Appointments

866.320.4573

Request an Appointment

Questions

800.223.2273

Contact us with Questions

Expand Content

Research & Publications

Research is an integral part of the mission of the Department of Infectious Disease. Our research efforts span infectious conditions and microbes and share a focus on clinical applicability to patients.

Ongoing research efforts are funded by both internal and external sources including the National Institutes of Health, the Bill and Melinda Gates Foundation, Clinical and Translational Scientific Collaboration, internal funding and pharmaceutical industry grants.

Research areas are highlighted below.

Bone and Joint Infections

Research interests in the Section of Bone and Joint Infections includes improvement in diagnostic algorithms using traditional and newer molecular techniques, prosthetic joint infections with drug-resistant pathogens, and improvement in processes of outpatient intravenous antibiotic therapy of bone and joint infections.

Members of the Section participated in a recently-completed trial comparing daptomycin, a newer antibiotic, to traditional drug treatment in staphylococcal infections of prosthetic knees and hips. Members of the Section have presented research and invited lectures at national meetings and serve on the Infectious Diseases Society of America’s panel constructing guidelines on the diagnosis and management of vertebral osteomyelitis (spine infections).

2012 Publications

  1. Fong KS, Tomford JW, Teixeira L, Fraser TG, van Duin D, Yen-Lieberman B, Gordon SM, Miranda C. Challenges of interferon-gamma release assay conversions in serial testing of health-care workers in a TB control program. Chest. 2012 Jul 1;142(1):55-62.
  2. Fong KS, Tomford JW, Teixeira L, Fraser TG, van Duin D, Yen-Lieberman B, Gordon SM, Miranda C. Challenges of interferon-gamma release assay conversions in serial testing of health-care workers in a TB control program. Chest. 2012 Jul 1;142(1):55-62.
  3. Ledtke C, Tomford JW, Jain A, Isada CM, van Duin D. Clinical presentation and management of histoplasmosis in older adults. J Am Geriatr Soc. 2012 Feb;60(2):265-270.
  4. Ledtke C, Rehm SJ, Fraser TG, Shrestha NK, Tan CD, Rodriguez ER, Tomford JW, Jain A, Lytle B, Johnston D, Sabik J, Gordon SM, van Duin D. Endovascular infections caused by Histoplasma capsulatum: a case series and review of the literature. Arch Pathol Lab Med. 2012 Jun;136(6):640-645.
  5. Shrestha NK, Bhaskaran A, Scalera NM, Schmitt SK, Rehm SJ, Gordon SM. Contribution of infectious disease consultation toward the care of inpatients being considered for community-based parenteral anti-infective therapy. J Hosp Med. 2012 May;7(5):365-369.
  6. Shrestha NK, Bhaskaran A, Scalera NM, Schmitt SK, Rehm SJ, Gordon SM. Antimicrobial stewardship at transition of care from hospital to community. Infect Control Hosp Epidemiol. 2012 Apr;33(4):401-404.
  7. Tungsiripat M, El-Bejjani D, Rizk N, Hu B, Ross AC, Walker UA, Lebrecht D, Milne G, Storer N, McComsey GA. Changes in inflammation, oxidative stress, mitochondrial DNA content after rosiglitazone in HIV lipoatrophy. J AIDS Clin Res. 2012;3(8):174.
  8. Yao Q, Englund KA, Hayden SP, Tomecki KJ. Tumor necrosis factor receptor associated periodic fever syndrome with photographic evidence of various skin disease and unusual phenotypes: case report and literature review. Semin Arthritis Rheum. 2012 Feb;41(4):611-617.

2011 Publications

  1. Schmitt, SK. Treatment and prevention of osteomyelitis following trauma. In: UpToDate, Basow, DS (Ed), UpToDate, Waltham, MA, 2011.

2012

  1. Gasbarre CC, Schmitt SK, Tomecki KJ. Antibiotics. In: Goldsmith LA, ed. Fitzpatrick's Dermatology in General Medicine. 8th ed. New York, NY: McGraw-Hill Medical; 2012. Chapter 230. p. 2776-2786.
  2. Schmitt SK. Diagnosis and management of prosthetic joint infection. In: Mandell BF, ed. Perioperative Management of Patients With Rheumatic Disease. New York, NY: Springer; 2012. Chapter 22. p. 261-269.
  3. Teixeira L. Prophylactic antibiotic use in patients with rheumatic diseases. In: Mandell BF, ed. Perioperative Management of Patients With Rheumatic Disease. New York, NY: Springer; 2012. Chapter 7. p. 87-90.
CoPAT - Community Outpatient Antimicrobial Therapy

2012 Publications

  1. Ledtke C, Rehm SJ, Fraser TG, Shrestha NK, Tan CD, Rodriguez ER, Tomford JW, Jain A, Lytle B, Johnston D, Sabik J, Gordon SM, van Duin D. Endovascular infections caused by Histoplasma capsulatum: a case series and review of the literature. Arch Pathol Lab Med. 2012 Jun;136(6):640-645.
  2. Malinis MF, Mawhorter SD, Jain A, Shrestha NK, Avery RK, van Duin D. Staphylococcus aureus bacteremia in solid organ transplant recipients: evidence for improved survival when compared with nontransplant patients. Transplantation. 2012 May 27;93(10):1045-1050.
  3. Manne MB, Shrestha NK, Lytle BW, Nowicki ER, Blackstone E, Gordon SM, Pettersson G, Fraser TG. Outcomes after surgical treatment of native and prosthetic valve infective endocarditis. Ann Thorac Surg. 2012 Feb;93(2):489-493.
  4. Shrestha NK, Bhaskaran A, Scalera NM, Schmitt SK, Rehm SJ, Gordon SM. Contribution of infectious disease consultation toward the care of inpatients being considered for community-based parenteral anti-infective therapy. J Hosp Med. 2012 May;7(5):365-369.
  5. Shrestha NK. Does the patient need IV drugs at discharge? Hospital Infection Control & Prevention. 2012 May;39(5):57-58.
  6. Shrestha NK, Bhaskaran A, Scalera NM, Schmitt SK, Rehm SJ, Gordon SM. Antimicrobial stewardship at transition of care from hospital to community. Infect Control Hosp Epidemiol. 2012 Apr;33(4):401-404.
  7. Shrestha NK, Wilson DA, Scalera NM, Oppedahl A, Procop GW. Immuno-flow cytometry for the rapid identification of Staphylococcus aureus and the detection of methicillin resistance. Eur J Clin Microbiol Infect Dis. 2012 Aug;31(8):1879-1882.
Endocarditis

The Cardiovascular Infections section of the Department of Infectious Disease is actively engaged in academic work describing our experience with complex patients treated for infective endocarditis, infections of cardiac implantable electrophysiological devices (CIEDs), and left ventricular assist devices.

Opportunities also exist for other patient populations with infections of the cardiovascular system including those with infections of peripheral vascular bypass grafts and those who have undergone endovascular repair of aortic aneurysms.

The focus of current projects has included the descriptive epidemiology of surgically and medically treated endocarditis, diagnostic and therapeutic approach to patients with infected CIEDs, metastatic complications of assist device infections, and the bioethical issues involved in the treatment of patients with assist device infection. The academic work of this section has been multidisciplinary and has included our cardiology, cardiac surgery, and bioethics colleagues.

2013 Publications

  1. Kattán JN, Gordon SM. Acute Uncomplicated Urinary Tract Infections. In: Carey WD, Abelson A, Dweik RA, Gordon SM, Hobbs R, Kothari S, Lang DM, Nurko S, Seballos RJ, Sekeres MA, Skugor M, Tavee J, Tesar GE, Tomecki KJ. Current Clinical Medicine. 3rd Ed. Cleveland: Saunders Elsevier, 2013 in print.
  2. Kattán JN, Rehm SJ, van Duin D, Petterson G, Rodríguez ER, Gordon SM. Whipple’s Disease: A Case Revisited 14 Years After Diagnosis. Inf Dis Clin Pract. 2013; 21(3):201-203.
  3. Moureau NL, Trick N, Nifong T, Perry C, Kelley C, Carrico R, Leavitt M, Gordon SM, Wallace J, Harvill M, Biggar C, Doll M, Papke L, Benton L, Phelan DA. Vessel health and preservation (Part 1): A new evidence-based approach to vascular access selection and management. J Vasc Access. 2012 Jul-Sep;13(3):351-356.

2012 Publications

  1. Andrawis MA, Rehm SJ. Health-system pharmacists' role in improving immunization rates. Am J Health Syst Pharm. 2012 Jan 1;69(1):74-76.
  2. Chen LF, Arduino JM, Sheng S, Muhlbaier LH, Kanafani ZA, Harris AD, Fraser TG, Allen K, Corey GR, Fowler VG, Jr. Epidemiology and outcome of major postoperative infections following cardiac surgery: Risk factors and impact of pathogen type. Am J Infect Control. 2012 Dec;40(10):963-968.
  3. Digiorgio MJ, Fatica C, Oden M, Bolwell B, Sekeres M, Kalaycio M, Akins P, Shane C, Bako J, Gordon SM, Fraser TG. Development of a modified surveillance definition of central line-associated bloodstream infections for patients with hematologic malignancies. Infect Control Hosp Epidemiol. 2012 Sep;33(9):865-868.
  4. Fong KS, Tomford JW, Teixeira L, Fraser TG, van Duin D, Yen-Lieberman B, Gordon SM, Miranda C. Challenges of interferon-gamma release assay conversions in serial testing of health-care workers in a TB control program. Chest. 2012 Jul 1;142(1):55-62.
  5. Fong KS, Banks M, Benish R, Fatica C, Triche M, Smith N, Butler R, Gordon SM, Fraser TG. Intensity of vascular catheter use in critical care: impact on catheter-associated bloodstream infection rates and association with severity of illness. Infect Control Hosp Epidemiol. 2012 Dec;33(12):1268-1270.
  6. Gordon SM, Pettersson GB. Native-valve infective endocarditis--when does it require surgery? N Engl J Med. 2012 Jun 28;366(26):2519-2521.
  7. Kattán JN, Park EJ, Mastracci TM, Dresing T, Gordon SM. Purpura fulminans associated with a cardiac implantable electronic device infection. Inf Dis Clin Pract. 2012. Publish Ahead of Print. POST AUTHOR CORRECTIONS, 11 September 2012 doi: 10.1097/IPC.0b013e31826991f4.
  8. Koch CG, Nowicki ER, Rajeswaran J, Gordon SM, Sabik JF, III, Blackstone EH. When the timing is right: Antibiotic timing and infection after cardiac surgery. J Thorac Cardiovasc Surg. 2012 Oct;144(4):931-937.
  9. Ledtke C, Rehm SJ, Fraser TG, Shrestha NK, Tan CD, Rodriguez ER, Tomford JW, Jain A, Lytle B, Johnston D, Sabik J, Gordon SM, van Duin D. Endovascular infections caused by Histoplasma capsulatum: a case series and review of the literature. Arch Pathol Lab Med. 2012 Jun;136(6):640-645.
  10. Malinis MF, Mawhorter SD, Jain A, Shrestha NK, Avery RK, van Duin D. Staphylococcus aureus bacteremia in solid organ transplant recipients: evidence for improved survival when compared with nontransplant patients. Transplantation. 2012 May 27;93(10):1045-1050.
  11. Manne MB, Shrestha NK, Lytle BW, Nowicki ER, Blackstone E, Gordon SM, Pettersson G, Fraser TG. Outcomes after surgical treatment of native and prosthetic valve infective endocarditis. Ann Thorac Surg. 2012 Feb;93(2):489-493.
  12. Rehm SJ, File TM, Metersky M, Nichol KL, Schaffner W. Identifying barriers to adult pneumococcal vaccination: an NFID task force meeting. Postgrad Med. 2012 May;124(3):71-79.
  13. Shrestha NK, Bhaskaran A, Scalera NM, Schmitt SK, Rehm SJ, Gordon SM. Contribution of infectious disease consultation toward the care of inpatients being considered for community-based parenteral anti-infective therapy. J Hosp Med. 2012 May;7(5):365-369.
  14. Shrestha NK, Bhaskaran A, Scalera NM, Schmitt SK, Rehm SJ, Gordon SM. Antimicrobial stewardship at transition of care from hospital to community. Infect Control Hosp Epidemiol. 2012 Apr;33(4):401-404.
  15. Shrestha NK. Does the patient need IV drugs at discharge? Hospital Infection Control & Prevention. 2012 May;39(5):57-58.
  16. Shrestha NK, Bhaskaran A, Scalera NM, Schmitt SK, Rehm SJ, Gordon SM. Antimicrobial stewardship at transition of care from hospital to community. Infect Control Hosp Epidemiol. 2012 Apr;33(4):401-404.
  17. Shrestha NK, Wilson DA, Scalera NM, Oppedahl A, Procop GW. Immuno-flow cytometry for the rapid identification of Staphylococcus aureus and the detection of methicillin resistance. Eur J Clin Microbiol Infect Dis. 2012 Aug;31(8):1879-1882.
  18. Son CH, Daniels TL, Eagan JA, Edmond MB, Fishman NO, Fraser TG, Kamboj M, Maragakis LL, Mehta SA, Perl TM, Phillips MS, Price CS, Talbot TR, Wilson SJ, Sepkowitz KA. Central line-associated bloodstream infection surveillance outside the intensive care unit: A multicenter survey. Infect Control Hosp Epidemiol. 2012 Sep;33(9):869-874.
  19. Tungsiripat M, El-Bejjani D, Rizk N, Hu B, Ross AC, Walker UA, Lebrecht D, Milne G, Storer N, McComsey GA. Changes in inflammation, oxidative stress, mitochondrial DNA content after rosiglitazone in HIV lipoatrophy. J AIDS Clin Res. 2012;3(8):174.
  20. Vinski J, Bertin M, Sun Z, Gordon SM, Bokar D, Merlino J, Fraser TG. Impact of isolation on hospital consumer assessment of healthcare providers and systems scores: is isolation isolating? Infect Control Hosp Epidemiol. 2012 May;33(5):513-516.

2011 Publications

  1. Idrees J, Albacker TB, Gordon SM, Shin J, Menon V, Roselli EE. Bartonella infective endocarditis of a prosthetic aortic valve with a subvalvular abscess. J Card Surg. 2011 Sep;26(5):483-485.
  2. O'Donoghue RD, Duncan AE, Fraser TG, Thomas JD. An echocardiographic evaluation of valvular function and ventricular patch repair during surgical exclusion of left ventricular pseudoaneurysm. Anesth Analg. 2011 Oct;113(4):713-716.
  3. Shrestha NK. Cardiovascular implantable electronic device infection: A complication of medical progress. Cleve Clin J Med. 2011 Aug;78(8):500-504.

2013

  1. Fraser TG. Principles of infection prevention and control. In: Kacmarek RM, Stoller JK, Heuer AJ, eds. Egan's Fundamentals of Respiratory Care. 10th ed. St. Louis, MO: Mosby Elsevier; 2013. Chapter 4. p. 61-82.
  2. Zimbwa P, Gordon SM. Infective endocarditis. In: Griffin BP, Kapadia SR, Rimmerman CM, eds. The Cleveland Clinic Cardiology Board Review. 2nd ed. Philadelphia, PA: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2013. Chapter 35. p. 505-521.
Granuloma

Research in granulomatous infections has centered on several areas. In the area of tuberculosis, we are interested in evaluating the implementation and interpretation of novel testing such as interferon-gamma release assays for latent tuberculosis, infection control of active tuberculosis, and novel diagnostics involving M. tuberculosis. We are also involved in clinical cohort studies of histoplasmosis in various hosts, such as solid organ transplant recipients and older adults. Lastly, we study the manifestations and outcomes of infections with non-tuberculous mycobacteria.

2013 Publications

  1. Taimur S, Johnson L. Dermatitis in an intestinal transplant candidate. Cleve Clin J Med. 2013 Feb;80(2):90.

2012 Publications

  1. Fong KS, Tomford JW, Teixeira L, Fraser TG, van Duin D, Yen-Lieberman B, Gordon SM, Miranda C. Challenges of interferon-gamma release assay conversions in serial testing of health-care workers in a TB control program. Chest. 2012 Jul 1;142(1):55-62.
  2. Kattán JN, Kalaycio M, van Duin D, Cober E. Resistance patterns of Klebsiella pneumoniae blood stream infections and impact in patients with hematological malignancies. In: Programs and Abstracts of the Infectious Disease Society of America (IDSA) IDWeekTM; October 2012; San Diego, CA. Control Number 1421.
  3. Ledtke C, Tomford JW, Jain A, Isada CM, van Duin D. Clinical presentation and management of histoplasmosis in older adults. J Am Geriatr Soc. 2012 Feb;60(2):265-270.
  4. Ledtke C, Rehm SJ, Fraser TG, Shrestha NK, Tan CD, Rodriguez ER, Tomford JW, Jain A, Lytle B, Johnston D, Sabik J, Gordon SM, van Duin D. Endovascular infections caused by Histoplasma capsulatum: a case series and review of the literature. Arch Pathol Lab Med. 2012 Jun;136(6):640-645.

2012

  1. Teixeira L. Prophylactic antibiotic use in patients with rheumatic diseases. In: Mandell BF, ed. Perioperative Management of Patients With Rheumatic Disease. New York, NY: Springer; 2012. Chapter 7. p. 87-90.
HIV Infections

The HIV research group at the Cleveland Clinic receives external funding from several sources including the National Institutes of Health, and the Bill and Melinda Gates Foundation. Two externally funded research programs are highlighted here:

Dr. Tungsiripat's main research interests focus on the study of the metabolic complications associated with HIV infection and its treatment. In particular, she is interested in the metabolic complications of cardiovascular disease, insulin resistance, and fat redistribution. She presently holds a NIH mentored career development award for the investigation of body fat distribution and cardiovascular complications of HV infection. Current studies are targeted towards understanding the mechanisms of these complications with the goal of preventing their development.

Dr. Abbas’ research interests cover mathematical and computational infectious disease epidemiology with a particular focus on HIV/AIDS. Her research group develops mathematical, statistical and computational models of the HIV epidemic and analyses the potential impact of prevention, treatment and control strategies. She is currently studying the impact of antiretroviral drugs used for pre-exposure prophylaxis (PrEP) and treatment (ART) of HIV, on the spread of HIV and drug resistance in resource-limited settings, such as South Africa.

She is the principal investigator on two research grants, awarded by the National Institutes of Health and the Bill & Melinda Gates Foundation. She is mentoring two full-time research fellows: Robert Glaubius, PhD; Computer Science and Engineering, and Anuj Mubayi, PhD; Applied Mathematics. Her collaborators include investigators at the University of Pittsburgh, Pittsburgh Supercomputing Center, Carnegie Mellon University and Imperial College London. Dr. Abbas is a participant of the HIV PrEP modeling meetings convened by the UNAIDS.

Areas of interest include:

  • HIV metabolic abnormalities of mitochondrial function, lipid metabolism and bone disease
  • Modeling studies of the HIV epidemic
  • Clinical trials of new drug therapeutics
  • Clinical metabolic bone disease
  • Organ transplantation in HIV infected patients
  • Other clinical and outcomes studies in HIV infection

2013 Publications

  1. Taege A. Organ transplantation and HIV progress or success? a review of current status. Curr Infect Dis Rep. 2013 Feb;15(1):67-76.

2012 Publications

  1. Fong KS, Tomford JW, Teixeira L, Fraser TG, van Duin D, Yen-Lieberman B, Gordon SM, Miranda C. Challenges of interferon-gamma release assay conversions in serial testing of health-care workers in a TB control program. Chest. 2012 Jul 1;142(1):55-62.
  2. Tungsiripat M, El-Bejjani D, Rizk N, Hu B, Ross AC, Walker UA, Lebrecht D, Milne G, Storer N, McComsey GA. Changes in inflammation, oxidative stress, mitochondrial DNA content after rosiglitazone in HIV lipoatrophy. J AIDS Clin Res. 2012;3(8):174.
  3. Yao Q, Englund KA, Hayden SP, Tomecki KJ. Tumor necrosis factor receptor associated periodic fever syndrome with photographic evidence of various skin disease and unusual phenotypes: case report and literature review. Semin Arthritis Rheum. 2012 Feb;41(4):611-617.

2011 Publications

  1. Abbas UL. Uptake of biomedical interventions for prevention of sexually transmitted HIV. Curr Opin HIV AIDS. 2011 Mar;6(2):114-118.
  2. Abbas UL, Hood G, Wetzel AW, Mellors JW. Factors influencing the emergence and spread of HIV drug resistance arising from rollout of antiretroviral pre-exposure prophylaxis (PrEP). MPLoS ONE. 2011;6(4):e18165.
  3. Lederman MM, Calabrese L, Funderburg NT, Clagett B, Medvik K, Bonilla H, Gripshover B, Salata RA, Taege A, Lisgaris M, McComsey GA, Kirchner E, Baum J, Shive C, Asaad R, Kalayjian RC, Sieg SF, Rodriguez B. Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells. J Infect Dis. 2011 Oct;204(8):1217-1226.
  4. Taege A. Seek and treat: HIV update 2011. Cleve Clin J Med. 2011 Feb;78(2):95-100.
  5. Tungsiripat M, El-Bejjani D, Rizk N, Dogra V, O'Riordan MA, Ross AC, Hileman C, Storer N, Harrill D, McComsey GA. Carotid intima media thickness, inflammatory markers, and endothelial activation markers in HIV patients with lipoatrophy increased at 48 weeks regardless of use of rosiglitazone or placebo. AIDS Res Hum Retroviruses. 2011 Mar;27(3):295-302.
  6. Abbas UL. Uptake of biomedical interventions for prevention of sexually transmitted HIV. Curr Opin HIV AIDS 6(2):114-118, March 2011.
  7. Taege A. Seek and treat: HIV update 2011. Cleve Clin J Med 78 (2): 95-100, 2011.
International Travel

2013 Publications

  1. Manuel O, Husain S, Kumar D, Zayas C, Mawhorter S, Levi ME, Kalpoe J, Lisboa L, Ely L, Kaul DR, Schwartz BS, Morris MI, Ison MG, Yen-Lieberman B, Sebastian A, Assi M, Humar A. Assessment of cytomegalovirus-specific cell-mediated immunity for the prediction of cytomegalovirus disease in high-risk solid-organ transplant recipients: a multicenter cohort study. Clin Infect Dis. 2013 Mar;56(6):817-824.
  2. Schwartz BS, Mawhorter SD. Parasitic infections in solid organ transplantation. Am J Transplant. 2013 Mar;13 Suppl 4:280-303.

2012 Publications

  1. Malinis MF, Mawhorter SD, Jain A, Shrestha NK, Avery RK, van Duin D. Staphylococcus aureus bacteremia in solid organ transplant recipients: evidence for improved survival when compared with nontransplant patients. Transplantation. 2012 May 27;93(10):1045-1050.

2012

  1. Ghoniem IA, Rabets JC, Mawhorter SD. Tuberculosis and other opportunistic infections of the genitourinary system. In: McDougal WS, ed. Campbell-Walsh Urology Tenth Edition Review. Philadelphia, PA: Elsevier/Saunders; 2012. Chapter 16. p. 80-84.
  2. Ghoniem IA, Rabets JC, Mawhorter SD. Tuberculosis and other opportunistic infections of the genitourinary system. In: Wein AJ, ed. Campbell-Walsh Urology. 10th ed. Philadelphia, PA: Elsevier/Saunders; 2012. Chapter 16. p. 468-492.
Neurological Infections

2012 Publications

  1. Isada CM. Safety issues in vasculitis: Infections and immunizations in the immunosuppressed host. Cleve Clin J Med. 2012 Nov;79 Suppl 3:S38-S45.
  2. Ledtke C, Tomford JW, Jain A, Isada CM, van Duin D. Clinical presentation and management of histoplasmosis in older adults. J Am Geriatr Soc. 2012 Feb;60(2):265-270.
  3. Neuner EA, Ahrens CL, Groszek JJ, Isada C, Vogelbaum MA, Fissell WH, Bhimraj A. Use of therapeutic drug monitoring to treat Elizabethkingia meningoseptica meningitis and bacteraemia in an adult. J Antimicrob Chemother. 2012 Jun;67(6):1558-1560.

2012

  1. Bhimraj A, Isada C. Brain abscess. In: Lynn DJ, Newton HB, Rae-Grant AD, eds. The 5-Minute Neurology Consult. 2nd ed. Philadelphia, PA: Wolters Kluwer/Lippincott Williams & Wilkins Health; 2012. p. 84-85.
Transplant Infectious Disease
Organ Transplant Infection Prevention

Members of the section of transplant infectious diseases are involved in a variety of research studies addressing several topics in this field, including:

  • Novel therapy of cytomegalovirus infection
  • Effects of viral infections on transplanted organs
  • Safety & effectiveness of vaccination in transplant recipients
  • Epidemiology & treatment of influenza in transplant recipients
  • Respiratory viral infections, including rhinovirus in transplant recipients
  • Outcome studies of donor lung bronchial cultures in lung transplant recipients
  • Epstein-barr virus infection in lung transplant recipients
  • Outcome studies of Staphylococcus aureus bacteremia in transplant recipients
  • Genetic markers predicting risk of infection, such as Killer Immunoglobulin Receptor (KIR), following transplantation
  • Strongyloidiasis in transplant candidates & recipients
  • Transplantation in HIV infected patients
  • The use of home intravenous antibiotics in transplant recipients
  • Pre-transplantation screening to decrease the risk of post-transplant infections
  • The use of probiotics to limit recurrences of Clostridium difficile infections

2013 Publications

  1. Koval CE, Rakita R. Ventricular assist device related infections and solid organ transplantation. Am J Transplant. 2013 Mar;13 Suppl 4:348-354.
  2. Loyaga-Rendon RY, Taylor DO, Koval CE. Progressive multifocal leukoencephalopathy in a heart transplant recipient following rituximab therapy for antibody-mediated rejection. Am J Transplant. 2013 Apr;13(4):1075-1079.
  3. Manuel O, Husain S, Kumar D, Zayas C, Mawhorter S, Levi ME, Kalpoe J, Lisboa L, Ely L, Kaul DR, Schwartz BS, Morris MI, Ison MG, Yen-Lieberman B, Sebastian A, Assi M, Humar A. Assessment of cytomegalovirus-specific cell-mediated immunity for the prediction of cytomegalovirus disease in high-risk solid-organ transplant recipients: a multicenter cohort study. Clin Infect Dis. 2013 Mar;56(6):817-824.
  4. Schwartz BS, Mawhorter SD. Parasitic infections in solid organ transplantation. Am J Transplant. 2013 Mar;13 Suppl 4:280-303.
  5. Taege A. Organ transplantation and HIV progress or success? a review of current status. Curr Infect Dis Rep. 2013 Feb;15(1):67-76.
  6. Taimur S, Johnson L. Dermatitis in an intestinal transplant candidate. Cleve Clin J Med. 2013 Feb;80(2):90.

2012 Publications

  1. Chamogeorgakis T, Koval CE, Smedira NG, Starling RC, Gonzalez-Stawinski GV. Outcomes associated with surgical management of infections related to the HeartMate II left ventricular assist device: Implications for destination therapy patients. J Heart Lung Transplant. 2012 Aug;31(8):904-906.
  2. Fong KS, Tomford JW, Teixeira L, Fraser TG, van Duin D, Yen-Lieberman B, Gordon SM, Miranda C. Challenges of interferon-gamma release assay conversions in serial testing of health-care workers in a TB control program. Chest. 2012 Jul 1;142(1):55-62.
  3. Ghattas C, Mossad SB. Fatal human metapneumovirus and influenza B virus coinfection in an allogeneic hematopoietic stem cell transplant recipient. Transpl Infect Dis. 2012 Oct;14(5):E41-E43.
  4. Jin XW, Mossad SB. 2012-2013 Influenza update: Hitting a rapidly moving target. Cleve Clin J Med. 2012 Nov;79(11):777-784.
  5. Kattán JN, Kalaycio M, van Duin D, Cober E. Resistance patterns of Klebsiella pneumoniae blood stream infections and impact in patients with hematological malignancies. In: Programs and Abstracts of the Infectious Disease Society of America (IDSA) IDWeekTM; October 2012; San Diego, CA. Control Number 1421.
  6. Koval CE. Home testing for HIV: Hopefully, a step forward. Cleve Clin J Med. 2012 Oct;79(10):713-716.
  7. Ledtke C, Rehm SJ, Fraser TG, Shrestha NK, Tan CD, Rodriguez ER, Tomford JW, Jain A, Lytle B, Johnston D, Sabik J, Gordon SM, van Duin D. Endovascular infections caused by Histoplasma capsulatum: a case series and review of the literature. Arch Pathol Lab Med. 2012 Jun;136(6):640-645.
  8. Li L, Avery R, Budev M, Mossad S, Danziger-Isakov L. Oral versus inhaled ribavirin therapy for respiratory syncytial virus infection after lung transplantation. J Heart Lung Transplant. 2012 Aug;31(8):839-844.
  9. Malinis MF, Mawhorter SD, Jain A, Shrestha NK, Avery RK, van Duin D. Staphylococcus aureus bacteremia in solid organ transplant recipients: evidence for improved survival when compared with nontransplant patients. Transplantation. 2012 May 27;93(10):1045-1050.
  10. Manne MB, Shrestha NK, Lytle BW, Nowicki ER, Blackstone E, Gordon SM, Pettersson G, Fraser TG. Outcomes after surgical treatment of native and prosthetic valve infective endocarditis. Ann Thorac Surg. 2012 Feb;93(2):489-493.
  11. Mossad SB. Posaconazole is not superior to itraconazole for fungal prophylaxis in allogeneic blood and marrow transplantation. Bone Marrow Transplant. 2012 Oct;47(10):1379.
  12. Raghuram A, Restrepo A, Safadjou S, Cooley J, Orloff M, Hardy D, Butler S, Koval CE. Invasive fungal infections following liver transplantation: Incidence, risk factors, survival, and impact of fluconazole-resistant Candida parapsilosis (2003-2007). Liver Transpl. 2012 Sep;18(9):1100-1109.
  13. Shrestha NK, Bhaskaran A, Scalera NM, Schmitt SK, Rehm SJ, Gordon SM. Contribution of infectious disease consultation toward the care of inpatients being considered for community-based parenteral anti-infective therapy. J Hosp Med. 2012 May;7(5):365-369.
  14. Shrestha NK. Does the patient need IV drugs at discharge? Hospital Infection Control & Prevention. 2012 May;39(5):57-58.
  15. Shrestha NK, Bhaskaran A, Scalera NM, Schmitt SK, Rehm SJ, Gordon SM. Antimicrobial stewardship at transition of care from hospital to community. Infect Control Hosp Epidemiol. 2012 Apr;33(4):401-404.
  16. Shrestha NK, Wilson DA, Scalera NM, Oppedahl A, Procop GW. Immuno-flow cytometry for the rapid identification of Staphylococcus aureus and the detection of methicillin resistance. Eur J Clin Microbiol Infect Dis. 2012 Aug;31(8):1879-1882.
  17. Wojewoda CM, Koval CE, Wilson DA, Chakos MH, Harrington SM. Bloodstream infection caused by nontoxigenic Corynebacterium diphtheriae in an immunocompromised host in the United States. J Clin Microbiol. 2012 Jun;50(6):2170-2172.

2011 Publications

  1. Avery RK. Low-dose valganciclovir for cytomegalovirus prophylaxis in organ transplantation: is less really more? Clin Infect Dis. 2011 Feb;52(3):322-324.
  2. Avery RK. Antifungal prophylaxis in lung transplantation. Semin Respir Crit Care Med. 2011 Dec;32(6):717-726.
  3. Finlen Copeland CA, Davis WA, Snyder LD, Banks M, Avery R, Davis RD, Palmer SM. Long-term efficacy and safety of 12 months of valganciclovir prophylaxis compared with 3 months after lung transplantation: A single-center, long-term follow-up analysis from a randomized, controlled cytomegalovirus prevention trial. J Heart Lung Transplant. 2011 Sep;30(9):990-996.
  4. Gordon CR, Avery RK, Abouhassan W, Siemionow M. Cytomegalovirus and other infectious issues related to face transplantation: specific considerations, lessons learned, and future recommendations. Plast Reconstr Surg. 2011 Apr;127(4):1515-1523.
  5. Gordon CR, Abouhassan W, Avery RK. What is the true significance of donor-related cytomegalovirus transmission in the setting of facial composite tissue allotransplantation? Transplant Proc. 2011 Nov;43(9):3516-3520.
  6. Hannan MM, Husain S, Mattner F, Danziger-Isakov L, Drew RJ, Corey GR, Schueler S, Holman WL, Lawler LP, Gordon SM, Mahon NG, Herre JM, Gould K, Montoya JG, Padera RF, Kormos RL, Conte JV, Mooney ML. Working formulation for the standardization of definitions of infections in patients using ventricular assist devices. J Heart Lung Transplant. 2011 Apr;30(4):375-384.
  7. Husain S, Mooney ML, Danziger-Isakov L, Mattner F, Singh N, Avery R, Ison M, Humar A, Padera RF, Lawler LP, Fisher A, Drew RJ, Gould KF, Sole A, Studer S, Munoz P, Singer LG, Hannan M. A 2010 working formulation for the standardization of definitions of infections in cardiothoracic transplant recipients. J Heart Lung Transplant. 2011 Apr;30(4):361-374.
  8. Kaul DR, Stoelben S, Cober E, Ojo T, Sandusky E, Lischka P, Zimmermann H, Rubsamen-Schaeff H. First report of successful treatment of multidrug-resistant cytomegalovirus disease with the novel anti-CMV compound AIC246. Am J Transplant. 2011 May;11(5):1079-1084.
  9. Kumar D, Blumberg EA, Danziger-Isakov L, Kotton CN, Halasa NB, Ison MG, Avery RK, Green M, Allen UD, Edwards KM, Miller G, Michaels MG. Influenza vaccination in the organ transplant recipient: review and summary recommendations. Am J Transplant. 2011 Oct;11(10):2020-2030.
  10. Mangi AA, Mason DP, Nowicki ER, Batizy LH, Murthy SC, Pidwell DJ, Avery RK, McCurry KR, Pettersson GB, Blackstone EH. Predictors of acute rejection after lung transplantation. Ann Thorac Surg. 2011 Jun;91(6):1754-1762.
  11. Mason DP, Murthy SC, Yun JJ, Machuzak M, Shrestha R, Avery RK, McCurry KR, Budev MM, Pettersson GB. Lung transplantation in a recipient with novel 2009 H1N1 influenza: Lessons learned. Thorac Cardiovasc Surg. 2011 Mar;59(2):126-127.
  12. Mossad SB. Region-specific challenges for minimizing endemic donor-transmitted infections. Liver Transpl. 2011 Nov;17(11):1241-1243.
  13. Sobecks RM, Askar M, Thomas D, Rybicki L, Kalaycio M, Dean R, Avery R, Mossad S, Copelan E, Bolwell BJ. Cytomegalovirus reactivation after matched sibling donor reduced-intensity conditioning allogeneic hematopoietic stem cell transplant correlates with donor killer immunoglobulin-like receptor genotype. Exp Clin Transplant. 2011 Feb;9(1):7-13.
  14. Watcharananan SP, Avery R, Ingsathit A, Malathum K, Chantratita W, Mavichak V, Chalermsanyakorn P, Jirasiritham S, Sumethkul V. Adenovirus disease after kidney transplantation: course of infection and outcome in relation to blood viral load and immune recovery. Am J Transplant. 2011 Jun;11(6):1308-1314.
  15. Avery RK. Low-dose valganciclovir for cytomegalovirus prophylaxis in organ transplantation: is less really more? Clin Infect Dis 52 (3): 322-4, 2011.

2012

  1. Bhimraj A, Isada C. Brain abscess. In: Lynn DJ, Newton HB, Rae-Grant AD, eds. The 5-Minute Neurology Consult. 2nd ed. Philadelphia, PA: Wolters Kluwer/Lippincott Williams & Wilkins Health; 2012. p. 84-85.
  2. Ghoniem IA, Rabets JC, Mawhorter SD. Tuberculosis and other opportunistic infections of the genitourinary system. In: McDougal WS, ed. Campbell-Walsh Urology Tenth Edition Review. Philadelphia, PA: Elsevier/Saunders; 2012. Chapter 16. p. 80-84.
  3. Ghoniem IA, Rabets JC, Mawhorter SD. Tuberculosis and other opportunistic infections of the genitourinary system. In: Wein AJ, ed. Campbell-Walsh Urology. 10th ed. Philadelphia, PA: Elsevier/Saunders; 2012. Chapter 16. p. 468-492.
  4. Teixeira L. Prophylactic antibiotic use in patients with rheumatic diseases. In: Mandell BF, ed. Perioperative Management of Patients With Rheumatic Disease. New York, NY: Springer; 2012. Chapter 7. p. 87-90.