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Jonathan Smith, PhD

Jonathan Smith, Ph.D.

Appointed: 2002

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Jonathan Smith, PhD
Department: Cellular and Molecular Medicine
Location: Cleveland Clinic Main Campus
Mail Code NC10
9500 Euclid Avenue
Cleveland, OH 44195
Jonathan Smith, PhD
Department: Cardiovascular Medicine
Location: Cleveland Clinic Main Campus
Mail Code NC10
9500 Euclid Avenue
Cleveland, OH 44195
Type of Doctor:

Biographical Sketch

Dr. Jonathan D. Smith, PhD, is the Geoffrey Gund Endowed Chair for Cardiovascular Research.  He is Staff in the Department of Cellular & Molecular Medicine in the Cleveland Clinic Lerner Research Institute. Additionally he is a Professor of Molecular Medicine in the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University.  He serves as the Director of the Molecular Medicine PhD Program at the Cleveland Clinic and Case Western Reserve University.  Dr. Smith received his PhD in Cellular and Developmental Biology in 1984 from the Division of Medical Sciences, Harvard University. He continued his education with postdoctoral training at Rockefeller University. Prior to joining the Cleveland Clinic in 2002, he was an Associate Professor in the Laboratory of Biochemical Genetics and Metabolism at Rockefeller University.

In the course of his education and professional service he has received several awards, including the National Research Service Award from the National Institutes of Health, the Investigatorship Award from the American Heart Association of New York, the Established Investigatorship Award from the American Heart Association,  the Outstanding Educator Award of Excellence from the Cleveland Clinic Lerner Research Institute, the Arteriosclerosis Special Recognition Award from the American Heart Association Council on Arteriosclerosis, Thrombosis, and Vascular Biology, and in 2016 he was selected as the inaugural holder of the Geoffrey Gund Endowed Chair for Cardiovascular Research at the Cleveland Clinic.

Dr. Smith’s research interests include the use of cell biology, genetics, and functional genomics to unravel the mechanisms for and susceptibility to cardiovascular diseases such as atherosclerosis and atrial fibrillation.  He also studies cholesterol and lipoprotein metabolism.  He is currently involved in four research projects supported by grants from the National Institutes of Health. His prolific research endeavors have been published in leading peer-reviewed scientific journals. He currently serves on the editorial board of the journal Arteriosclerosis, Thrombosis, and Vascular Biology.

Education & Fellowships

Doctorate - Harvard University
Cellular & Developmental Biolo
Cambridge, MA USA
Undergraduate - University of California-Santa Cruz
Santa Cruz, CA USA

Specialty Interests

molecular genetics, atherosclerosis research, Alzheimers' Disease research


  • American Heart Association
  • AAAS

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 1/12/2016, Dr. Smith has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Smith receives fees of $5,000 or more per year as a paid consultant, speaker or member of an advisory committee for the following companies:

  • Esperion Therapeutics, Inc.
  • Lilly USA, LLC

Royalty Payments. Dr. Smith receives or has the right to receive royalty payments for inventions or discoveries commercialized through the companies shown below:

  • Cleveland HeartLab, Inc.
  • Esperion Therapeutics, Inc.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers’ discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Languages Spoken

  • English