Bin Yang, MD, PhD

216.445.0306

Bin Yang, MD, PhD

Appointed: 2003

Bin Yang, MD, PhD
Department: Anatomic Pathology
Location: Cleveland Clinic Main Campus
Mail Code L25
9500 Euclid Avenue
Cleveland, OH 44195
WorkAppointment:216.445.0306
WorkFax:216.445.6967
Bin Yang, MD, PhD
Department: Cancer Biology
Location: Cleveland Clinic Main Campus
Mail Code L25
9500 Euclid Avenue
Cleveland, OH 44195
WorkAppointment:216.445.0306
WorkFax:216.445.6967
Bin Yang, MD, PhD
Department: Obstetrics and Gynecology
Location: Cleveland Clinic Main Campus
Mail Code L25
9500 Euclid Avenue
Cleveland, OH 44195
WorkAppointment:216.445.0306
WorkFax:216.445.6967
Surgeon:
No
Treats:
Adults Only

Biographical Sketch

Bin Yang, MD, PhD, is a Staff in the Pathology and Laboratory Medicine Institute of the Cleveland Clinic. He is the Medical Director of Molecular Cytopathology and Director of Cancer Epigenetics Core Laboratory in the Department of Anatomic Pathology. Dr. Yang is clinically specialized in gynecologic pathology and diagnostic cytopathology including fine needle aspiration service.

Dr. Yang is also an expertise in molecular pathology with focus on translation of advanced molecular techniques into disease detection and prognostic monitoring. His research interests are in two areas: 1) Application of advanced molecular techniques for early detection of cancer cells in cytologic materials, such as PAP smears and urine; and  2) Application of advanced molecular techniques in prediction of chemosensitivity in gynecologic cancers such as ovarian cancer. From technical point of view, analyzing the methylation profiling of tumor suppressor genes is the primary focus of his research.

Dr. Yang's study on DNA methylation profiling of a set of tumor suppressor genes has achieved prominent progress by identifying some interesting biomarkers differentially methylated in different dysplastic stages of cervical cancer. Their study has been recognized recently as the annual meeting of the American Society of Cytopathology in Houston and has been awarded "The Geno Saccomanno New Frontiers of Cytology Award" in November 2007. He is the only recipient who was awarded twice for this prestigious award.

He was the President of the Chinese American Pathologist Association, a professional organization which has 300+ pathologists with Chinese ethnic background. Currently he is the consultant pathologist for the Preventive Oncology International and consultant in Sino-US Cervical Cancer Programs of under-served areas in China. Dr. Yang has given numerous speeches and presentations as invited speaker at the national and international conferences.

Bin Yang received his M.D. in Zhengzhou University School of Medicine in China in 1983, his Ph.D. training in Molecular Biology under supervision of Dr. Sanford Markowitz, an investigator at the Howard Houghes Medical Institutions at the Case Western Reserve University in 1996. He finished his pathology residency training in 2000 at the Cleveland Clinic, his surgical pathology fellowship training in 2001 at the Washington University in St. Louis, and his cytopathology fellowship and molecular pathology training in 2003 at the Johns Hopkins Medical Institutions in Baltimore.

Professional Highlights

  • President of the Chinese American Pathologist Association (CAPA) 2007-2008
  • President-elect of the Chinese American Pathologist Association  2006-2007

Education & Fellowships

Fellowship - Johns Hopkins Hospital
Cytopathology
Baltimore, MD USA
2003
Fellowship - Barnes-Jewish Hospital/Washington University School of Medicine
Surgical Pathology
St. Louis, MO USA
2001
Residency - Cleveland Clinic
Pathology
Cleveland, OH USA
2000
Doctorate - Case Western Reserve University
Molecular Biology
Cleveland, OH USA
1996
Medical School - Zhengzhou University School of Medicine
Henan China
1983

Certifications

  • Anatomic Pathology
  • Anatomic Pathology- Cytopathology

Specialty Interests

Cytopathology, Gynecologic pathology, fine needle aspiration, Molecular Pathology

Awards & Honors

  • Patient Advocacy Award for promoting Pap tests and cervical cancer screening in under-served rural areas in China, from American Society of Cytopathology 2008
  • ASC Research Seed Award from American Society of Cytopathology 2008
  • Outstanding Achievement Award from Chinese American Pathologist Association 2008
  • Geno Saccomanno New Frontiers in Cytology Award, from American Society of Cytopathology 2007 (only person who has received this prestigious award twice)
  • Innovator Award for innovation in molecular cytopathology from Cleveland Clinic Foundation, 2006
  • Hans Popper Research Award from American Society of Hepatopathology, 2003
  • Young Investigator Award for excellence in Clinical Research from Johns Hopkins Medical Institutions, 2003
  • Geno Saccomanno New Frontiers in Cytology Award from American Society of Cytopathology, 2002
  • George Hoffman Award for excellent resident from Cleveland Clinic Foundation, Department of Pathology, 2000
  • Resident Research Awards (First and Second Places) from Cleveland Society of Pathologists, 1999
  • William E. Lower Clinical Research Award (Honorable Mention) from Cleveland Clinic Foundation, 1999

Innovations & Patents

We have successfully filed a US patent with a title of "Detection of urothelial carcinoma in urine using DNA methylation profiling of tumor suppressor genes." (US utility patent #05136). Our study showed that using DNA methylation profiling, the sensitivity in detection of low grade bladder urothelial carcinoma is increased from 20% by cytomorphology alone to 85% using molecular approaches.

Memberships

  • United States and Canadian Academy of Pathology
  • College of American Pathologists
  • American Society of Investigative Pathology
  • American Association of Cancer Research
  • American Society of Cytopathology

Treatment & Services

  • Cytopathology
  • Gynecologic Surgical Pathology Slide Review
  • Molecular Pathology

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. The Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, the Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 6/9/2014, Dr. Yang has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by the Cleveland Clinic. To learn more about the Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers’ discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Languages Spoken

  • Chinese
  • English
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