In addition to their research and training activities, physicians in the Center for Reproductive Medicine have a very active clinical practice in male and female infertility. They offer the latest medical and surgical options for the treatment of a couple with infertility including the full range of assisted reproductive techniques. Patients benefit from its integrated, evidence-based approach to treatment, and our success rate in achieving pregnancy is consistently amongst the highest in the United States.
Fertility Testing Services
For the past 30 years, our state-of-the-art Fertility Testing Laboratory has been providing the highest quality services to couples being evaluated for their infertility. Our laboratory features state-of-the-art testing using the latest, most effective diagnostic testing and analysis. Our laboratory is certified by CLIA in the state of Ohio, accredited since 1994 by the College of American Pathologists (CAP) "Reproductive Laboratory Program."
The laboratory also offers fertility preservation services to cancer patients such as:
- Therapeutic semen banking
- Ovarian cryopreservation (Patient information)
- Home Sperm Banking – NextGenSM kit options for collecting semen samples at home and convenient overnight delivery.
Our gamete bank is accredited by the American Association of Tissue Banks (AATB) since 1999 and registered with FDA since 2006. Our laboratory has assisted thousands of patients over the years and is recognized not only for the excellent quality of our work but also for our highly qualified, experienced and compassionate staff.
Advanced tests for semen analysis
Research conducted in the Center has been standardized, published and is offered as clinical tests for the patients. Some of these include the acrosome test, and semen profile test. A semen profile includes measurement of reactive oxygen species, total antioxidant concentration and the extent of DNA damage in the sperm. Together theses tests can provide valuable information for the physician.
The center has developed a novel kit for home sperm banking for patients who prefer to collect the sample at home and ship it to the lab for further processing. This kit is called the Home sperm Collection kit or the NextGenTM kit. Banking.
Oxidative stress and male infertility
Research in oxidative stress (OS) and male infertility remains the hallmark of our center. The center is recognized nationally and globally for identifying oxidative stress as a major pathology of male infertility. Studies are designed at understanding the underlying mechanism(s) of OS into the various causes of male infertility.
Proteomics and male infertility
To further gain insight into the cellular and biological processes involved in oxidative stress induced male infertility; we are exploring mechanisms utilizing proteomic tools and genetic ontology enrichment analysis. Current projects are examining the alterations in the proteome in oxidative stress induced male infertility cases and also examining the mechanism of varicocele and male infertility.
Cell phone and male infertility
We have demonstrated the negative affects of cell phone and sperm quality. Animal models are lacking that can serve as an alternate model to humans to explain the nature of radiofrequency waves produced by cell phones in the talk mode and how they may affect sperm quality. Utilizing sheep as a unique model we are currently examining the changes in the testis, epididymis and in the spermatozoa to understand the underlying mechanism following exposure to radiofrequency waves.
Dynamics of sperm cryopreservation utilizing home sperm banking kit
We are examining a possible alternative for patients wanting to preserve their future fertility, but do not have access to a fertility clinic.
We have developed a novel home sperm banking kit called NextGen that allows patients to ship their samples conveniently. This system is of particular value for 1) men with cancer or underlying subfertility, 2) pre-vasectomy patients who may want to cryopreserve in advance of their vasectomy, 3) men with a desire to insure potential future fertility 4) Military personnel going on deployment in war.
Our pilot data has shown that the NextGen kit provides a safe, reliable and convenient method for men to ship their samples to Cleveland Clinic from any part of the United States. In the ongoing study, the goal is to compare sperm quality and the extent of DNA damage in samples collected onsite versus those collected offsite and shipped via the NextGen kit.
This is a valuable, cost-effective alternative, especially for cancer patients who are instructed to bank multiple specimens in a short period of time in order to have adequate numbers of sperm that can be used for procreation by assisted reproductive techniques. These patients sometimes travel great distance (other cities or neighboring states) to find a sperm bank, take time off from work and incur significant travel expenses. Maintaining DNA integrity is critical for procreation which is being validated in these studies.
The Center is known worldwide for conducting and publishing groundbreaking research with significant implications for disorders such as infertility and erectile dysfunction.
- More than 1,500 published papers.
- More than two dozen basic science and clinical research projects currently in progress.
- More than 100 papers published in peer-reviewed journals since January 2010.
- More than 100 presentations at leading national and international medical and scientific conferences since January 2010.
- Published over two dozen medical text books.
Research and Training Opportunities
Our research fellowship and training opportunities in Semenology and Assisted Reproductive Techniques represent one of the largest and most comprehensive academic programs of its kind in the United States. Through a one-on-one training experience with our professional staff, fellows and trainees develop technical expertise in all of the essential laboratory techniques. Opportunities for cutting edge research in male infertility are available to basic scientists and clinical investigators.
Summer Internship Program
The center has hosted the now popular summer internship program which is a unique, well structured and highly integrated research internship for pre-med and medical students.
The eight-week long highly sought after program helps introduce the fundamentals of clinical research to the interns and provides rigorous training and ample opportunities for scientific education, research and writing.
Interns receive personal coaching by a team of mentors to write and publish high quality scientific articles in high impact journals. What distinguishes this program from any other internship is the fact that all interns who are selected in our program are trained in scientific research and writing and earn an authorship on scientific articles which are then published. These features makes this program the most unique of its kind in the whole world.
The program encourages students to consider a career in medicine, provides a wide range of high quality research experiences, allows participation in research programs in real laboratory setting and facilitates close interaction with Reproductive Endocrinologists, Gynecologists, Urologists and Male Infertility specialists. Each year 20-25 interns are selected for this prestigious internship. In the last five years, over 100 students have graduated from our summer internship course.
The high productivity of the program is reflected by the cutting edge research published at scientific meetings and leading journals in reproductive medicine.
Recipient of 2011 Innovator Award for the development of "Remote Sperm Banking Kits" from the Cleveland Clinic.
- Innovations Scholarship in Teaching (SIT) Award Case Western University School of Medicine for excellent teaching and mentoring by the Center’s faculty.
Center for Reproductive Medicine, Desk A19
Glickman Urological and Kidney Institute
9500 Euclid Ave.
Cleveland, OH 44195