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Nizar Zein, MD


Nizar Zein, MD
Department: Gastroenterology and Hepatology
Location: Cleveland Clinic Main Campus
Mail Code A51
9500 Euclid Avenue
Cleveland, OH 44195
Nizar Zein, MD
Department: Transplantation Center
Location: Cleveland Clinic Main Campus
Mail Code A51
9500 Euclid Avenue
Cleveland, OH 44195
Adults Only

Professional Highlights

  • Mikati Foundation Endowed Chair in Liver Diseases and Transplantation

Education & Fellowships

Fellowship - Mayo Clinic
Adult & Pediatric Gastroentero
Rochester, MN USA
Residency - Medical College of Ohio Hospitals
Internal Medicine/Pediatrics
Toledo, OH USA
Internship - Medical College of Ohio Hospitals
Internal Medicine/Pediatrics
Toledo, OH USA
Other - MetroHealth Medical Center
Cleveland, OH USA
Medical School - Tishreen University Faculty of Medicine
Lattakia, Syria Syria

Specialty Interests

Liver disease, liver transplantation, cirrhosis, hepatitis B, hepatitis C, nonalcoholic fatty liver disease, portal hypertension, Wilson's disease, hemochromatosis, autoimmune hepatitis, cholangitis, Budd Chiari, diagnostic and therapeutic EGD (upper endoscopy) and colonoscopy. Medical school education.

Awards & Honors

  • Medical College of Ohio most outstanding resident award 1992
  • Mayo Clinic J Arnold Bargen Award for outstanding achievement in Gastroenterology training 1996
  • American Liver Foundation Scholar Award 1997
  • Innovator Award, Cleveland Clinic 2004
  • Physician of the Year, Cleveland Clinic International Center 2005
  • Innovator Award, cleveland Clinic 2006
  • Academic Achievement Award, Syrian American Medical Society 2007
  • Mikati Foundation Endowed Chair in Liver Diseases and Transplantation 2007
  • Top Doctors in Cleveland, Cleveland Magazine 2007
  • Teacher of the year, Cleveland Clinic 2008

Additional Training

  • Mayo Clinic Scholar 1996-1997

Innovations & Patents

  • NS5 and Core proteins in inducing protective antibodies, MMV # 99-073
  • Inhaled liposomal IL-2 in the treatment of chronic HCV infection, MMV # 01-022
  • Etanercept as an adjuvant to interferon and ribavirin for patients with chronic hepatitis C infection, MMV # 03-07
  • A novel assay using ascetic fluid Lactoferrin to diagnose spontaneous bacterial peritonitis and other bacterial infections in patients with liver cirrhosis (CCF, 2004)
  • Non-invasive diagnostic test (serum cytokeratin-18) for patients with suspected nonalcoholic fatty liver disease (serial # 60/801,728)


  • American College of Gastroenterology
  • American Gastroenterology Association
  • American Association for the Study of Liver Diseases
  • Syrian-American Medical Society

Treatment & Services

Specialty in Diseases and Conditions

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. The Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, the Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 11/20/2014, Dr. Zein has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by the Cleveland Clinic. To learn more about the Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers’ discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Languages Spoken

  • Arabic
  • English