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Clinical Trials

Find epilepsy clinical trials taking place at Cleveland Clinic as well as questions to ask before participating.

Here are some questions to ask your doctor to help you decide if you want to take part in a research study:

  • What is the study trying to find out and how long will it last?
  • What kinds of tests and exams will I have to take while I'm in the study? How much time do these take? What is involved in each test?
  • How often does the study require me to go to the doctor or clinic?
  • Will I be hospitalized? If so, how often and for how long?
  • What are the costs to me? Will my health insurance pay for it?
  • What follow-up will there be? What will happen at the end of the study?
  • What are my other treatment choices? How do they compare with the treatment being studied?
  • What side effects can I expect from the treatment being tested? How do they compare with side effects of standard treatment?

Below, find clinical trials that are currently recruiting:

Currently Recruiting

I. The Spectrum of Familial Epilepsy

This study is a data collection, non-treatment study to locate and study the genes that cause epilepsy.

Eligible subjects will have a diagnosis of epilepsy and a positive family history of epilepsy.

Identified subjects will have one single blood sample and questionnaires to complete.

If you would like more information on this study please contact:

Jocelyn Bautista, MD, Adult Epilepsy, or
Cindy Rose, Clinical Research Coordinator
216.444.7485

II. Cleveland Clinic's Epilepsy Genetics Registry

The purpose of this registry is to serve as a confidential database of medical and genetic information, family history and banked blood samples from persons with epilepsy.

Eligible subjects will have a diagnosis of epilepsy and a positive family history of epilepsy. Control subjects without a history of epilepsy will also be recruited.

Identified subjects and family members will have one single blood sample and questionnaires to complete.

If you would like more information on this study please contact:

Jocelyn Bautista, MD, Adult Epilepsy, or
Cindy Rose, Clinical Research Coordinator
216.444.7485

III. Searching for "Sleep Friendly" Therapies for a sleep population: A Double-Blind, Placebo-Controlled randomized trial to assess the effects of Lacosamide on sleep and wake in adults with Focal Epilepsy

Sleepiness and fatigue are the most common complaints of people with epilepsy and can have a negative impact on quality of life. Though unproven, these problems are often blamed on anti-seizure medications. Cleveland Clinic investigators are studying the impact of the newest anti-seizure medication Lacosamide (Vimpat®) on sleep and wakefulness in adults with focal (partial onset) seizures.

Focal epilepsy, also called partial epilepsy, is a disorder in which seizures are preceded by an isolated disturbance such as a twitching of a part of the body, a particular sensation or feeling, or some other disturbance in consciousness. The study is open to adults 18 and older with focal seizures.

Participation involves a physical exam, sleep testing at the Sleep Center, blood tests, completion of study questionnaires/diaries, and a random assignment to either take the study drug or placebo (often called a “look alike” or “sugar pill”) for 5 to 8 weeks. There are 5 study visits and participants will receive compensation for time spent in the study.

If you would like more information on this study please contact:

Nancy Foldvary-Schaefer, DO, Cleveland Clinic Sleep Disorders Center at 216.445.2990, or
Monica Bruton, Study Coordinator at 216.444.6718