m. (Eastern time).

The Cancer Answer Line is staffed by oncology nurse specialists who will assist you in scheduling appointments for consultation with a physician, including obtaining tests or results that you may need for your visit.

The Cancer Answer Line can also provide answers to your questions about cancer and Cleveland Clinic Cancer Center.

• Ohio Pediatric Sarcoma - 216.444.5517
• Florida Sarcoma: 877.463.2010

Locations

We work as one team — providing expert care at convenient locations throughout Northeast Ohio and Florida. Depending on the severity of your sarcoma, you may be able to see a provider close to home or you may need to come to our main campus for more complex care.

Cleveland Clinic Main Campus Fairview Hospital Hillcrest Hospital M Building - Cleveland Clinic Children's CA Building - Taussig Cancer Center Akron General Akron General Medical Outpatient Center Akron General Obstetrics and Gynecology, Green Wadsworth Express and Outpatient Care Indian River Hospital Scully-Welsh Cancer Center Tradition HealthPark One Martin North Hospital Weston Hospital