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George Muschler, MD

216.444.2606

George Muschler, MD
Department: Orthopaedic Surgery
Vice Chair, Orthopaedic and Rheumatologic Institute
Location: Cleveland Clinic Main Campus
Mail Code A41
9500 Euclid Avenue
Cleveland, OH 44195
WorkAppointment:216.444.2606
DeskDesk:216.444.5338
WorkFax:216.445.6255
George Muschler, MD
Department: Taussig Cancer Institute
Location: Cleveland Clinic Main Campus
Mail Code A41
9500 Euclid Avenue
Cleveland, OH 44195
WorkAppointment:216.444.2606
DeskDesk:216.444.5338
WorkFax:216.445.6255
George Muschler, MD
Department: Transplantation Center
Location: Cleveland Clinic Main Campus
Mail Code A41
9500 Euclid Avenue
Cleveland, OH 44195
WorkAppointment:216.444.2606
DeskDesk:216.444.5338
WorkFax:216.445.6255
George Muschler, MD
Department: Biomedical Engineering
Location: Cleveland Clinic Main Campus
Mail Code A41
9500 Euclid Avenue
Cleveland, OH 44195
WorkAppointment:216.444.5338
DeskDesk:216.444.5338
WorkFax:216.445.6255
Surgeon:
Yes
Treats:
Adults Only

Biographical Sketch

George Muschler, MD, joined the Department of Orthopaedic Surgery in 1988. Since his arrival, he has developed a regional and national reputation in reconstructive surgery for arthritis, failed joint replacements, treatment of fractures that have failed to heal and treatment of limb deformities. He is recognized and appreciated internationally as a leader in skeletal reconstruction, bone regeneration and fracture repair. In 1999, he was appointed Research Associate in the Cleveland Clinic Office of Clinical Effectiveness, due to his work in establishing a program of patient-oriented outcomes assessment for hip and knee replacements performed in the Department of Orthopaedic Surgery. Dr. Muschler is also a member of Cleveland Clinic Taussig Cancer Center, leading and collaborating in research related to aging and adult stem cell therapies and transplantation.

In addition to his commitment to patient care, Dr. Muschler is a Vice-Chairman of the Department of Biomedical Engineering within the Cleveland Clinic's Lerner Research Institute. There he directs the Bone Biology Laboratory. This laboratory is supported by the National Institutes of Health and other funding agencies, and is focused on development of improved methods for tissue engineering and regenerative medicine. This work has provided insight into the effects of aging on stem cells of bone and cartilage, and the importance and application of these cells in development of osteoporosis, bone diseases and in the broader area of tissue repair, including bone, cartilage, tendon, nerve, muscle and skin.

Dr. Muschler has become a leader in the development of collaborative interdisciplinary programs and research teams in the area of tissue engineering and regenerative medicine, contributing significantly to both regional and national development of translational research leading to new products and therapeutic strategies. In 2005, he and colleagues at Cleveland Clinic, Case Western Reserve University, University Hospitals, NASA Glenn Research Center and the Ohio Super Computer Center established the Clinical Tissue Engineering Center (CTEC), through a grant from the Ohio Third Frontier Program. CTEC continues to serve as a catalyst for research and collaboration in the development and assessment of new therapies between over 70 Ohio investigators and over 10 Ohio institutions.

Dr. Muschler and CTEC participate in the National Center for Regenerative Medicine (NCRM), a collaboration between Cleveland Clinic and Case Western Reserve University, where he serves in the Executive Committee.

Since 2007, Dr. Muschler has served as Vice Chairman of the Orthopaedic and Rheumatologic Institute at the Cleveland Clinic, focusing efforts in the area of Research and Clinical Quality Assessment and Management.

In 2007, Dr. Muschler became Co-Director of the Armed Forces Institute for Regenerative Medicine (AFIRM), which is now an integrated national network of leading scientists and clinicians at 28 other institutions dedicated to developing new methods for treating battlefield injuries sustained by US service members.

Professional Highlights

  • Director, Orthopaedic and Rheumatologic Research Center, 2005-Present
  • Director, Clinical Tissue Engineering Center (CTEC), 2005-Present
  • Vice Chairman, Department of Biomedical Engineering, 2004-Present
  • Vice Chairman for Research, Cleveland Clinic Orthopaedic and Rheumatologic Institute, 2007-Present
  • Co-Director, Armed Forces Institute for Regenerative Medicine (AFIRM), 2007-Present

Education & Fellowships

Fellowship - Weill Cornell Medical, Hospital for Special Surgery
Orthopaedic Surgery
New York, NY USA
1988
Fellowship - Memorial Sloan-Kettering Cancer Center
Musculoskeletal Oncology
New York, NY USA
1988
Residency - University of Texas Southwestern Medical Center at Dallas
Orthopedic Surgery
Dallas, TX USA
1986
Internship - University of Texas Southwestern Medical Center at Dallas
Surgical Internship
Dallas, TX USA
1982
Medical School - Northwestern University Feinberg School of Medicine
Chicago, IL USA
1981
Undergraduate - University of Illinois Hospital at Urbana-Champaign
Chemistry
Urbana, IL USA
1977

Certifications

  • Orthopaedic Surgery

Specialty Interests

Joint replacement surgery, treatment of fracture non-unions and avascular necrosis, research in regenerative tissue engineering, adult stem cell biology, health care quality assessment

Awards & Honors

  • North American Traveling Fellowship, American Orthopaedic Association, 1989
  • Career Development Award, Orthopaedic Research and Education Foundation, 1990-1992
  • J.P Ranney Award for Innovation in Regenerative Medicine and Stem Cell Research, 2006
  • Clevelands Best Doctors, Northern Ohio Live magazine, 2007

Innovations & Patents

  • Innovator in both implant design for joint surgery and limb reconstruction, as well as in the application of biological principles to the regeneration of new tissues, particularly bone.  
  • Responsible for over nine patents and recognized as inventor of the concept of selective retention as a means of rapidly concentrating and delivering a patient's own stem cells for use in tissue-healing applications. This is the basis for the Cellect TM Device, that has now been used in treatment of over 50,000 patients worldwide for bone repair following spine surgery or fractures.  

Memberships

  • American Academy of Orthopaedic Surgeons
  • Orthopaedic Research Society
  • American Orthopaedic Association
  • Association of Bone and Joint Surgeons
  • International Society for Tissue Engineering
  • International Society for Stem Cell Research
  • American Society for Bone and Mineral Research

Treatment & Services

  • Arthritic Knee Conditions
  • Arthritis Surgery
  • Arthroplasty
  • Complex Primary Hip Arthroplasty
  • Complex Primary Knee Arthroplasty
  • Fracture Non-union
  • Hip & Knee Surgery
  • Hip Replacement
  • Hip Revision
  • Joint Preserving Hip Surgery
  • Joint Reconstruction
  • Joint Replacement
  • Joint Replacement Of The Knee
  • Knee Arthroplasty
  • Knee Revision
  • Minimally Invasive Hip Joint Replacement
  • Minimally Invasive Knee Joint Replacement
  • Minimally Invasive Surgery
  • Orthopaedic Surgery
  • Primary And Revision Joint Replacements
  • Primary And Revision Total Hip Arthroplasty
  • Primary And Revision Total Knee Arthroplasty
  • Reconstructive Surgery Of The Hip
  • Reconstructive Surgery Of The Knee
  • Revision Hip Arthroplasty
  • Revision Hip Joint Replacement
  • Revision Joint Replacement
  • Revision Knee Arthroplasty
  • Revision Knee Joint Replacement
  • Revision Total Hip Replacement
  • Revision Total Knee Replacement
  • Surgery
  • Surgical Treatment Of Arthritis Of The Hips And Knees
  • Total Knee Replacement

Specialty in Diseases and Conditions

  • Arthritic Knee Problems
  • Arthritis
  • Arthritis Of The Hip
  • Arthritis Of The Knee
  • Avascular Necrosis Of The Hip
  • Avascular Necrosis Of The Knee
  • Hip Replacement
  • Knee Injuries
  • Knee Pain
  • Osteoarthritis Of The Hips And Knees In The Elderly

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. The Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, the Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 6/28/2014, Dr. Muschler has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by the Cleveland Clinic. To learn more about the Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers’ discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Languages Spoken

  • English