At Cleveland Clinic Asthma Center, we offer the most advanced diagnostic testing and innovative treatments for adults and children with asthma. Within Cleveland Clinic Respiratory Institute, the Asthma Center brings together physicians from allergy and immunology, pulmonary and critical care, and sports medicine (for asthma in elite athletes). For those with asthma and co-existing conditions, such as sinusitis, gastroesophageal reflux, vocal cord dysfunction, cataracts, glaucoma or osteoporosis, we also coordinate your care with specialists in gastroenterology, ophthalmology, otolaryngology, osteoporosis and metabolic bone disease, and speech therapy. Our integrated approach to patient care provides you with state-of-the-art diagnostic and treatment services and opportunities to try new medications and therapies through clinical trials.


We offer a full range of clinical services including:

  • Comprehensive consultation services and ongoing care for refractory asthma (poorly-controlled asthma)
  • Occupational and environmental asthma evaluation
  • Bronchoprovocation testing with methacholine, cold air and exercise
  • Testing for suspected sensitivity to foods, food additives, aspirin and allergens
  • Specialized testing to determine how well your asthma is being controlled
  • Treatment for asthma, and coexisting conditions that complicate asthma control
  • Initial management plans for newly diagnosed asthma cases and continued care when needed
  • Comprehensive patient education

Novel Diagnostic and Treatment Approaches

Our physicians have a particular expertise in refractory asthma, or poorly-controlled asthma. For patients with refractory asthma, the Asthma Center offers innovative diagnostic and treatment services that are at the forefront of asthma care including:

  • Measurement of inflammatory biomarkers in exhaled breath for patients not responding to therapies, and requiring high doses of corticosteroids
  • Bronchoscopic evaluation to identify potential chronic causes of asthma
  • Anti-IgE therapy
  • Bronchial thermoplasty, a new technique designed to reduce the contractility of airway smooth muscle by applying radiofrequency energy to airway walls
  • Aspirin desensitization to develop tolerance to aspirin and similar drugs for patients with aspirin-exacerbated respiratory disease

Make an Appointment

Request an appointment today with one of our asthma specialists. Call the Asthma Center at 216.444.0582 or toll-free 800.223.2273, ext. 40582.

Health Information

Health Information

One of the most common chronic diseases in the world, asthma has become more prevalent and more severe in recent years. Asthma causes the airways of the lungs (bronchial tubes) to narrow, the lining of the airways to swell, and the cells that line the airways to produce more mucus. These changes make breathing difficult and cause symptoms, such as cough, shortness of breath, wheezing, chest tightness and excess mucus production. Learn about symptoms, causes and triggers, diagnostic testing, treatments and management tips for asthma below.

Asthma Overview

Asthma Symptoms, Causes and Triggers

Asthma Testing

Asthma Treatment and Management

Using an Inhaler

Asthma in Special Populations

More Information



Research & Clinical Trials

Research & Clinical Trials

The Asthma Center is a forerunner in developing new treatments through clinical trials and conducting translational research that supports and enhances patient care.

Asthma Research & Clinical Trials

Air Pollution and Asthma

Researchers at the Asthma Center are involved in a unique research partnership with the U.S. Environmental Protection Agency to evaluate whether hospital presentations for asthma in Northeast Ohio are temporally associated with poor air quality, and whether certain sources of air pollution may partially explain patterns of hospital presentations. Our preliminary work has demonstrated that proximity to major highways and roadways is a risk factor in asthma morbidity.

Study For Adolescents and Adults with Persistent Asthma

A global, randomized, active-controlled, parallel-group, multi-site, doubleblind study designed to compare serious asthma outcomes in adult and adolescent subjects with persistent asthma treated with Mometasone Furoate/Formoterol Fumarate (MF/F) MDI BID versus those treated with Mometasone Furoate (MF) MDI Monotherapy BID. Additionally, to demonstrate the risk/benefit of MF/F compared with MF in the same study population, this study will evaluate whether the addition of F to MF reduces the risk of asthma exacerbation relative to MF alone. For more information, please contact Elizabeth Maierson, RRT at 216.444.2901


This study will evaluate two dose regimens of mepolizumab [75mg intravenous (i.v.) or 100mg subcutaneous (SC) every 4 weeks] compared with placebo over a 32 week treatment period in subjects with severe refractory asthma with elevated blood eosinophils. For more information, please contact JoAnne Baran, RN, BSN at 216.444.5023

Imaging Inflammation in Asthma

The purpose of this research is to assess lung inflammation in individuals with asthma compared with healthy controls. For more information, please contact Emmea Mattox at 216.445.1756

Post-FDA Approval Clinical Trial Evaluating Bronchial Thermoplasty in Severe Persistent Asthma (PAS2)

The objective of this study is to evaluate durability of treatment effect and to continue to evaluate the short- and longterm safety profile of the Alair® System in patients with severe persistent asthma. For more information, please contact JoAnne Baran, RN, BSN at 216.444.5023

cKit Inhibition in Asthma (KIA)

This is a 30 to 34 week, treatment-randomized, double-blind, placebo-controlled study of the effects of cKit inhibition by imatinib in patients with severe refractory asthma (KIA).For more information, please contact Jackie Sharp, CNP at 216.636.0000

Severe Asthma Research Program

Cleveland Clinic is collaborating with the National Institutes of Health in the Severe Asthma Research Program (SARP), an observational study to better characterize asthma’s pathology. Through such NIH-sponsored research programs and investigator-initiated studies, Asthma Center investigators are making advances in the understanding of the pathophysiology of asthma, therapeutic targets for asthma, and epidemiology of asthma. Moreover, profiling of asthma enables physicians to better determine which patients will benefit from various therapeutic modalities, such as biologic therapies or interventions, such as bronchial thermoplasty.

Recommended Research Readings

View helpful research publications on the topic of asthma below:

For Medical Professionals

For Medical Professionals

Patient Referrals

Following a patient evaluation at the Asthma Center, our team provides a timely, specialized report that includes our evaluation, test results and a proposed plan of care. Our specialists may assume care for patients or provide a treatment plan to you and the patient to carry out proposed recommendations.

Our secure online service, Dr.Connect, provides referring physicians access to patient’s treatment progress with streamlined communication from Cleveland Clinic physicians to your office, allowing continued participation in the ongoing care of patients. With the best possible treatment plans and coordinated care, our team approach benefits both the patient and the referring physician.

To refer a patient, call the Asthma Center at 216.444.0582 or the Bronchial Thermoplasty Referral Line at 216.445.6266.


Allergy and Clinical Immunology Fellowships

Cleveland Clinic Respiratory Institute offers two fellowships in allergy/immunology each year. Fellows will gain experience working in a multi-specialty group practice setting, with a busy outpatient allergy/immunology practice and have the opportunity to do elective rotations in asthma, dermatology, otolaryngology, pulmonary and critical care, radiology, rheumatology, infectious diseases, and more. Learn more about our allergy/immunology fellowships.

Pulmonary and Critical Care Medicine Fellowships

Our pulmonary and critical care medicine fellowships provide board-certified general internists with the tools necessary to care for patients, who have complicated lung diseases and critical illnesses. During the three-year training period, which includes an 18-month core program and 18-month subspecialty track, fellows are exposed to a wide variety of medical problems in both the inpatient and outpatient settings. Learn more about our pulmonary and critical care medicine fellowships.


The Cleveland Clinic Respiratory Institute offers continuing medical education courses through the Center for Continuing Education. Current CME offerings include:


Disease Management Project

Cleveland Clinic publishes an online medical reference, the Disease Management Project, which provides nationally-established treatment guidelines for the most common diseases and conditions. View an overview of diagnostic and treatment guidelines for asthma.

Web Resources