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Reproductive Medicine

The American Center for Reproductive Medicine at Cleveland Clinic reproductive experts offer comprehensive patient care in infertility. Learn more from our experts.

Learn more about Cleveland Clinic’s nationally top-ranked urology program.

Welcome to the Cleveland Clinic's American Center for Reproductive Medicine, a unique research and training program that also provides clinical services at the Glickman Urological & Kidney Institute.

The Center was established in 1993 with a two-fold mission:

  • To conduct cutting-edge translational research into the causes of human reproductive and sexual disorders, leading to the development of new markers, treatment and clinical cures for infertility.
  • Train physicians and scientists with a commitment to advancing the understanding of human reproduction, fertility, and enhance reproductive outcomes.

The Center's interdisciplinary staff of scientists, practicing andrologists/urologists and reproductive endocrinologists from all over the world is one of the many aspects that sets The American Center for Reproductive Medicine apart.

Clinical Care

In addition to the research and training activities, physicians in The American Center for Reproductive Medicine have a very active clinical practice in male and female infertility. They offer the latest medical and surgical options for the treatment of a couple with infertility including the full range of assisted reproductive techniques. Patients benefit from evidence based care and latest therapeutic approaches, and our success rate in achieving pregnancy at The American Center for Reproductive Medicine is consistently among the highest in the United States.

Fertility Testing Services

For the past 30 years, our state-of-the-art Fertility Testing Laboratory has been providing the highest quality services to couples being evaluated for their infertility. Our laboratory features state-of-the-art testing using the latest, most effective diagnostic testing and analysis. Our laboratory is certified by CLIA in the state of Ohio, accredited since 1994 by the College of American Pathologists (CAP) "Reproductive Laboratory Program."

The laboratory also offers fertility preservation services to cancer patients such as:

  • Therapeutic semen banking
  • Ovarian cryopreservation (Patient information)
  • Home Sperm Banking NextGenTM kit options for collecting semen samples at home and convenient overnight delivery.

Our sperm bank has been registered with FDA since 2006. Our laboratory has assisted thousands of patients over the years and is recognized not only for the excellent quality of our work but also for our highly qualified, experienced and compassionate staff.

Advanced tests for semen analysis

Research conducted in the Center has been standardized, published and is offered as clinical tests for the patients. Some of these include our latest oxidation reduction potential or (ORP) test, and semen profile test. A semen profile includes measurement of reactive oxygen species, total antioxidant concentration and the extent of DNA fragementation. Together these tests can provide valuable information for the physician.

For more information, view treatment guides from the Glickman Urological and Kidney Institute.

Research and Innovation

The center has developed a novel kit for home sperm banking for patients who prefer to collect the sample at home and ship it to the lab for further processing. This kit is called the Home sperm Collection kit or the NextGen ® kit. Banking.

Oxidative stress and male infertility

Research in oxidative stress (OS) and male infertility remains the hallmark of our center. The center is recognized nationally and globally for identifying oxidative stress as a major pathology associated with male infertility. Studies are designed at understanding the underlying mechanism(s) of OS into the various causes of male infertility.

Proteomics and male infertility

To further gain insight into the cellular and biological processes involved in oxidative stress induced male infertility; we are exploring mechanisms utilizing proteomic tools and gene ontology annotations and proprietary software packages to identify the differentially affected processes, pathways, cellular distribution, and protein-protein interactions. Current projects are examining the alterations in the both spermatozoa and seminal plasma proteome in oxidative stress induced male infertility cases and also define oxidative stress induced proteome changes in varicocoele and unexplained male infertility.

Dynamics of sperm cryopreservation utilizing home sperm banking kit

We have developed a novel home sperm banking kit called NextGen ® that allows patients to ship their samples conveniently. This system is of particular value for 1) men with cancer or underlying subfertility, 2) pre-vasectomy patients who may want to cryopreserve in advance of their vasectomy, 3) men with a desire to insure potential future fertility 4) Military personnel going on deployment in war.

The published pilot data from The American Center for Reproductive Medicine has shown has shown that the NextGen ® kit provides a safe, reliable and convenient method for men to ship their samples to Cleveland Clinic from any part of the United States. Our data has demonstrated that the sperm quality and DNA integrity is well preserved  in samples collected offsite and shipped via the NextGen® kit.

This is a valuable, cost-effective alternative, especially for cancer patients who are instructed to bank multiple specimens in a short period of time in order to have adequate numbers of sperm that can be used for procreation by assisted reproductive techniques. These patients sometimes travel great distance (other cities or neighboring states) to find a sperm bank, take time off from work and incur significant travel expenses. Maintaining DNA integrity is critical for procreation and this has been validated in the recently published studies.

Andrology Center and Reproductive Tissue Bank

“Patients First” is the guiding principle of the Cleveland Clinic. To emulate this standard of care, our staff at the Andrology Center continually strives to provide compassionate care and outstanding service at every step of the way. The Andrology Center and Reproductive Tissue Bank's specialized facility is one of the largest of its kind in this country. It, offers a wide variety of comprehensive tests to evaluate male infertility using the latest technology to meet patient needs. As part of the American Center for Reproductive Medicine, the Andrology Center offers diagnostic tests and fertility preservation services to couples experiencing infertility and to men diagnosed with cancer.

Teaching and Research

The Center is known worldwide for conducting and publishing groundbreaking research with significant implications for disorders such as infertility and erectile dysfunction.

  • More than 600 published papers.
  • More than two dozen basic science and clinical research projects.
  • More than 100 papers published in peer-reviewed journals since January 2010.
  • More than 100 presentations at leading national and international medical and scientific conferences since January 2010.
  • Published over two dozen medical text books.


The high productivity of the program is reflected by the cutting edge research published at scientific meetings and leading journals in reproductive medicine.

  • Recipient of 2011 Innovator Award for the development of "Remote Sperm Banking Kits" from the Cleveland Clinic.
  • Scholarship in Teaching (SIT) Award, received in 2011, 2013 and 2014, Case Western University School of Medicine for excellent teaching and mentoring by the Center’s faculty.

Our Team

Dr. Agarwal

Ashok Agarwal,

Director, American Center for Reproductive Medicine


Center for Reproductive Medicine
Glickman Urological and Kidney Institute
Cleveland Clinic Main Campus
9500 Euclid Ave.
Cleveland, OH 44195

Please Note

The Andrology Lab on main campus has moved to the X Building on the corner of 105th and Carnegie.

Contact Us

Phone: 216.444.9485
Fax: 216.445.6049

Call us for an Appointment

Urology Appointments: 800.223.2273 ext. 4-5600
Nephrology Appointments: 800.223.2273 ext. 4-6771

Schedule an Appointment Online

Talk to a Nurse

Do you have a question about our services? Ask a nurse in the Glickman Urological & Kidney Institute.