Appointments

866.588.2264

Submit a Form

Questions

866.588.2264

Submit a Form

Expand Content

Clinical Trials

Clinical trials, the path to better treatment

We conduct clinical trials to advance new treatments and diagnostic approaches for patients with Alzheimer’s, Parkinson’s and Huntington’s disease, multiple sclerosis and frontotemporal dementia.

What are clinical trials and why are they conducted?

A clinical trial is a research process that is used to test new ways of treating disease.

There are many different types of clinical trials, from interventional (which include pill, infusion, device, diagnostic approach) to non-interventional (which include observations and follow-up without active treatment).

Clinical trials are the only way to test new drugs and advance treatment.

All drugs have to be tested in clinical trials to show they are safe and effective before they can be approved by the FDA to treat patients.

Why should I get involved with clinical trials?

Many people get involved because they want to help those suffering from a disease.

Others get involved to help themselves and because they will have access to the newest medication which is not available to the general public in addition to more comprehensive assessments.

The success of finding a new treatment depends on having enough patients to participate.

Your involvement is the key to finding cures and preventing the onset of brain diseases.

How do I participate?

Learn more about current trials at Cleveland Clinic Lou Ruvo Center for Brain Health:
Call: 702.685.7073
Email: brainhealth@ccf.org

You could do something today to make a difference for your family and your community. At your next visit, ask you doctor if clinical trials are right for you.

Current Clinical Trials

Professional Fighter Study

Location: Las Vegas
Participant: Active and retired professional fighters
Study Type: Observational Study
Duration: 4 years


TOMMORROW

Location: Las Vegas; Florida
Participant: Normal Cognition 65-83 years old
Study Type: Daily Oral Tablet (AD-4833 SR)
Duration: 5 years


A4

Location: Las Vegas
Participant: Normal Cognition 65-83 years old
Study Type: Monthly Infusion (Solanezumab)
Duration: 3 years


ASSESS

Location: Las Vegas; Cleveland Clinic Main Campus Mellen Center, OH
Participant: Multiple sclerosis 18-65 years old
Study Type: Daily Oral Tablet/Injection (Fingolimod/Glatiramer)
Duration: 15 months


EXPAND

Location: Las Vegas; Cleveland Clinic Main Campus Mellen Center, OH
Participant: Secondary-Progressive Multiple-sclerosis
Study Type: Daily Oral Tablet (BAF312)
Duration: 23 months to maximum 60 months


FORUM EnVivo

Location: Las Vegas; Florida
Participant: Alzheimer's Disease 55-85 years old
Study Type: Daily Oral Tablet (EVP-6124)
Duration: 26 weeks


Neuronix

Location: Las Vegas; Lakewood Hospital, OH
Participant: Mild to moderate Alzheimer's Disease, 60-90 years old
Study Type: Medical Device
Duration: 15 weeks


NOBLE

Location: Las Vegas
Participant: Alzheimer's Disease 55-85 years old
Study Type: Daily Oral Tablet (T-817MA)
Duration: 52 weeks


Lilly Expedition 3

Location: Las Vegas
Participant: Alzheimer's Disease 55-90 years old
Study Type: Monthly Infusion (Solanezumab)
Duration: 76 weeks


Enroll-HD

Location: Las Vegas
Participant: Huntington's Disease
Study Type: Observational Study
Duration: Longitudinal, yearly visit


ESTEEM

Location: Las Vegas; Cleveland Clinic Main Campus Mellen Center
Participant: Multiple Sclerosis patients 18 years of age and older.  For patients who have been prescribed Tecfidera ( Dimethyl Fumarate, an oral drug, DMF) under routine clinical care
Study Type: Observational Study
Duration: 5 years


Grifols

Location: Cleveland Clinic Main Campus, OH
Participant: Mild to moderate Alzheimer's Disease, ages 55-85 years old
Study Type: Treatment
Duration: 13 months


Rasagaline

Location: Las Vegas; Cleveland Clinic Main Campus, OH; Lakewood, OH
Participant: Mild to moderate Alzheimer's Disease, ages 50-90 years old
Study Type: Drug treatment
Duration: 28 weeks


Donepezil

Location: Cleveland Clinic Main Campus, OH
Participant: Have had a 1st degree relative diagnosed with Alzheimer's disease, ages 60-75 years old
Study Type: Drug treatment
Duration: 9 visits over 7-8 months


Stay tuned for more information on upcoming clinical trials: the NICE Study and the Prevention Study.

For more information on any of these studies, please call us toll free at 855.568.7886 or 702.483.6025 or email us at brainhealth@ccf.org

Although tremendous progress has been made in the past 2 decades, no cure or treatment that slows or stops the deterioration caused by Alzheimer's disease has been found. That's why research continues to be critically important.

The FDA requires that all drugs be investigated in clinical trials to show they are safe and effective before they can be approved to treat patients.

Cleveland Clinic Lou Ruvo Center for Brain Health is one of the leading sites in the country conducting advanced clinical trial and translational research. The center is at the forefront of developing new treatment and diagnostic approaches for patients with cognitive disorders.

We conduct clinical trials sponsored by pharmaceutical, biotechnological, device and diagnostic assessment companies. We support research activities funded by government grants, private foundation and other philanthropic sources. We provide a wide range of drug development services.

With our innovative clinical trial consortium, Cleveland Clinic Lou Ruvo Center for Brain Health is revolutionizing the clinical trial process. Under the visionary leadership of Jeffrey L. Cummings, MD, ScD, a world renowned AD expert, and Kate Zhong, MD, a geriatric psychiatrist and pharmacologist, the consortium is committed to advancing research and providing new treatments to our patients suffering from neurodegenerative disorders. Trial sites are located in Las Vegas, Nevada; Cleveland, Ohio (main campus); Lakewood, Ohio and Weston, Florida.

Using one confidential disclosure agreement (CDA), one institutional review board (IRB), one budget, one contract, one electronic medical record (EMR) and one standard operational procedure (SOP), the consortium is united under a highly centralized system. The ONE model facilitates exemplary trial conduct by providing large patient volume, streamlined operations, rapid start up, speedy enrollment, high retention and quality data.

For more information, please contact:
Samuel J. Hickson
Research Assistant/Recruitment Specialist
702.685.7073 or brainhealth@ccf.org

Together, we will Keep Memory Alive for many years and generations to come.

Meet the Research and Clinical Trials Team

Ohio
Additional Clinical Trial Team Members:
  • Rosemary Colleran, BSN, MPA
  • Athena Loughrin
  • Lyla Mourany
  • Christine Nelson, APRN, BC
  • Christine Reece
  • Hilda Sosic
  • Christine Whitman, RN
Florida
Additional Clinical Trial Team Members:
  • Milagros Formoso
  • Kathleen Knee, PsychD
  • Kateryna Kurako, MD
  • Lauren Thomas, PsychD
Nevada
Additional Clinical Trial Team Members:
  • Toni Castillo
  • Triny Cooper
  • Melissa Ellis, RN
  • Heath Gould
  • Samuel Hickson, BS, MSSA
  • Sarah Martin
  • Drew McDaniel
  • Joanne Moll Tudla, MD
  • Yolande Mucharbach
  • Michael Noback
  • Michelle Sholar, BA
  • Carol Varela
  • Gail Vranesh, RN, CCRC