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Ajay Gupta, MD


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Ajay Gupta, MD
Department: Epilepsy Center
Section Head, Pediatric Epilepsy
Location: Cleveland Clinic Main Campus
Mail Code S51
9500 Euclid Avenue
Cleveland, OH 44195
Type of Doctor:
Children & Adolescents Only

Biographical Sketch

Ajay Gupta, M.D. is the head of the section of Pediatric Epilepsy in the Epilepsy Center/Neurological Institute. He is Associate Professor at The Cleveland Clinic Lerner College of Medicine, Case Western Reserve University. He is also the founder director of multidisciplinary Tuberous Sclerosis Program at the Cleveland Clinic.


Dr. Gupta is an expert in the field of childhood and adolescent epilepsy with emphasis on epilepsy surgery evaluation, difficult to treat epilepsy, and management of epilepsy in the setting of cortical dysplasias and neurocutaneous disorders such as Tuberous Sclerosis Complex and Sturge-Weber syndrome.  Dr. Gupta is also a skilled specialist in intra-operative neurophysiological techniques used during brain surgery to map regions of brain for critical function (motor, speech control etc.) as well as malfunction (seizure origin, brain tumors etc.). His expertise attracts national and international consultations from families and practicing Neurologists who seek a second opinion. Dr. Gupta is recognized in the Consumers' Research Council's 'Top Physicians' of America", and Marquis "Who's Who in America".


Dr. Gupta is an accomplished physician, clinical researcher and educator whose talents are tapped by a variety of organizations. He serves on the Pediatric Program Committee, and has served on the Scientific Program Committee of the American Epilepsy Society. He serves on the editorial board of two prestigious international journals in the field, ‘Epileptic disorders’ and ‘Pediatric Neurology’. The International League Against Epilepsy (ILAE), world’s top organization on Epilepsy care, appointed him to the task force that is charged with developing novel diagnostic methods for cortical dysplasia, the most common cause of refractory epilepsy in children. Dr. Gupta also works on the Professional and Scientific Board of the U.S. Tuberous Sclerosis Alliance. He serves on the peer-review panel of national and international journals including Annals of Neurology, Brain and Development, Epilepsia, Epilepsy and Behavior, and European Journal of Pediatric Neurology. He is a fellow member of the American Academy of Neurology, American Epilepsy Society, Child Neurology Society, International Child Neurology Association, and American Academy of Pediatrics. He is also a member of the international affairs committee of the US Child Neurology Society.


Dr. Gupta has made innovative and pioneering contributions to advance the field of epilepsy surgery and treatment of epilepsy in children. He has authored more than 75 original research articles and review papers in the peer-reviewed international journals and textbooks. He mentors resident and fellow trainees from US and abroad during their Neurology and Epilepsy fellowships, and some of them have received highly competitive Junior Investigator Research Awards at the American Epilepsy Society annual meetings. As an advocate of medical education and training, Dr. Gupta has chaired, directed and served as faculty in Epilepsy/EEG courses, workshops, and seminars at the national and international conferences. He also serves as a volunteer faculty for the International League against Epilepsy (ILAE) for epilepsy training of professionals in the developing countries.


After graduating from the University of Punjab, India, Dr. Gupta completed residency and fellowship training in Neurology, Child Neurology, and EEG/Neurophysiology at The Cleveland Clinic Foundation. He also did a clinical research fellowship in Medical Genetics at The St. George’s Hospital Medical School, London, United Kingdom. Dr. Gupta is board certified in Pediatrics, Neurology and EEG/Clinical Neurophysiology.

Professional Highlights

  • Member, Pediatric Program Committee, American Epilepsy Society
  • Member, Special Task Force, diagnostic methods for cortical dysplasia, International League Against Epilepsy (ILAE)
  • Editorial Board, Epileptic Disorders, leading journal from France (John Libbey Eurotext)
  • Member, Scientific Program Committee, American Epilepsy Society
  • Editorial Board, Pediatric Neurology, a leading peer-reviewed journal from US (Elsevier)
  • Professional and Scientific Board, U.S. Tuberous Sclerosis Alliance
  • Member, International Affairs Committee, US Child Neurology Society
  • Professional Advisory Board, Epilepsy Association
    Faculty, International League Against Epilepsy (ILAE), for international educational initiatives in distance learning
  • Co-Editor of book, The Treatment of Epilepsy -- Principles and Practice

Education & Fellowships

Fellowship - Cleveland Clinic
Neurophysiology, Clinical & Ep
Cleveland, OH USA
Residency - Cleveland Clinic
Child Neurology
Cleveland, OH USA
Residency - Cleveland Clinic
Cleveland, OH USA
Fellowship - Saint George's Hospital Medical School, University of London
Clinical Genetics
London United Kingdom
Medical School - Post Graduate Institute of Medical Education and Research
Chandigarh India
Medical School - Punjab University Faculty of Medicine
Punjab India
Medical School - Guru Nanak Dev University Faculty of Medicine
Punjab India
Undergraduate - Punjab University/DAV College
Chandigarh India


  • Neurology with Special Qualifications in Child Neurology
  • Neurology- Clinical Neurophysiology
  • Neurology- Epilepsy

Specialty Interests

Surgical and medical treatment of children with epilepsy, epilepsy treatment in neurocutaneous disorders like tuberous sclerosis complex and sturge weber syndrome, intra-operative monitoring and brain mapping for epilepsy surgery

Awards & Honors

  • Junior Investigator Award to mentored research project on "Outcome after Hemispherectomy in Children", American Epilepsy Society 2011
  • 'America's Top Physicians' list 2010, Consumers' Research Council of America, Washington, DC
  • Junior Investigator Award to mentored research project on Tuberous Sclerosis Complex, American Epilepsy Society 2010
  • Marquis "Who's Who in America" list, 2009
  • Fellow, American Academy of Pediatrics, 2006
  • Outstanding mentored research award to Junior Member, Child Neurology Society, 2006
  • Kiffin Penry Pediatric Epilepsy Fellowship Award, 2001-2002


  • American Epilepsy Society
  • American Academy of Neurology
  • Child Neurology Society (USA)
  • American Academy of Pediatrics
  • International Child Neurology Association

Treatment & Services

  • Center for Pediatric Epilepsy
  • Cortical Brain Mapping
  • Early Epilepsy Surgery
  • Epilepsy Pharmacotherapy with Call Office
  • Epilepsy Surgery
  • Epilepsy Surgery And Video Eeg Evaluation
  • Epilepsy Surgery Evaluation
  • Epilepsy Surgery in Adolescents
  • Epilepsy Surgery In Children
  • Intraoperative Brain Mapping And Monitoring
  • Magnetoencephalography (meg)
  • Neuroimaging (mri, Pet, Spect, Meg Scans)
  • Pediatric Neuroscience
  • Specialized EEG With Subdural Grids
  • Surgery In Brain Malformations
  • Vagal Nerve Stimulation
  • Video EEG Monitoring

Specialty in Diseases and Conditions

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical education about recent trends. The collaborations are reviewed as part of Cleveland Clinic's procedures. Cleveland Clinic publicly discloses payments to its physicians and scientists for speaking and consulting of $5,000 or more per year, and any equity, royalties, and fiduciary relationships in companies with which they collaborate. Cleveland Clinic requires its doctors to approve the public disclosures of their scientific collaborations with industry. As of 5/28/2016 the review process regarding Dr. Gupta's disclosure had not been completed. Patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers’ discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

Languages Spoken

  • English
  • Hindi