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Research Labs

Ophthalmic Research

Cleveland Clinic Cole Eye Institute Department of Ophthalmic Research is chaired by Joe G. Hollyfield, PhD, and has a strong commitment to improving our understanding of the molecular and cellular basis of vision loss and the exploitation of this knowledge for the development of targeted therapeutics. The faculty in the department is involved in multi-disciplinary and highly collaborative approaches using both basic science and clinical investigation, which serves as a basis for exploring and evaluating treatment strategies to slow and prevent vision loss. Disorders currently being investigated include retinitis pigmentosa, macular degeneration (juvenile and age-related forms), diabetic retinopathy, retinopathy of prematurity, vision restoration, ciliopathies, glaucoma, corneal disorders such as transplantation, and wound healing and repair.

Read more

Visit the Cleveland Clinic Lerner Research Institute

View Research and Publications by Dr. Hollyfield

Cole Eye Institute Research Labs

Angiogenesis

Director: Bela Anand-Apte, MBBS, PhD
Cole Eye Institute
Cleveland Clinic
Office: 216.445.9739
Lab: 216.445.1992
Email:anandab@ccf.org

Research and Publications



Laboratory Goals

  • Understanding the basic molecular mechanisms of angiogenesis with a special focus on Tissue Inhibitors of Metalloproteinases (TIMPs)
  • Examination of the physiological and pathological pathways that regulate retinal vascular leakage

Download full lab details and projects. 

Corneal Wound Healing, Diseases & Ocular Surface

Director: Steven E. Wilson, MD
Cleveland Clinic
Office: 216.444.5887
Lab: 216.444.3871
Email: wilsons4@ccf.org

Research and Publications

Laboratory Goals
Identify and characterize the growth factor-receptor systems through which the functions of corneal, immune, and other cells of the anterior segment of the eye are controlled during development, homeostasis, and wound healing; Understand at the molecular and cellular level, the factors that lead to corneal opacity, and its resolution, after injury, surgery or infection; Explore the mechanism of epithelial basement membrane regeneration after injury and the importance of the corneal epithelial basement membrane in modulating epithelial-stromal interactions in the cornea, including development of myofibroblasts associated with corneal stromal opacity.

Download full lab details and projects.

Diagnostic Imaging and Biophotonics Laboratory

Director: Yuankai Tao, PhD
Cole Eye Institute
Cleveland Clinic
Office: 216.445.3867
Email:taoy@ccf.org


Research and Publications



Research Projects

  • Intraoperative Guidance Using Microscope-integrated Optical Coherence Tomography (Mi-OCT)
  • Contrast-Free Functional Imaging

Download full lab and project description.

Regeneration/Cell Therapy

Alex Yuan MD

Director: Alex Yuan, MD, PhD
Cole Eye Institute
Cleveland Clinic
Office: 216.444.0079
Email: yuana@ccf.org

Research and Publications

Laboratory Goals
Characterize the wound healing response of the retina and develop novel methods to repair damaged retina.

Download full lab description.

Innate Immunity

Director: K. P. Connie Tam, PhD
Cole Eye Institute
Cleveland Clinic
Office: 216.445.7936
Laboratory: 216.445.7519
Email: tamk@ccf.org

Research and Publications

Laboratory Goals
Study of the epithelial innate defense system, and how dysregulation of these defense mechanisms can lead to diseases.

Download full lab details and projects

Neurovascular Development

Sujata Rao

Director: Sujata Rao PhD
Cole Eye Institute
Cleveland Clinic
Office: 216.636.3156
Fax: 216.445.3670
Email: raos7@ccf.org

Research and Publications

Laboratory Goals

To understand how neurons and vasculature pattern themselves and interact with each other during development, as well as in disease.

Download full lab details, projects and research.

Visual Electrophysiology

Director: Neal S. Peachey, PhD
Cole Eye Institute
Cleveland Clinic
Office: 216.445.1942
Lab: 216.445.1941
Email: peachen@ccf.org

Research and Publications

Laboratory Projects

  • Congenital Stationary Night Blindness
  • Non-neuronal Cells Support of Retinal Function 

Download full lab details, goals and projects. 


Proteomics

Director: John W. Crabb, PhD
Cole Eye Institute
Cleveland Clinic
Office: 216.445.0425
Laboratory: 216.445-0424
Email: crabbj@ccf.org
www.lerner.ccf.org/eye/crabb/

Research and Publications

Laboratory Projects

  • Age-related macular degeneration
  • Glaucoma

Download full lab details, goals and projects.

Genetics

Director: Stephanie A. Hagstrom, PhD
Cole Eye Institute
Cleveland Clinic
Office: 216.445.4133
Laboratory: 216.444.5663
Email: hagstrs@ccf.org

Research and Publications

Projects

  • The function of TULP1 in photoreceptor cells of the retina
  • Pharmacogenetics of neovascular age-related macular degeneration
  • Genetic analysis of inherited retinal diseases

Download full lab details.

Retinal Cell Biology

Director: Brian D. Perkins, PhD
Cole Eye Institute
Cleveland Clinic
Office: 216.444.9683
Fax: 216.445.3670
Email: perkinb2@ccf.org

Research and Publications

Laboratory Goals

Develop zebrafish models that mimic photoreceptor degeneration in childhood diseases like Joubert Syndrome, Bardet-Biedl Syndrome, and Usher Syndrome.

Download full lab details and projects. 

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To find a Cole Eye Institute specialist for your needs, contact us at 216.444.2020 (or toll-free 800.223.2273, ext. 42020)

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To arrange a same-day visit, call 216.444.CARE (2273)

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