James Kaltenbach, PhD

216.444.5171

James Kaltenbach, Ph.D.

Appointed: 2008

James Kaltenbach, PhD
Department: Neurosciences
Location: Cleveland Clinic Main Campus
Mail Code NC30
9500 Euclid Avenue
Cleveland, OH 44195
WorkAppointment:216.444.5171
WorkFax:216.444.7927
James Kaltenbach, PhD
Department: Otolaryngology
Location: Cleveland Clinic Main Campus
Mail Code NC30
9500 Euclid Avenue
Cleveland, OH 44195
WorkAppointment:216.444.5171
WorkFax:216.444.7927
Surgeon:
No
Treats:
Adults Only

Biographical Sketch

Publications

1. Kaltenbach, J. A.  The spectral and temporal response patterns of single units in the chinchilla dorsal cochlear nucleus. Doctoral dissertation, 1984.  (Ann Arbor: University Microfilms, 1985).

2. Kaltenbach, J. A., & Gerstein, G. L. (1986). A rapid method for the production of sharp tips on preinsulated microwires. Journal  of Neuroscience Methods, 16, 283-288.

3. Kaltenbach, J. A., & Saunders, J. C. (1987). The spectral and temporal response patterns of single units in the chinchilla dorsal cochlear nucleus.  Experimental Neurology, 96, 406-419.

4. Sarna, M. Gochin, P. M., Kaltenbach, J. A., Salganicoff, M., Gerstein, G. L. (1988). Unsupervised waveform classification  for multineuron recordings: A real-time software-based system. II. Performance comparison to other sorter systems for neural waveforms. Journal of Neuroscience Methods, 25, 189-196.

5. Kaltenbach, J. A., Gochin, P. M., & Gerstein, G. L. (1989). Spectral time course analysis of firing patterns in the dorsal cochlear nucleus. Hearing Research, 41, 107-114.

6. Gochin, P. M., Kaltenbach, J. A., & Gerstein, G. L. (1989). Coordinated activity of excitatory interactions of neuron pairs in anesthetized rat dorsal cochlear nucleus. Brain Research, 494, 1-11.

7. Gochin, P. M., Gerstein, G. L., & Kaltenbach, J. A. (1990). Dynamic temporal properties of effective connections in rat dorsal cochlear nucleus.  Brain Research, 510, 195-202.

8. Kaltenbach, J. A., & Lazor, J. (1991). Tonotopic maps obtained from the surface of the dorsal cochlear nucleus of the hamster and rat. Hearing Research, 51, 149-160.

9. Kaltenbach, J., Czaja, J., & Kaplan, C. (1992). Changes in the tonotopic map of the dorsal cochlear nucleus following induction of cochlear lesions by exposure to intense sounds. Hearing Research, 59, 213-223.

10. Kaltenbach, J., Schmidt, R.N., & Kaplan, C. (1992). Tone-induced stereocilia lesions as a function of exposure level and duration in the hamster cochlea.  Hearing Research, 60, 205-215.

11. Kaltenbach, J. A., Meleca, R., Falzarano, P., Myers, S., & Simpson, T. (1993). Forward masking properties of neurons in the dorsal cochlear nucleus and their possible contribution to the process of echo suppression.  Hearing Research, 67, 35-44.

12. Church, M. W., & Kaltenbach, J. A. (1993).  The hamsters brainstem auditory evoked potential (BAEP) as a function of tone burst frequency, intensity, and sensorineural hearing loss. Ear & Hearing, 14, 249-257.

13. Simpson, T. H., Stewart, M., & Kaltenbach, J. A. (1993). Effects of audiometric threshold step size on proposed ANSI S12.13 outcomes for characterizing hearing conservation program effectiveness.  Journal of the American Academy of Audiology, 4, 258-263.

14. Kaltenbach, J. A., & Falzarano, P.  (1994).  Postnatal development of the hamster cochlea I.  Growth of hair cells and organ of Corti.  Journal of Comparative Neurology, 340, 87-97.

15. Simpson, T. H., Stewart, T. M., & Kaltenbach, J. A.  (1994). Early indicators of hearing   conservation program performance. Journal of the American Academy of Audiology, 5, 300-306.    

16. Kaltenbach, J. A., Falzarano, P. & Simpson, T.  (1994). Postnatal development of the hamster cochlea II.  Stereocilia growth and differentiation. Journal of Comparative Neurology, 350, 187-198.

17. Coleman, G., Kaltenbach, J. A. & Falzarano, P. R. (1995). Postnatal development of the mammalian tectorial membrane. American Journal of Otology. 16, 620-631. 

18. Church, M. W., & Kaltenbach, J. A. (1995).  The comparative effects of sodium thiosulfate, diethyl dithiocarbamate, fosfomycin and WR-2721 on ameliorating cisplatin-induced ototoxicity. Hearing Research, 86, 195-203.

19. Quirk, W. S., Goldwyn, B. S., Meleca, R. & Kaltenbach, J. A. (1996)  Dorsal cochlear nucleus blood flow during acoustic stimulation. Otolaryngology-Head  and Neck Surgery, 114, 613-619.

20. Church, M. W., Abel, E.L., Kaltenbach, J. A., and Overbeck, G. W. (1996) Effects of prenatal alcohol exposure and aging on auditory function in the rat: preliminary results. Alcoholism: Clinical and Experimental Research, 20, 172-179.

21. Kaltenbach, J. A., & McCaslin, D.  (1996) Increases in spontaneous activity in the dorsal cochlear nucleus neurons following exposure to high intensity sound: a possible neural correlate of tinnitus.  Auditory Neuroscience, 3, 57-78.      

22. Meleca, R. J., Kaltenbach, J. A., & Falzarano, P. R. (1997)  Changes in the tonotopic map of the dorsal cochlear nucleus following degeneration of hair cells and primary afferent fibers. Brain Research, 750, 201-213.  

23. Mandal, A., Quirk, W. S., & Kaltenbach, J. A.  (1997) Noise-induced changes in blood flow over the surface of the dorsal cochlear nucleus. Hearing Research, 106, 1-8.

24. Myers, S.F., H.H. Salem, and Kaltenbach, J.A. (1997) Efferent neurons and vestibular cross talk in the frog. Journal of Neurophysiology 77, 2061-2070.

25. Church, M. W., & Kaltenbach, J. A. (1997)  Hearing, speech, language, and vestibular disorders in the fetal alcohol syndrome: a literature review. Alcoholism: Clinical and Experimental Research, 21, 495-512.

26. Kaltenbach, J.A., Blakely, B., Church, M., McCaslin, D. and Burgio, D. (1997) Comparison of five agents in protecting the cochlea against the ototoxic effects of cisplatin in the hamster. Otolaryngology/Head and Neck Surgery, 117, 493-504.

27. Kaltenbach, J.A. and Falzarano, P.R. (1997) Development of the reticular lamina in the Syrian golden hamster. Invited paper for special issue dedicated to Inner Ear Development. Int. J. of Devel. Neurosci. 15, 509-521.

28. Kaltenbach, J.A., Godfrey, D.A., Neumann, J.B., McCaslin, D.L., Afman, C. and Zhang, J. (1998) Changes in spontaneous neural activity in the dorsal cochlear nucleus following exposure to intense sound: Relation to threshold shift. Hearing Res. 124, 78-84.

29. Zhang, J. and Kaltenbach, J.A. (1998) Increases in spontaneous activity in the dorsal cochlear nucleus of the rat following exposure to high intensity sound. Neurosci. Lett. 250, 197-200.

30. Kaltenbach, J.A., Heffner, H.E., and Afman, C.E. (1999) Effects of intense sound on spontaneous activity in the dorsal cochlear nucleus and its relation to tinnitus. Proc. VIth Internat. Tinn. Sem. 6: 133-138.

31. Godfrey, D.A., Mikesell, N.L., Godfrey, T.G., Fulcomer, A.B., Kong, W., Zhang, J., and Kaltenbach, J.A. (1999) Proc. VIth Internat. Tinn. Sem. 6: 203-208.

32. Chen, K., Chang, H., Zhang, J., Kaltenbach, J.A., and Godfrey, D.A., (1999) Altered spontaneous activity in rat dorsal cochlear nucleus following loud sound exposure. Proc. VIth Internat. Tinn. Sem. 6: 212-217.

33. Melamed, S.B., Kaltenbach, J.A., Church, M.W., Burgio, D.L., and Afman, C.E. (1999) Cisplatin-induced increases in spontaneous neural activity in the dorsal cochlear nucleus and associated outer hair cell loss. Audiology 39, 24-29.

34. Kaltenbach, J.A. (1999) Neurophysiological mechanisms of tinnitus. Invited paper for special issue of Journal of the American Academy of Audiology. 11, 125-137.

35. Zhang, J. and Kaltenbach, J.A. (2000) Modulation of spontaneous activity by muscarinic receptors in the rat dorsal cochlear nucleus, in vivo. Hearing Res. 140, 7-17.

36. Kaltenbach, J.A. and Afman, C. (2000) Hyperactivity in the dorsal cochlear nucleus after intense sound exposure and its resemblance to tone-evoked activity: A physiological model for tinnitus. Hearing Res. 140, 165-172.

37. Kaltenbach, J.A., Zhang, J , and Afman, C.E. (2000) Plasticity of neural activity in the dorsal cochlear nucleus after intense sound exposure Hearing Res. 147, 282-292.

38. Bahu, S., Kaltenbach, J.A., Hnatiuk, M. Khariwhala, S., and Zhang, J. (2001) Expression of c-fos in the dorsal cochlear nucleus as a function of stimulus frequency in the hamster. Neuroscience Research Communications 29, 107-117. 

39. Chang, H., Chen, K., Kaltenbach, J.A. Zhang, J. and Godfrey, D.A. (2002) Effects of acoustic trauma on dorsal cochlear nucleus neuron activity in slices. Hearing Res. 164, 59-68.

40. Rachel, J.D., Kaltenbach, J.A. and Janisse, J. (2002) Increases in spontaneous neural activity in the hamster dorsal cochlear nucleus following cisplatin treatment: a possible basis for cisplatin-induced tinnitus, Hearing Research 164, 206-214.

41. Kaltenbach, J.A., Rachel, J.D., Mathog, A.T., Zhang, J., Falzarano, P.R., and Lewandowski, M. (2002) Cisplatin-induced hyperactivity in the dorsal cochlear nucleus and its relations to outer hair cell loss: Implications for an understanding of tinnitus. J. Neurophysiol. 88: 699-714.

42. Zacharek, M.A., Kaltenbach, J.A., Mathog, T.A. and Zhang, J. (2002). Effects of cochlear ablation on noise induced hyperactivity in the hamster dorsal cochlear nucleus: implications on the origin of noise-induced tinnitus. Hearing Res. 172: 137-144.

43. Zhang JS, Kaltenbach JA, Wang J. (2003) Fos-like immunoreactivity in auditory and nonauditory brain structures of hamsters previously exposed to intense sound. Exp Brain Res. 153: 655-60.

44. Zhang, J.S., Kaltenbach, J.A., Wang, J. and Bronchti, G. (2003) Changes in [14C]-2-deoxyglucose uptake in the auditory pathway of hamsters previously exposed to intense sound. Hear Res. 185:13-21.

45. Kaltenbach, J.A. (2003) Breakthrough in Hair Cell Regeneration. Tinnitus Today  28, 12-13.

46. Kaltenbach, J.A. (2004) Where in the brain is tinnitus? Tinnitus Today, 29, 5-6.

47. Kaltenbach, J.A., Kaltenbach, J.A., Zacharek, M.A. Zhang, J-S. and Frederick, S. (2004) Activity in the dorsal cochlear nucleus of hamsters previously tested for tinnitus following intense tone exposure. Neuroscience Lett. 355(1-2):121-5.

48. Kaltenbach, J.A., Zhang, J-S. (2004) In Vivo Optical imaging of tone-evoked activity in the dorsal cochlear nucleus with a voltage sensitive dye. J. Neurosci. Res. 78, 908-917.

49. Kaltenbach, J.A., Zhang, J.S. (2005) Tinnitus as a plastic phenomenon and its possible neural underpinnings in the dorsal cochlear nucleus. Invited paper for Special Issue of Hear. Res. Hear. Res. 206, 200-226.

50. Finlayson, P. and Kaltenbach, J.A. (2006) Classification of spike waveforms of single units in the hamster dorsal cochlear nucleus. Brain Res. 1069, 63-74.

51. Kaltenbach, J.A. (2006) The dorsal cochlear nucleus as a participant in the auditory, attentional and emotional aspects of tinnitus. Hearing Res. (Invited paper for Special Issue of Hearing Res., 216-217, 224-234.

52.  Jin, YM., Godfrey, D.A., Wang, J., Kaltenbach, J.A.  (2006) Effects of Intense Tone Exposure on Choline Acetyltransferase Activity in the Hamster Cochlear Nucleus. Hearing Res. 216-217, 168-175.

53. Zhang, J-S., Kaltenbach, J.A., Godfrey, D.A., Wang, J., (2006) Origin of hyperactivity in the hamster dorsal cochlear nucleus following intense sound exposure. J. Neurosci. Res. 84, 819-831

54. Kaltenbach, J.A. (2006) Summary of evidence pointing to a role of the dorsal cochlear nucleus in the etiology of tinnitus. Acta Otolaryngologica. Invited paper for special issue of Acta Otolaryngologica, 126, 20-26.

55. Kaltenbach, J.A. (2006) Roadmap to a Cure. Cover article, Tinnitus Today, 31, 6-7.

56. Kaltenbach, J.A. (2007) The dorsal cochlear nucleus as a contributor to tinnitus: Mechanisms underlying noise-induced hyperactivity.  Progr. Brain Res. 166: 89-106.

57. Kaltenbach, J.A. and Zhang, J-S., (2007) Intense sound-induced plasticity in the dorsal cochlear nucleus of rats: Evidence for cholinergic receptor upregulation. Hearing Res. (Invited paper for Special Issue of Hearing Res. 226: 232-243.

58. Whitmore, F. C.  and Kaltenbach, J.A.. (2008). Neogene Cetacea of the Lee Creek Phosphate Mine, North Carolina. Virginia Museum of Natural History Special Publication 14:181-269.

59. Godfrey, D.A. Mikesell, N. L, Godfrey, T.G. Fulcomer, A. B,. Kong, W., Godfrey, M.A., Kaltenbach, J.A., Zhang, J. (2008) Effects of high-intensity sound exposure on neurotransmitter chemistry in the central auditory system. Seminars in Hearing 29: 259-269.

60. Kaltenbach, J.A. and Godfrey, D.A. (2008) Dorsal cochlear nucleus hyperactivity and tinnitus: Are they related? American Journal of Audiology, Am J Audiol. 17: S148-61.

61. Kaltenbach, J.A. (2009) Insights on the origins of tinnitus: An overview of recent research. Hearing Journal, 62, 26-29.

62. Finlayson, P. and Kaltenbach, J.A. (2009) Alterations in the spontaneous discharge patterns of single units in the Dorsal Cochlear Nucleus following Intense Sound Exposure. Hearing Res. (In Press).

Education & Fellowships

Fellowship - University of Pennsylvania
Neurophysiology
Philadelphia, PA USA
1987
Doctorate - University of Pennsylvania
Biology
Philadelphia, PA USA
1984
Graduate - Towson State University
Biology
Towson, MD USA
1980
Undergraduate - George Washington University
Geology
Washington, DC USA
1975

Additional Training

There are several studies under way or in the planning phase in different subspecialties in the Head & Neck Institute. Our full-time, dedicated researcher, James Kaltenbach, PhD, is interested in the elucidation of underlying neuronal mechanisms, the identification of new treatment targets and experimentation with novel approaches that will lead to improvement in clinical therapy of tinnitus. Visit the Laboratory of Neurotology in the Lerner Research Institute for more information.

Treatment & Services

  • General ENT

Industry Relationships

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As of 2/13/2014, Dr. Kaltenbach has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by the Cleveland Clinic. To learn more about the Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers’ discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Languages Spoken

  • English
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