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Research & Scholarship

In addition to outstanding clinical training, the Critical Care fellowship at Cleveland Clinic is designed to expose fellows to the scientific underpinnings of clinical practice and to familiarize them with research methodology and biostatistics. All fellows are expected to engage in a research project in conjunction with a faculty mentor. Our institute employs full time, embedded biostatisticians as a resource to fellows doing research. Research opportunities are broad and include both clinical and laboratory-based topics ranging from ARDS to critical care resource utilization, critical care ultrasound, ICU quality improvement or ventilator management. Our institute enjoys access to large institutional databases that interested fellows may leverage as part of their research. Fellows are expected to present their research at one of the annual professional society meetings and are encouraged to prepare a manuscript for submission to a scientific or clinical journal.

A structured mentoring process is essential to ensuring the success of research training during fellowship. All fellows meet with the program directors and department chair on a twice-yearly (as well as an ad hoc) basis to discuss their clinical, research, and career interests. One goal of these meetings is to direct the fellow to specific faculty members to serve as a research and career mentor. Together, the fellow and mentor will outline career objectives, a research topic, and necessary education or clinical experiences to meet those goals. It is expected that the faculty member and fellow will work together throughout the remainder of fellowship to ensure progress as well as to provide ongoing research and career support.

2nd Year Biostatistics Course

A ten-month lecture series is provided to the fellows focusing on a detailed introduction to the theory and application of statistical techniques that are commonly used in clinical research. Topics include: probability distribution, graphical presentation of data, frequency distributions, measures of central tendency and dispersion, one-sample and two-sample inference (hypothesis testing), interval estimation (confidence intervals), sample size and power calculations, measures of association, t-tests, non-parametric analysis, and analysis of variance, chi-square test, applications of sample size and statistical power, correlation and linear regression, survival analysis and Cox multivariate regression. This course seeks to fulfill the need to better understand medical statistics as it pertains to practicing evidence based medicine, communicating treatment outcome probability to patients and interpreting the results of studies and scientific papers, and in turn improving quality of patient care.

Embedded Biostatistician

We have two biostatisticians within the Respiratory Institute who play a crucial role in ongoing research studies conducted by our fellows and faculty, starting from the phase of shaping the idea of the project to the completion of the abstract or manuscript. Fellows are also welcome and encouraged to contact the biostatisticians to discuss and critique articles assigned to them for journal club.

Department of Quantitative Health Sciences Courses

The Department of Quantitative Health Sciences of the Lerner Research Institute offers a series of courses available to fellows seeking more in-depth learning in the areas of medical biostatistics, clinical epidemiology, clinical trials design and operation. Further details are provided on the QHS website.

Case Western Masters Program

Case Western Reserve offers a Masters of Science in Clinical Research.

This two year program is designed to provide physicians with rigorous didactic education in clinical research methods coupled with an in-depth mentored investigative experience.

Acceptance to this program is competitive and a demonstrated commitment to research and a career in academics is essential. Within our fellowship program, opportunity to apply, and full tuition support if accepted, would be offered to a maximum of one fellow per year who has selected the specialized research pathway as his/her advanced training pathway.

Involvement in this program would require extension of fellowship training.

Faculty in the Respiratory Institute serve as investigators for a wide array of NIH- and industry-sponsored research projects and clinical trials. In turn, this provides our fellows with a wealth of research opportunities encompassing the full spectrum of laboratory-based, translational, and clinical projects.

Current clinical trials.