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Andre Machado, MD, PhD

216.636.5860

Andre Machado, MD, PhD
Department: Neurological Institute
Institute Chair
Location: Cleveland Clinic Main Campus
Mail Code S31
9500 Euclid Avenue
Cleveland, OH 44195
WorkAppointment:216.636.5860
WorkFax:216.444.1015
Andre Machado, MD, PhD
Department: Center for Neuro-Restoration
Director
Location: Cleveland Clinic Main Campus
Mail Code S31
9500 Euclid Avenue
Cleveland, OH 44195
WorkAppointment:216.636.5860
WorkFax:216.444.1015
Andre Machado, MD, PhD
Department: Neurological Surgery
Location: Cleveland Clinic Main Campus
Mail Code S31
9500 Euclid Avenue
Cleveland, OH 44195
WorkAppointment:216.636.5860
WorkFax:216.444.1015
Andre Machado, MD, PhD
Department: Neurosciences
Location: Cleveland Clinic Main Campus
Mail Code S31
9500 Euclid Avenue
Cleveland, OH 44195
WorkAppointment:216.636.5860
WorkFax:216.444.1015
Andre Machado, MD, PhD
Department: Biomedical Engineering
Location: Cleveland Clinic Main Campus
Mail Code S31
9500 Euclid Avenue
Cleveland, OH 44195
WorkAppointment:216.636.5860
WorkFax:216.444.1015
Andre Machado, MD, PhD
Department: Gamma Knife Center
Location: Cleveland Clinic Main Campus
Mail Code S31
9500 Euclid Avenue
Cleveland, OH 44195
WorkAppointment:216.636.5860
WorkFax:216.444.1015
Surgeon:
Yes
Type of Doctor:
Adults Only

Biographical Sketch

Andre Machado, M.D., Ph.D. Director, Center for Neurological Restoration, Neurological Institute

Dr. Machado is the Director of the Center for Neurological Restoration at the Cleveland Clinic Neurological Institute and the Charles and Christine Carroll Endowed Chair in Functional Neurosurgery. The Center for Neurological Restoration houses all clinical activities related to movement disorders, chronic pain and headaches at Cleveland Clinic Neurological Institute as well as functional and stereotactic neurosurgery, deep brain stimulation and other forms of neuromodulation. Dr. Machado performs deep brain stimulation (DBS) surgery for patients with Parkinson’s disease, tremor, dystonia and obsessive-compulsive disorder as well as surgical procedures for patients with trigeminal neuralgia, intractable pain syndromes and spasticity.

Dr. Andre Machado received his medical degree from the University of Sao Paulo in 1997. He completed his residency in the same institution in 2003 and obtained his Ph.D. in 2004. He came to the Cleveland Clinic in 2004, completed his fellowship in Stereotactic and Functional Neurosurgery in 2006 and has been on the staff of the Cleveland Clinic since then.

Dr. Machado is the program director for education in Stereotactic and Functional Neurosurgery and won the “Teacher of the year award” from the Department of Neurosurgery in 2009. Dr. Machado is Full Staff in the Department of Neurosurgery with Joint Appointments in the Department of Neuroscience and in the Department of Biomedical Engineering at the Cleveland Clinic Lerner Research Institute. He is the current Chairman for the Joint Pain Section of the CNS/AANS and he is a Board Member of the American Society of Stereotactic and Functional Neurosurgery.

Dr. Machado leads several deep brain stimulation and neuromodulation clinical trials as well as laboratory research. His research in deep brain stimulation for thalamic pain syndrome was awarded the National Institutes of Health Director’s New Innovator’s Award. In addition, he conducts deep brain stimulation research for treatment refractory depression as well as obsessive compulsive disorder. His laboratory in the Lerner Research Institute is focused in developing new strategies for utilizing neuroprosthetic devices such as DBS to improve post-stroke rehabilitation. His current NIH funded research is aimed at evaluating the effects of deep cerebellar stimulation on post-stroke perilesional plasticity and recovery of function.

Dr. Machado is the author of several peer reviewed publications and chapters in stereotactic and functional neurosurgery.

Education & Fellowships

Fellowship - Cleveland Clinic
Functional Neurosurgery
Cleveland, OH USA
2006
Graduate - University of Sao Paulo Faculty of Medicine
Sao Paulo Brazil
2004
Residency - University of Sao Paulo Hospitals and Clinics
Neurosurgery
Sao Paulo Brazil
2004
Internship - Universidade de Sao Paulo
Sao Paulo Brazil
1998
Medical School - University of Sao Paulo Faculty of Medicine
Sao Paulo Brazil
1997

Certifications

  • Brazilian Society of Neurosurgeons- Neurological Surgery

Specialty Interests

Stereotactic and functional neurosurgery, surgery for Parkinson's Disease, movement disorders and deep brain stimulation, surgical management of chronic pain, conditions including spinal cord stimulation, deep brain stimulation for pain, psychiatric disorders and emerging applications

Awards & Honors

  • Gildenberg Award in Stereotactic and Functional Neurosurgery

Innovations & Patents

  • Preclinical research on deep-brain stimulation for rehabilitation of motor function following strokes
  • First randomized clinical trial of deep brain stimulation for thalmic pain syndrome
  • Research in new devices for deep brain stimulation
  • Research in new devices for neuromodulation, invasive and non-invasive
  • Emerging applications of deep brain stimulation including psychiatric disorders and traumatic brain injury
  1. Intraluminal electrode assembly. US 7,532,938
  2. Methods of treating medical conditions by neuromodulation of the cerebellar pathways. US 7,640,063
  3. Methods of treating neurological conditions by neuromodulation of interhemispheric fibers. US 7,697,991
  4. Corpus Callosum Neuromodulation Assembly. US 7,725,196
  5. Method and system for treating acute heart failure by neuromodulation. US 8,818,501
  6. Methods and systems of achieving hemodynamic control through neuromodulation. 20060100667
  7. Systems and methods for neuromodulation using pre-recorded waveforms. 20080208284
  8. Methods and apparatus for securing a neuromodulation lead to nervous system tissue or tissue surrounding the nervous system. 2009007644
  9. Corpus Callosum Neuromodulation Method. US 8.942,812

Memberships

  • American Society for Stereotactic and Functional Neurosurgery
  • Pain Executive Committee of the Congress of Neurological Surgeons
  • International Association for the Study of Pain
  • North American Neuromodulation Society

Treatment & Services

Specialty in Diseases and Conditions

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 9/16/2015, Dr. Machado has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Machado receives fees of $5,000 or more per year as a paid consultant, speaker or member of an advisory committee for the following companies:

  • Functional Neuromodulation Ltd.
  • Spinal Modulation, Inc.
  • St. Jude Medical, Inc.

Right to Future Distribution of Cleveland Clinic Financial Interest. Dr. Machado may receive future financial benefits from the Cleveland Clinic for inventions or discoveries commercialized through the companies shown below:

  • Autonomic Technologies, Inc.
  • CardioNomic
  • Enspire DBS

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers’ discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Languages Spoken

  • English
  • Portuguese

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