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Gene Barnett, MD, MBA


Gene Barnett, MD, MBA
Department: Brain Tumor and Neuro-Oncology Center
Director, Burkhardt Brain Tumor and Neuro-Oncology Center and Director, Cleveland Clinic Gamma Knife Center
Location: Cleveland Clinic Main Campus
Mail Code S73
9500 Euclid Avenue
Cleveland, OH 44195
Gene Barnett, MD, MBA
Department: Taussig Cancer Institute
Location: Cleveland Clinic Main Campus
Mail Code S73 - Clinic R20
9500 Euclid Avenue
Cleveland, OH 44195
Type of Doctor:
Adults Only

Biographical Sketch

Gene H. Barnett, MD, is Director of Cleveland Clinic’s Brain Tumor and Neuro-Oncology Center; Director of the Cleveland Clinic Health System Gamma Knife Center; and Vice-Chairman of the Department of Neurological Surgery. He has served on the Board of Governors of Cleveland Clinic for a five-year term and was President of the Staff.

He has authored more than 210 articles published in leading medical journals and has a particular interest in the areas of neuro-oncology, computer-assisted surgery and stereotactic radiosurgery. In the late 1980s, Dr. Barnett created the Center for Computer-Assisted Neurosurgery at Cleveland Clinic, which established Cleveland Clinic's neurosurgery program as an innovator in following:

  • Advanced stereotaxis, or the identification of discreet areas of the brain that control specific functions
  • Computer applications resulting in the creation of a powerful surgical navigation system called frameless stereotaxy.

He holds several patents in these areas and continues work on the development of technology in neurosurgery including laser lesioning systems for brain tumors..

Dr. Barnett is a past-president of the Ohio State Neurosurgical Society, and the Northeast Ohio Neurosurgical Society. He was a state representative for the Joint Council of State Neurosurgical Societies, and he has served as Chairman of its Northwest Quadrant. He also has served on the Executive Committee of the Section on Tumors and has been on the Board of Directors of the Joint Section of Stereotactic and Functional Neurosurgery and Board of Directors of the American Association of Neurological Surgeons. In addition, he has served on a number of editorial boards and is a reviewer for several neurosurgery journals.

He received his degree from Case Western Reserve University School of Medicine in Cleveland, completed his residency at the Cleveland Clinic Department of Neurosurgery and his fellowship in Neurosurgery at Massachusetts General Hospital in Boston, where he was a clinical and research fellow at the Harvard Medical School and Massachusetts General Hospital.  He completed his Masters of Business degree at the Weatherhead School of Management of Case Western Reserve University

Professional Highlights

  • Rose Ella Burkhardt Chair in Brain Tumor Research
  • Mahaley Clinical Brain Tumor Research Award
  • EDI Innovations Award

Education & Fellowships

Graduate - Case Western Reserve University Weatherhead School of Management
Cleveland, OH USA
Other - Karolinska Gamma Knife Center
Gamma Knife
Stockholm Sweden
Fellowship - Massachusetts General Hospital
Neurosurgical Surgery
Boston, MA USA
Residency - Cleveland Clinic
Neurological Surgery
Cleveland, OH USA
Internship - Cleveland Clinic
General Surgery
Cleveland, OH USA
Medical School - Case Western Reserve University School of Medicine
Cleveland, OH USA
Undergraduate - Case Western Reserve University
Biology and Chemistry
Cleveland, OH USA


  • Neurological Surgery

Specialty Interests

Brain tumor, gamma knife

Awards & Honors

  • Best Doctors in America
  • Top Docs
  • Mahaley Clinical Brain Tumor Research Award
  • EDI Innovations Award

Innovations & Patents

  • Multiple patents in the field of surgical navigation allowing for better, safer brain tumor surgery
  • Patent involving the use of a blood marker to detect presence or progression of brain tumors

Treatment & Services

  • Balloon Compression for Trigeminal Neuralgia
  • Brain Biopsy
  • Brain Tumor Diagnosis
  • Brain Tumor Management
  • Brain Tumor Surgery
  • Clinical Trials
  • Cranial Radiosurgery
  • Craniotomy for Brain Tumor
  • Gamma Knife Radiosurgery
  • Gamma Knife Treatment
  • High Risk Pregnancy Care
  • Lumbar Puncture (Spinal Tap)
  • Microvascular Decompression
  • Minimally Invasive Surgery
  • Neurosurgery
  • Novalis Radiosurgery/Radiotherapy
  • Radiation Therapy
  • Spinal Radiosurgery
  • Stereotactic Brain Biopsy
  • Stereotactic Radiosurgery
  • Stereotactic Surgery

Specialty in Diseases and Conditions

  • Acoustic Neuroma
  • Adult Brain Tumors
  • Anaplastic Astrocytomas
  • Anaplastic Oligodendrogliomas
  • Astrocytoma
  • Benign Brain Tumors
  • Benign Tumors of the Brain
  • Benign Tumors of the Spinal Cord
  • Brain Cancer (Brain Tumor)
  • Brain Lymphoma
  • Brain Metastases
  • Cavernous Malformation
  • Cavernous Sinus Tumors
  • Chordomas
  • Clival Chordomas
  • Ependymomas
  • Glioblastoma Multiforme
  • Hemangioblastomas
  • Malignant Gliomas
  • Malignant Tumors of the Brain
  • Malignant Tumors of the Spinal Cord
  • Meningioma
  • Metastatic Cancer
  • Oligodendroglioma
  • Pilocytic Astrocytoma
  • Pituitary Tumors
  • Primary Central Nervous System Lymphomas
  • Sarcomas of the Brain or Head
  • Schwannoma
  • Trigeminal Neuralgia
  • Von Hippel-Lindau Disease (VHL)

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 10/11/2016, Dr. Barnett has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Barnett receives fees of $5,000 or more per year as a paid consultant, speaker or member of an advisory committee for the following companies:

  • Monteris Medical, Inc.

Royalty Payments. Dr. Barnett receives or has the right to receive royalty payments for inventions or discoveries commercialized through the companies shown below:

  • Mako Surgical Corp.
  • Roche (Hoffman-La Roche, Ltd.)

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers’ discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Languages Spoken

  • English

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