Renal Diseases

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The mission of the Center for Renal Diseases is to diagnose and prevent kidney disease, anticipate complications, and treat renal problems before they become life threatening. The center is staffed with experienced nephrologists and other healthcare professionals who develop and implement customized treatment for polycystic kidney disease (PKD), kidney stones, glomerulonephritis (GN), and the Anemia Clinic.


Cleveland Clinic is a leader in research to uncover innovative ways of managing PKD with the goal of establishing an evidence-based medical approach to the diagnosis and treatment of the disease.


The Department of Nephrology is a participant in the first national randomized clinical trial of treatments for PKD. The HALT-PKD study involves individuals with autosomal dominant polycystic kidney disease (ADPKD), the most common inherited form of PKD. Participants are given drugs to control hypertension. The study will use kidney growth to measure the effectiveness of an intervention.

This study is important because hypertension complications, including stroke and heart attack, affect many more individuals with ADPKD than with ADPKD-specific conditions, such as liver cysts or brain aneurysms. The goal of this study is to discover methods to slow the progression of ADPKD and related health conditions.

Cleveland Clinic Pilot Study

In addition to the HALT-PKD Trial, a pilot study is under way at Cleveland Clinic to examine the effects of sirolimus in reducing renal cysts and kidney volume in ADPKD patients. Traditionally, sirolimus is an immunosuppressant used in combination with cyclosporine and a steroid medication to prevent the body from rejecting a kidney transplant. The Center for Renal Diseases is at the forefront of research and testing of medications that could change the way PKD is treated in the future.

Call us for an Appointment

Urology Appointments: 800.223.2273 ext. 4-5600
Nephrology Appointments: 800.223.2273 ext. 4-6771

This information is provided by Cleveland Clinic and is not intended to replace the medical advice of your doctor or health care provider. Please consult your health care provider for advice about a specific medical condition.

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