The HIV research group at the Cleveland Clinic receives external funding from several sources including the National Institutes of Health, and the Bill and Melinda Gates Foundation. Two externally funded research programs are highlighted here:
Dr. Tungsiripat's main reseearch interests focus on the study of the metabolic complications associated with HIV infection and its treatment. In particular, she is interested in the metabolic complications of cardiovascular disease, insulin resistance, and fat redistribution. She presently holds a NIH mentored career development award for the investigation of body fat distribution and cardiovascular complications of HV infection. Current studies are targeted towards understanding the mechanisms of these complications with the goal of preventing their development.
Dr. Abbas’ research interests cover mathematical and computational infectious disease epidemiology with a particular focus on HIV/AIDS. Her research group develops mathematical, statistical and computational models of the HIV epidemic and analyses the potential impact of prevention, treatment and control strategies. She is currently studying the impact of antiretroviral drugs used for pre-exposure prophylaxis (PrEP) and treatment (ART) of HIV, on the spread of HIV and drug resistance in resource-limited settings, such as South Africa.
She is the principal investigator on two research grants, awarded by the National Institutes of Health and the Bill & Melinda Gates Foundation. She is mentoring two full-time research fellows: Robert Glaubius, PhD; Computer Science and Engineering, and Anuj Mubayi, PhD; Applied Mathematics. Her collaborators include investigators at the University of Pittsburgh, Pittsburgh Supercomputing Center, Carnegie Mellon University and Imperial College London. Dr. Abbas is a participant of the HIV PrEP modeling meetings convened by the UNAIDS.
Areas of interest include:
- HIV metabolic abnormalities of mitochondrial function, lipid metabolism and bone disease
- Modeling studies of the HIV epidemic
- Clinical trials of new drug therapeutics
- Clinical metabolic bone disease
- Organ transplantation in HIV infected patients
- Other clinical and outcomes studies in HIV infection